Power units of thermal power plants (TPP), state-owned district power plants (SDPP), combined heat and power plants (CHPP) are mega-complexes, the maintenance of which requires huge investments and significant natural resources (fossil fuels and water). The operation of the units leads to a permanent negative impact on the environment, in spite of strict standards for emissions and discharges. This article analyzes the impact of power plants on water bodies. The following measurements are given for the runoff of the Novocherkassk SDPP to the Don River (Russia, Rostov Region): temperature, odor, power of hydrogen (pH-value), transparency, suspended materials, dissolved oxygen, biological oxygen demand in 5 days (BOD5), TBOD, chemical oxygen demand (COD), mineralization, chlorides, sulfates, hydrogen carbonates, alkalinity, calcium, magnesium, hardness, sodium + potassium, ammonium ions, nitrites, nitrates, phosphorus phosphates, total ferrum, copper, aluminum, synthetic surface active substances, petroleum products, toxicity. It is established that the indicators are within the permissible values established by regulatory documents (Russia).