2019
DOI: 10.1021/acs.jnatprod.8b00939
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Abstract: During chronic inflammation, neutrophils acting locally as effector cells not only activate antibacterial defense but also promote the inflammatory response. Interleukin 8 (IL-8), the main cytokine produced by activated neutrophils, positively correlates with the severity of respiratory tract diseases. By screening European plants traditionally used for treating respiratory tract diseases, we found that extracts of aerial parts of Eupatorium cannabinum inhibit IL-8 release from neutrophils. Using bioassay-guid… Show more

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Cited by 12 publications
(11 citation statements)
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References 47 publications
(86 reference statements)
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“…Eupatoriopicrin also inhibited pro-inflammatory functions of neutrophils via suppression of IL-8 and TNF-α production (IC 50 < 1 μM) and p38 and ERK 1/2 MAP Kinases. In an in vivo assay, it suppressed neutrophil migration in a thioglycolate-induced inflammation model [ 56 ]. Furthermore, it produced inhibition of the MurA enzyme of Escherichia coli and Pseudomona aeruginosa [ 57 ].…”
Section: Biological Activitymentioning
confidence: 99%
See 1 more Smart Citation
“…Eupatoriopicrin also inhibited pro-inflammatory functions of neutrophils via suppression of IL-8 and TNF-α production (IC 50 < 1 μM) and p38 and ERK 1/2 MAP Kinases. In an in vivo assay, it suppressed neutrophil migration in a thioglycolate-induced inflammation model [ 56 ]. Furthermore, it produced inhibition of the MurA enzyme of Escherichia coli and Pseudomona aeruginosa [ 57 ].…”
Section: Biological Activitymentioning
confidence: 99%
“…Together with the activity reported for eupatoriopicrin, 5-deoxyeupatoriopicrin ( 64 ) from S. chamaedrys also demonstrated the capacity to suppress the production of inflammatory cytokines. [ 56 ].…”
Section: Biological Activitymentioning
confidence: 99%
“…The results are similar with previous studies showing that the ethanol extract of Inula helenium L. activates p38 mitogen-activated protein kinase (MAPK)/nuclear factor erythroid 2-related factor 2 (Nrf2)/heme oxygenase (HO-1) pathways in RAW264.7 cells, reducing inflammation in cecum ligation and puncture-induced septic mice [32]. Moreover, in another murine model of peritonitis, eupatoriopicrin, a compound found in Eupatorium species, efficiently suppressed LPS-induced phosphorylation of p38 MAPK and ERK and attenuated neutrophil infiltration [33].…”
Section: In Vitro Studiesmentioning
confidence: 99%
“…The major compounds responsible for these biological activities of E. japonicum have not been revealed yet. Since many sesquiterpene lactones with α -methylene γ -lactone ring are reported to regulate anti-inflammatory and anticancer targets [ 14 , 15 ] in order to validate the biological effects of E. japonicum extracts in relation to its chemical constituents eupatoriopicrin (10) , a germacranolide and 1-hydroxy-8-(4,5-dihydroxytigloyloxy)eudesma-4(15),11(13)-dien-6,12-olide (11) , an eudesmanolide were selected for the study of NO-inhibitory activity and cytotoxicity against human cancer stem cells (CSCs). Being disclosed as cytotoxic, the mechanism of cell death through apoptosis induction on CSCs would be examined using Hoechst 33342 staining, flow cytometry apoptosis analysis, and caspase-3 activity assays on NTERA-2 pluripotent human embryonal carcinoma cell line.…”
Section: Introductionmentioning
confidence: 99%