Evaluación de la Actividad Antioxidante de Cnidoscolus chayamansa (Chaya), Euphorbia prostrata (Hierba de la Golondrina) y Jatropha dioica (Sangre de Drago) en Ratas Wistar Inducidas a Hiperglicemia

Valenzuela-Soto, Ramón; Jiménez-Villarreal, Joel; García-Garza, Rubén; Betancourt-Martínez, Nadia Denys; Lozoya-Martínez, Rodrigo; Almaráz-Celis, Daniel; Morán-Martínez, Javier

doi:10.4067/s0717-95022019000100036

Cited by 4 publications

(2 citation statements)

References 13 publications

(13 reference statements)

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“…The bush typically grows to the height of 50 to 150 cm. 22,23 The presence of terpenoids compounds, flavonoids, reducing sugars and alkaloids are possibly responsible for the antioxidant effect observed using model radical scavenger (1, 1-diphenyl-2-picrylhydrazyl, DPPH) for the root extracts of JD The presence of terpenoid compounds, flavonoids, reducing sugars, and alkaloids has been identified by observing their antioxidant activity that counteracts FRs in JD root extract. 24 In our previous work it was determined that the ethanolic extracts (70%) obtained from JD were not toxic.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant Effect of Jatropha dioica Extract on Immunoreactivity of Claudin 2 in the Kidney of Rats with Induced Diabetes

Ramírez-Moreno

García-Garza

Escobar

et al. 2023

Natural Product Communications

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Introduction Diabetes is related to different complications, such as nephropathy. In kidneys, the tight junctions (TJ) regulate the paracellular transport of solutes and water. The claudins are the most significant component in the TJ and are expressed throughout the epithelium and modulated permeability. Objective To evaluate the antioxidant effect of Jatropha dioica (JD) extract and claudin 2 (CLDN 2) in the kidney of rats with induced diabetes. Methods It is an experimental, explanatory, prospective, longitudinal, and analytical study. The effect of hydro-alcoholic extract from JD root on the presence of CLDN 2 in rats with induced diabetes was evaluated. The experiment lasting 21 days, treated 40 rats with and without induced diabetes by an intraperitoneal (IP) injection of alloxan. The study groups were exposed to JD extract at 25, 50, and 100 mg/kg. There was no significant morphological difference in the renal tissue morphology of the treated and control groups. Conclusion These results demonstrate that JD extract at 50 mg/kg ameliorated the tubular damage induced by diabetes, and the mechanism might be related to the CLDN2 expression. Finally, JD could also increase total antioxidant capacity to protect the kidney from oxidative stress.

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Section: Introductionmentioning

confidence: 99%

Antioxidant Effect of Jatropha dioica Extract on Immunoreactivity of Claudin 2 in the Kidney of Rats with Induced Diabetes

Ramírez-Moreno

García-Garza

Escobar

et al. 2023

Natural Product Communications

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“…E. serpens presentó un IC 50 1,46 mg/ml, mayor que la especie E. prostrata informado por Soto-Valenzuela et al[38]. Los resultados obtenidos muestran una inhibición significativa del radical DPPH•, lo que indica la potencial acción reductora de radicales libres de estos extractos.…”

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Actividad antioxidante de cuatros especies vegetales del nordeste argentino

Soro

Valenzuela

Núñez

2021

Rev. Colomb. Cienc. Quím. Farm.

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Objetivos: determinar la composición fitoquímica y evaluar la actividad antioxidante de los extractos hidroalcohólicos de S. haematospermum; P. niruri; P. tenellus; E. serpens. Metodología: la composición fitoquímica se analizó por cromatografía en capa fina y la actividad antioxidante se observó de modo cualitativo por ensayo autográfico. Los fenoles totales se cuantificaron con el método de Folin-Ciocalteu y flavonoides totales con la reacción de complejación de aluminio. Para determinar la actividad antioxidante se utilizaron las técnicas de decoloración del radical libre DPPH• (2,2- difenil-1-picrilhidracilo) y del radical catión ABTS°+ (ácido 2,2´-azino-bis (3-etilbenzotiazolin)-6-sulfónico) y del poder reductor del catión hierro (III). Resultados: el estudio fitoquímico evidenció en todas las especies la presencia de metabolitos bioactivos. El contenido de fenoles totales osciló entre: 627,71 ± 1,45 y 369,8±52,6 mg EAG/g muestra y de flavonoides totales fue de 12,2 ± 0,1 hasta 4,5 ± 0,3 mg Q/g muestra. Las especies S. haematospermum y P. tenellus presentaron mayor contenido de polifenoles. Los ensayos de actividad antioxidante permitieron reconocer que S. haematospermum y P. tenellus tienen capacidad de mayor inhibición de los radicales libres probados y mostraron mayor poder reductor los extractos hidroalcohólicos S. haematospermum y P. niruri.

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Additional compounds and the therapeutic potential of Cnidoscolus chayamansa (McVaugh) against hepatotoxicity induced by antitubercular drugs

Pérez-González

Macías-Rubalcava

Hernández‐Ortega

et al. 2019

Biomedicine & Pharmacotherapy

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Evaluación de la Actividad Antioxidante de Cnidoscolus chayamansa (Chaya), Euphorbia prostrata (Hierba de la Golondrina) y Jatropha dioica (Sangre de Drago) en Ratas Wistar Inducidas a Hiperglicemia

Cited by 4 publications

References 13 publications

Antioxidant Effect of Jatropha dioica Extract on Immunoreactivity of Claudin 2 in the Kidney of Rats with Induced Diabetes

Antioxidant Effect of Jatropha dioica Extract on Immunoreactivity of Claudin 2 in the Kidney of Rats with Induced Diabetes

Actividad antioxidante de cuatros especies vegetales del nordeste argentino

Additional compounds and the therapeutic potential of Cnidoscolus chayamansa (McVaugh) against hepatotoxicity induced by antitubercular drugs

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