Evaluating effect of salt leaching method on release and swelling rate of metformin nanoparticles loaded-chitosan/polyvinyl alcohol porous composite

Yari, Kasra; Gharati, Gelareh; Akbari, Iman

doi:10.1016/j.ijbiomac.2022.11.323

Cited by 7 publications

(5 citation statements)

References 44 publications

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Section: Resultsmentioning

confidence: 88%

“…Second, in DLS, particles are dispersed in water, while in FESEM, the crystals are analyzed in their dry state. Consequently, in DLS, a swelling effect due to the interaction of particles with water must be considered . Considering these aspects, it became evident that the size measurements obtained through both techniques align consistently.…”

Section: Resultsmentioning

confidence: 98%

“…Consequently, in DLS, a swelling effect due to the interaction of particles with water must be considered. 49 Considering these aspects, it became evident that the size measurements obtained through both techniques align consistently. Importantly, previous reports where CUR was converted to NCs using similar media milling methods demonstrated that the process did not induce changes in the crystallinity of the drug, as per confirmed by powder X-ray diffractometry and differential scanning calorimetry.…”

Section: Proton Nuclear Magnetic Resonance ( 1 H Nmr)mentioning

confidence: 88%

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Folic Acid-Decorated Nanocrystals as Highly Loaded Trojan Horses to Target Cancer Cells

Fuster,

Wang,

Fandiño

et al. 2024

Mol. Pharmaceutics

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The nanocrystal (NC) technology has become one of the most commonly used strategies for the formulation of poorly soluble actives. Given their large specific surface, NCs are mainly used to enhance the oral absorption of poorly soluble actives. Differently from conventional nanoparticles, which require the use of carrier materials and have limited drug loadings, NCs' drug loading approaches 100% since they are formed of the pure drug and surrounded by a thin layer of a stabilizer. In this work, we report the covalent decoration of curcumin NCs with folic acid (FA) using EDC/NHS chemistry and explore the novel systems as highly loaded "Trojan horses" to target cancer cells. The decorated NCs demonstrated a remarkable improvement in curcumin uptake, exhibiting enhanced growth inhibition in cancer cells (HeLa and MCF7) while sparing healthy cells (J774A.1). Cellular uptake studies revealed significantly heightened entry of FA-decorated NCs into cancer cells compared to unmodified NCs while also showing reduced uptake by macrophages, indicating a potential for prolonged circulation in vivo. These findings underline the potential of NC highly loaded nanovectors for drug delivery and, in particular, for cancer therapies, effectively targeting folate receptor-overexpressing cells while evading interception by macrophages, thus preserving their viability and offering a promising avenue for precise and effective treatments.

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Section: Resultsmentioning

confidence: 88%

Section: Resultsmentioning

confidence: 98%

Section: Proton Nuclear Magnetic Resonance ( 1 H Nmr)mentioning

confidence: 88%

See 1 more Smart Citation

Folic Acid-Decorated Nanocrystals as Highly Loaded Trojan Horses to Target Cancer Cells

Fuster,

Wang,

Fandiño

et al. 2024

Mol. Pharmaceutics

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“…The beads successfully protected insulin in acid and released insulin slowly in the small intestine. Metformin nanoparticles, which are antihyperglycemic agents, are incorporated into a chitosan/PVA polymeric composite using the salt leaching technique [ 161 ]. This method creates a porous structure that permits the controlled release of the drug, with the rate of release being determined by the size and distribution of the pores within the composite.…”

Section: Pharmaceutical and Biomedical Applications Of Chitosan-based...mentioning

confidence: 99%

Recent Development of Functional Chitosan-Based Hydrogels for Pharmaceutical and Biomedical Applications

Taokaew

Kaewkong

Kriangkrai

2023

Gels

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Chitosan is a promising naturally derived polysaccharide to be used in hydrogel forms for pharmaceutical and biomedical applications. The multifunctional chitosan-based hydrogels have attractive properties such as the ability to encapsulate, carry, and release the drug, biocompatibility, biodegradability, and non-immunogenicity. In this review, the advanced functions of the chitosan-based hydrogels are summarized, with emphasis on fabrications and resultant properties reported in literature from the recent decade. The recent progress in the applications of drug delivery, tissue engineering, disease treatments, and biosensors are reviewed. Current challenges and future development direction of the chitosan-based hydrogels for pharmaceutical and biomedical applications are prospected.

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“…The beads successfully protected insulin from acid, releasing it gradually in the small intestine [143]. Using the salt leaching method, metformin nanoparticles are blended into a chitosan/PVA polymeric composite [144]. This technique creates a porous structure that enables the medicine to be released under regulated conditions; the release rate is based on the size and distribution of the pores inside the composite.…”

Section: Utilization Of Chitosan-based Products In Drug Deliverymentioning

confidence: 99%

Chitosan-Based Composites: Development and Perspective in Food Preservation and Biomedical Applications

Kumar

Yadav

Pramanik³

et al. 2023

Polymers

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Chitin, which may be the second-most common polymer after cellulose, is the raw material of chitosan. Chitosan has been infused with various plant extracts and subsidiary polymers to improve its biological and physiological properties. Chitosan’s physicochemical properties are enhanced by blending, making them potential candidates that can be utilized in multifunctional areas, including food processing, nutraceuticals, food quality monitoring, food packaging, and storage. Chitosan-based biomaterials are biocompatible, biodegradable, low toxic, mucoadhesive, and regulate chemical release. Therefore, they are used in the biomedical field. The present manuscript highlights the application of chitosan-based composites in the food and biomedical industries.

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Evaluating effect of salt leaching method on release and swelling rate of metformin nanoparticles loaded-chitosan/polyvinyl alcohol porous composite

Cited by 7 publications

References 44 publications

Folic Acid-Decorated Nanocrystals as Highly Loaded Trojan Horses to Target Cancer Cells

Folic Acid-Decorated Nanocrystals as Highly Loaded Trojan Horses to Target Cancer Cells

Recent Development of Functional Chitosan-Based Hydrogels for Pharmaceutical and Biomedical Applications

Chitosan-Based Composites: Development and Perspective in Food Preservation and Biomedical Applications

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