Planning, Designing and constructing road infrastructure should give priority to the safety and comfort for road users. Ironically, road infrastructure often becomes the cause of traffic accidents. However, such problem can be solved with a profound understanding in the effect of road infrastructure formation elements on the risk of accidents, so that the handling taken can be more efficient. This study aims to (1) review and see the effect of road infrastructure on accidents, (2) provide handling efforts to improve road infrastructure safety. Secondary sources in the form of books and academic journals were reviewed to answer the research objectives above. The results of the study indicated that the elements in road infrastructure formation had significant effect on the risk of traffic accident. Preventing and handling traffic accidents in terms of the road infrastructure can start from planning, designing, constructing, and improving road infrastructure in accordance with prevailing procedures such as Road Safety Audit (RSA) and Road Safety Inspection (RSI). The role of government such as making safety design standard, assuring compliance with these rules, and methods to measure and rate the overall level of safety being achieved is needed in order to improve road safety.