Euscorpius (Scorpiones, Euscorpiidae): three cases of stings in northwestern Italy

Dutto, Moreno; Dutto, Lorenzo; Scaglione, N; Bertero, Maria Tiziana

doi:10.1590/s1678-91992010000400018

Cited by 8 publications

(4 citation statements)

References 14 publications

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“…Our findings also corroborate previously reported cases in the literature regarding envenoming characteristics such as locoregional pain that disappears within an hour after the sting (4,5).…”

Section: Discussionsupporting

confidence: 92%

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Stings from Euscorpius flavicaudis (De Geer, 1778) (Scorpiones, Euscorpiidae) during pregnancy: a clinical case report

Dutto¹,

Dutto

Bertero

et al. 2012

J. Venom. Anim. Toxins incl. Trop. Dis

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Abstract:We report a case in which a 21-week pregnant woman was stung by a Euscorpius flavicaudis (De Geer, 1778) scorpion. Symptoms and signs experienced by the patient were the same as those documented in the literature and with no ill-effects for the pregnancy. Envenoming was local and of low degree of intensity. It is important to emphasize that the patient was stung in her home, which differs from stings in most other parts of the world, in which scorpionism is mostly a risk in outdoor areas.

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Section: Discussionsupporting

confidence: 92%

“…Scorpions of the genus Euscorpius, as indicated by the literature, secrete toxins that provoke local and short term (30-90 minutes) reactions in humans (4)(5)(6). Data are scarce with regard to scorpion stings in pregnant women.…”

Section: Introductionmentioning

confidence: 99%

Stings from Euscorpius flavicaudis (De Geer, 1778) (Scorpiones, Euscorpiidae) during pregnancy: a clinical case report

Dutto¹,

Dutto

Bertero

et al. 2012

J. Venom. Anim. Toxins incl. Trop. Dis

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“…This characteristic has been seen in different scorpion venoms[16,17]. This rapid process is due to scorpion toxins and is in accordance with the rapid appearance of sign and symptoms in the stung victims[18,19]. In PO administration, considering T max , the absorption of venom was slow, followed by a slow distribution phase compared to IV route.…”

Section: Discussionmentioning

confidence: 62%

Pharmacokinetics and Biodistribution of Rhopalurus junceus Scorpion Venom in Tumor-Bearing Mice after Intravenous and Oral Administration

Díaz-García¹,

González

Bernabeu

et al. 2019

ibj

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Introduction: Rhopalurus junceus scorpion venom has shown potential for anticancer treatment. However, there are no scientific evidence about venom pharmacokinetic (PK) and biodistribution (BD) in tumor-bearing mice. Methods: 131 I-labeled venom was administrated by intravenous (IV) and oral (PO) routes at the single dose of 12.5 mg/kg. Mice were sacrificed and blood samples, major organs, and tumor were taken at 10, 20, 40, 90, 180, 300, 480, and 1440 min. Results: For IV route, maximum peak concentration (C max ), elimination half-lives, total body clearance (CL), distribution volume (V d ), mean residence time (MRT), and area under curve (AUC) were 21.77 ± 2.45 %Dosis·h/mL, 12.65 ± 2.1 h, 4.59 ± 0.23 mL/h, 83.80 ± 12 mL, 12.49 ± 2.71 h, and 21.77 ± 2.45 %Dosis·h/mL, respectively. For PO route, they were 0.60 ± 0.07 %Dosis·h/mL, 9.33 ± 1.35 h, 36.94 ± 4.01 mL/h, 497.33 ± 30 mL, 12.40 ± 1.87 h, and 6.89 ± 1.18 %Dosis·h/mL, respectively. PK parameters (C max , CL, V d , and AUC) showed significant differences between IV and PO routes. Bioavailability was 31.6 ± 4% for PO dose. Kidney, stomach, liver, and lung for IV and stomach, kidney, spleen, and lung for PO routes showed the major uptakes for 131 Ilabeled venom. In tumor tissue, after the maximum uptake for both routes, there was a consistent behavior of radioactivity respect to the major organs during the first 480 min. Conclusion: The PK and BD of R. junceus venom in mice depend on the administration route. These data represent a starting point for future experiments with this scorpion venom in experimental models of cancer.

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“…Their results suggest that scorpion envenomation may induce some disturbances and threatens both mother's and fetus' well-being. The neurotoxins found in scorpion venom that are harmful to humans affect mainly sodium channels in excitable cells [5].…”

Section: Introductionmentioning

confidence: 99%

Scorpion sting during pregnancy: A case report accompanied by literature

Kamalak¹,

Köşüş²

2013

CMJ

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Envenomation is an unusual event in developed countries. Rural population who lives in arid climate is incur this danger. Scorpion sting is one of the envenomation. It is a major public health problem in many underdeveloped tropical countries. In Turkey, epidemiological studies have shown that most scorpion stings affect females. The highest incidence of scorpion stings was recorded for the warmest months of the year since scorpions become more active in the warm season. Diagnosis is obvious from the history. Also pain, erythema, induration, and wheal may be present at the sting point. In pregnancy envenoming is more dangerous but scorpion envenoming is less studied during gestation; however, it may induce various biological disturbances in maternal organism and on their fetuses. In this article the aim is bring on a subject for discussion on a case report. Keywords: Scorpion envenomation, pregnancy ÖzetEnvenomizasyon yani yılan veya akrep gibi zehirli sürüngen ve haşerelerle sokularak zehirlenme kurak iklimin hakim olduğu kırsal bölge halkı için ciddi bir risktir. Türkiye'de yapılan epidemiyolojik çalışmalar bu durumdan özellikle dişilerin etkilendiğine işaret etmektedir. Tanı ise anamneze bağlı olup ağrı, eritem, endurasyon ve belki haşerenin sokma noktasının görülmesine bağlıdır. Gebelikte envenomizasyon ise çok daha riskli olmasına rağmen üzerinde oldukça az çalışılmış bir konudur oysa ki hem maternal ve hem de fetal riskler söz konusudur. Biz bu yazımızda bir vakamızı literatür eşliğinde tartışmak istedik.

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Euscorpius (Scorpiones, Euscorpiidae): three cases of stings in northwestern Italy

Cited by 8 publications

References 14 publications

Stings from Euscorpius flavicaudis (De Geer, 1778) (Scorpiones, Euscorpiidae) during pregnancy: a clinical case report

Stings from Euscorpius flavicaudis (De Geer, 1778) (Scorpiones, Euscorpiidae) during pregnancy: a clinical case report

Pharmacokinetics and Biodistribution of Rhopalurus junceus Scorpion Venom in Tumor-Bearing Mice after Intravenous and Oral Administration

Scorpion sting during pregnancy: A case report accompanied by literature

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