European academy of dermatology and venereology European prurigo project: expert consensus on the definition, classification and terminology of chronic prurigo

Pereira, Manuel P.; Steinke, Sabine; Zeidler, Claudia; Forner, Caroline; Riepe, Claudia; Augustin, Matthias; Bobko, S.; Dalgard, Florence; Elberling, Jesper; Garcovich, Simone; Gieler, Uwe; Gonçalo, Margarida; Halvorsen, Jon Anders; Leslie, Tabi A.; Metz, Martin; Reich, Adam; Şavk, Ekin; Schneider, Gudrun; Serra‐Baldrich, E.; Ständer, Hartmut; Streit, Markus; Wallengren, Joanna; Weller, Karsten; Wollenberg, Andreas; Bruland, Philipp; Soto-Rey, Iñaki; Storck, Michael; Dugas, Martin; Weißhaar, Elke; Szepietowski, Jacek; Legat, Franz J.; Ständer, Sonja

doi:10.1111/jdv.14570

Cited by 170 publications

(220 citation statements)

References 11 publications

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“…1 The results of this survey also support the established finding that PN confers a heavy burden on patients and that these patients likely require more frequent use of healthcare resources. In particular, respondents indicated that the most urgent topics in PN are the need for consensus regarding the classification and terminology of the condition, and new therapies.…”

Section: Discussionsupporting

confidence: 78%

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Prurigo nodularis: a physician survey to evaluate current perceptions of its classification, clinical experience and unmet need

Pereira

Basta

Moore³

et al. 2018

Acad Dermatol Venereol

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Section: Discussionsupporting

confidence: 78%

“…1 PN is a long-term outcome of scratching by patients with chronic pruritus. 1 PN is a long-term outcome of scratching by patients with chronic pruritus.…”

Section: Introductionmentioning

confidence: 99%

Prurigo nodularis: a physician survey to evaluate current perceptions of its classification, clinical experience and unmet need

Pereira

Basta

Moore³

et al. 2018

Acad Dermatol Venereol

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“…For pruritus NRS, patients report average pruritus intensity (over the last 7 days) using an 11‐point scale (0–10, 0 = no itch and 10 = worst itch) . Prurigo nodules are hyperkeratotic, excoriated, pruritic nodules commonly associated with AD and chronic pruritus . As there are no standardized prurigo measures, we collected the following exploratory data on prurigo nodules: Presence/absence (0 = absent, 1 = present); number (<10, ≥10 to <100, ≥100); and size of most significant prurigo (diameter) (<2 mm, ≥2 to <4 mm, ≥4 to <8 mm, ≥8 mm).…”

Section: Methodsmentioning

confidence: 99%

Atopic dermatitis disease registry in Japanese adult patients with moderate to severe atopic dermatitis (ADDRESS‐J): Baseline characteristics, treatment history and disease burden

Katoh

Saeki

Kataoka

et al. 2019

The Journal of Dermatology

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Moderate to severe atopic dermatitis ( AD ) has a high disease burden and a significant effect on quality of life. Observational studies are necessary to determine the patient disease burden and long‐term disease control in the Japanese population. ADDRESS ‐J is a non‐interventional, observational registry of adult Japanese patients with moderate to severe AD . Herein, we report baseline data from the ADDRESS ‐J study describing disease characteristics and current treatment practices. At baseline, 300 adult AD patients with Investigator's Global Assessment ( IGA ) scores (range, 0–4) of 3 (moderate) or 4 (severe) whose treatments for AD were intensified, were assessed for clinical and patient‐reported outcomes and current AD treatments. The registry patients’ median age was 34.0 years; 60.7% were male and 71.7% had had AD for more than 20 years. At baseline, 220 study patients had an IGA score of 3 and 80 had an IGA score of 4. The median Eczema Area and Severity Index score was 21.7 (range, 0–72), the median body surface area involvement was 46.25%, and the median pruritus numerical rating scale score was 7.0 (range, 0–10); for each of these measures, higher scores represent greater severity. Most registry patients (86.7%) had recently used topical corticosteroids or topical calcineurin inhibitors as treatment for AD . This registry cohort represents a population of Japanese patients with moderate to severe AD and provides an important resource for characterizing the disease burden and evaluating the safety and effectiveness of various AD treatments.

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“…However, PCM is characterized by urticarial or solid pruriginous papules, which sometimes gather to form lichenified plaques; they are spread over the trunk and extremities with each eruption lasting for several weeks. Various etiologies, including dermatological, allergic, systemic, neurological, psychiatric/psychosomatic, multifactorial and unknown are thought to act as a trigger for itch and the development of various skin symptoms in chronic prurigo …”

Section: Introductionmentioning

confidence: 99%

Chronic prurigo: A retrospective study of 168 cases

Inui

Ugajin

Namiki

et al. 2020

The Journal of Dermatology

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Chronic prurigo is classified into two clinical subtypes: prurigo nodularis (PN) and prurigo chronica multiformis (PCM) in Japan. In this study, we retrospectively investigated the clinical features of 168 patients with chronic prurigo (103 with PN and 65 with PCM) diagnosed at the Tokyo Medical and Dental University, and compared age, sex, prevalence of comorbidities, blood test results, histology and treatment efficacy in both groups. We found that patients with PCM were significantly older than those with PN. Males were more frequently diagnosed with PCM than females; however, both sexes were similarly affected by PN. Chronic infection was more prevalent in PN, whereas diabetes was more common in PCM. For both subtypes, serum immunoglobulin E levels were elevated above the normal range. However, serum thymus and activation‐regulated chemokine/CCL17 levels and the number of blood eosinophils were significantly higher in patients with PCM than in those with PN. Histologically, much higher numbers of CD4+ cells than CD8+ cells were distributed in the lesions of both subtypes. Eosinophils were distributed predominantly in intracollagenous lesions in PCM but were observed mainly in perivascular lesions in PN. There were no differences in basophil and mast cell distributions in the lesions of the two groups. Treatment efficacy was also similar in both subtypes. Together, both subtypes exhibit inflammation patterns predominantly driven by T‐helper 2 cells. With respect to PCM, elevated numbers of blood eosinophils and the recruitment of these cells into intracollagenous areas may be important for pathogenesis.

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European academy of dermatology and venereology European prurigo project: expert consensus on the definition, classification and terminology of chronic prurigo

Cited by 170 publications

References 11 publications

Prurigo nodularis: a physician survey to evaluate current perceptions of its classification, clinical experience and unmet need

Prurigo nodularis: a physician survey to evaluate current perceptions of its classification, clinical experience and unmet need

Atopic dermatitis disease registry in Japanese adult patients with moderate to severe atopic dermatitis (ADDRESS‐J): Baseline characteristics, treatment history and disease burden

Chronic prurigo: A retrospective study of 168 cases

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