Biochemical Pharmacology volume 81, issue 7, P825-837 2011 DOI: 10.1016/j.bcp.2011.01.003 View full text
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Michael Carty, Andrew G. Bowie

Abstract: AbstractA key part of the innate immune system is a network of pattern recognition receptors (PRRs) and their associated intracellular signalling pathways. Toll-like receptors (TLRs) are one such group of PRRs that detect pathogen associated molecular patterns (PAMPs). Activation of the TLRs with their respective agonists results in the activation of intracellular signalling pathways leading to the expression of proinflammatory mediators and anti-microbial effector molecules. Activation of the innate immune s…

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