Evaluating the Association between Hyperuricemia and Contrast InducedAcute Kidney Injury in Patients with Acute ST-Elevation Myocardial Infarction Undergoing Percutaneous Coronary Intervention

Abdallah, Emad; Mosbah, Osama; El-Shistawy, S; Khalifa, Ghada Amin; Badr, Mohamed H.; Aa, Amin

doi:10.36876/smjnt.1003

Cited by 1 publication

(2 citation statements)

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“…19 Likewise, a study by Abdollah et al conducted on 146 patients with acute STEMI underwent primary PCI concluded that 8.8% of the patients experienced developed CIN, 14.1% hyperuricemia and 2.94% with normal uric acid had a significant difference and concluded that elevated uric acid was associated with higher risk of CIN in the STEMI patients with normal serum creatinine after PCI. 25 This conflict can be explained so that that the patients in the present study had generally lower risk. Most of the patients in the present study had good kidney function as 73.5% had GFR>60 mL/min.…”

Section: Discussionmentioning

confidence: 64%

“…Most of the articles in this subject are about acute condition like ST elevation MI (STEMI) or acute coronary syndrome. 5,7,19,[25][26][27] The important point of this study compared to other studies was as which this study examined just elective procedures and excluded all the primary PCI and urgent angiography cases. Meanwhile, the present study had enough time to eliminate the nephrotoxic drugs and give enough prophylaxis hydration to all the patients.…”

Section: Introductionmentioning

confidence: 99%

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Is there any association between contrast-induced nephropathy and serum uric acid levels?

Mirbolouk

Arami

Gholipour

et al. 2021

J Cardiovasc Thorac Res

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Introduction: During the recent years, several studies have investigated that hyperuricemia is associated with greater incidence of contrast induced nephropathy (CIN). Most of them are in acute conditions like primary percutaneous coronary interventions. This study aimed to assess the relationship between high serum uric acid and incidence of acute kidney injury in patients undergoing elective angiography and angioplasty. Methods: This prospective study was conducted on 211 patients who were admitted to hospital for elective coronary angiography or angioplasty. The researchers measured serum creatinine and uric acid on admission and repeated creatinine measurement in 48 hours and seven days after the procedure. According to serum uric acid, the patients were divided into two groups; group 1 with normal uric acid and group 2 with hyperuricemia which was defined as uric acid more than 6 mg/dL in women and 7 mg/dL in men. CIN is defined as an increased creatinine level of more than 0.5 mg/dL or 25% from the baseline in 48 hours after the intervention. Results: In total, 211 patients with mean age of 60.58 years were enrolled in the study. Of these, 87 (41.2%) patients were in the high uric acid group and 124 (58.8%) were in the normal uric acid group. CIN was occurred in 16 patients (7.5%). Seven out of 16 (8.04%) were in the high uric acid and nine (7.2%) were in the normal uric acid group. There were no significant differences between the two groups (P =0.831). Conclusion: The frequency of CIN development was not different in the patients with hyperuricemia.

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Section: Discussionmentioning

confidence: 64%