Evaluating the use of early hormonal therapy in patients with localised or locally advanced prostate cancer

Kaisary, Amir V.

doi:10.1038/sj.pcan.4500800

Cited by 11 publications

(9 citation statements)

References 60 publications

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“…18 Additionally, ADT is now used as adjuvant therapy to radical prostatectomy and radiotherapy. 16 Although very effective, 16 concerns related to the detrimental effects of ADT on muscle, fat and bone mass have arisen as it can exacerbate the risk of sarcopenia, osteoporosis and obesity, and therefore induce other health related complications. This array of side effects related to ADT affecting the musculoskeletal system and physiological function or 'Androgen Deprivation and Sarcopenia-Related Disorders' is presented in Table 1.…”

Section: Treatment Of Prostate Cancermentioning

confidence: 99%

“…ADT is a widely employed means of treating this cancer, and is achieved by either surgical castration or more commonly by administering LHRHa (luteinizing hormone-releasing hormone agonist) and/or antiandrogen medications that block the androgen receptors. 16 Traditionally, ADT has been administrated in the latter stage of prostate cancer (for example presence of metastases). 17 However, owing to earlier detection of prostate cancer through better screening (for example PSA), patients are undertaking ADT in the early stages of the disease and therefore being exposed to this therapy for longer periods of time.…”

Section: Treatment Of Prostate Cancermentioning

confidence: 99%

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Exercise can prevent and even reverse adverse effects of androgen suppression treatment in men with prostate cancer

Galvão

Taaffe

Spry

et al. 2007

Prostate Cancer Prostatic Dis

101

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Side effects accompanying androgen deprivation therapy (ADT), including sarcopenia, loss of bone mass and reduction in muscle strength, can compromise physical function, particularly in older patients. Exercise, specifically resistance training, may be an effective and cost-efficient strategy to limit or even reverse some of these adverse effects during and following therapy. In this review, we discuss common morphological and physiological ADT-related side effects or 'Androgen Deprivation and Sarcopenia-Related Disorders' and the existing clinical trials incorporating physical exercise in prostate cancer patients receiving active therapy. Further, training concepts and guidelines are provided for prescribing resistance exercise programs for this population.

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Section: Treatment Of Prostate Cancermentioning

confidence: 99%

Section: Treatment Of Prostate Cancermentioning

confidence: 99%

Exercise can prevent and even reverse adverse effects of androgen suppression treatment in men with prostate cancer

Galvão

Taaffe

Spry

et al. 2007

Prostate Cancer Prostatic Dis

101

View full text Add to dashboard Cite

show abstract

“…1,2 ADT is achieved by either surgical castration, or more commonly by administering luteinizing hormone-releasing hormone agonist (LHRHa) or antiandrogen medications that block the androgen receptors, or both. 2 However, ADT is accompanied by a range of adverse effects including reduced muscle strength, lean and bone mass, increased fat mass and fracture risk. 3,4 These side effects are clinically important, because they are likely to compromise physical function, reduce independence and quality of life.…”

Section: Introductionmentioning

confidence: 99%

Endocrine and immune responses to resistance training in prostate cancer patients

Galvão

Nosaka

Taaffe

et al. 2007

Prostate Cancer Prostatic Dis

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This study examined the effect of 20 weeks resistance training on a range of serum hormones and inflammatory markers at rest, and following acute bouts of exercise in prostate cancer patients undergoing androgen deprivation. Ten patients exercised twice weekly at high intensity for several upper and lower-body muscle groups. Neither testosterone nor prostate-specific antigen changed at rest or following an acute bout of exercise. However, serum growth hormone (GH), dehydroepiandrosterone (DHEA), interleukin-6, tumor necrosis factor-a and differential blood leukocyte counts increased (Po0.05) following acute exercise. Resistance exercise does not appear to compromise testosterone suppression, and acute elevations in serum GH and DHEA may partly underlie improvements observed in physical function.

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“…Androgen deprivation therapy (ADT), via a gonadotropin releasing hormone (GnRH) agonist, is effective in the treatment of locally advanced prostate cancer. [1][2][3][4] GnRH agonists reduce the serum androgen level and as a result inhibit the growth of prostate cancer cells. The altered androgen level, however, is associated with a number of adverse side effects including reduced lean body mass or muscle mass, reduced bone mineral density, reduced muscle strength, increased fat mass and insulin resistance.…”

Section: Introductionmentioning

confidence: 99%

Effect of androgen deprivation therapy on muscle attenuation in men with prostate cancer

et al. 2013

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Introduction: Aging skeletal muscle is associated with not only a reduction in muscle size and strength but also in muscle quality which reflects an increase in fatty infiltration of muscle. In men with prostate cancer, androgen deprivation therapy (ADT) accelerates this loss of muscle size and strength, but it is unknown if muscle quality is also adversely affected. Therefore, we examined the effects of ADT on muscle attenuation, an indirect measure of intramuscular lipid content, as well as the muscle cross-sectional area (CSA) in men with prostate cancer. Methods: Pre-and post-CT scans of the pelvis in 39 men aged 49-78 years receiving leuprorelin were examined. The time between baseline and follow-up scans was 14.6-20 weeks after the commencement of ADT. Changes in skeletal muscle attenuation in Hounsfield units of the rectus femoris and the CSA of the rectus femoris, sartorius and quadricep muscles were assessed. Results: Muscle attenuation of the rectus femoris muscle was significantly reduced following the initiation of ADT by 18.9% (P < 0.001). In addition, there was a significant decrease (P < 0.001) in the CSA for the sartorius, quadriceps and rectus femoris muscles. There was no effect of Zometa on muscle attenuation or muscle CSA. Conclusions: Our results indicate that not only muscle size but also muscle quality may be adversely affected by the undertaking of ADT in men with prostate cancer. Consequently, interventions to counteract deteriorations to both muscle mass and possibly muscle quality should be considered in men receiving ADT.

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Evaluating the use of early hormonal therapy in patients with localised or locally advanced prostate cancer

Cited by 11 publications

References 60 publications

Exercise can prevent and even reverse adverse effects of androgen suppression treatment in men with prostate cancer

Exercise can prevent and even reverse adverse effects of androgen suppression treatment in men with prostate cancer

Endocrine and immune responses to resistance training in prostate cancer patients

Effect of androgen deprivation therapy on muscle attenuation in men with prostate cancer

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