EuPA achieves visibility — An activity report on the first three years

Dunn, M. J.; Gil, Concha; Kleinhammer, Christian; Lottspeich, F.; Sanchez, Jean-Charles; Albar, Juan Pablo; Bini, Luca; Corrales, Fernando J.; Corthals, Garry L.; Fountoulakis, Michael; Hoogland, Christine; James, Peter; Jensen, Ole N.; Jiménez, Connie R.; Novo, Jesús V. Jorrín; Kraus, H-J; Meyer, Helmut E.; Noukakis, Dimitrios; Palagi, Patricia M.; Penque, Deborah; Quinn, Antony F.; Rabilloud, Thierry

doi:10.1016/j.jprot.2008.03.004

Cited by 5 publications

(5 citation statements)

References 5 publications

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“…Globally, about 1.8 million people died from diarrhoeal diseases, in 2005. Of these deaths, about one-fifth are likely due to food poisoning [2, 3]. Although food-borne illnesses are costly, they are preventable [4].…”

Section: Introductionmentioning

confidence: 99%

Food borne illness amongst health care workers, at a Central Hospital, Harare, Zimbabwe, 2016: a retrospective cohort study

Sithole

Juru

Chonzi³

et al. 2017

BMC Res Notes

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ObjectivesHealth care workers (HCW) at a Central Hospital, were served lunch at the hospital canteen on 12 December 2016. On 12 December 2016 at 1700 h, there was a sudden onset of symptoms suggestive of gastrointestinal illness among HCW. We conducted a retrospective cohort study to determine the cause and the factors associated with illness among the HCW at the hospital.ResultsWe interviewed 96 respondents. The median incubation period was 6 h (Q1 = 4; Q3 = 12). Abdominal pain (97.5%) and watery diarrhoea (95%) were the most common symptoms. The majority (97.5%) took antibiotics before collection of stool specimen for analysis, with 24 (60%) of 40 HCW treating themselves. Eating chicken (RR = 44.2, CI 74.07; 95.34) during lunch was associated with the illness. Staphylococcus aureus and Escherichia coli were isolated from food handlers’ hands, kitchen utensils and work surfaces. Staphylococcus aureus was isolated from chicken. None of food handlers had valid medical certificates. One out of four food handlers was formally trained.

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Section: Introductionmentioning

confidence: 99%

Food borne illness amongst health care workers, at a Central Hospital, Harare, Zimbabwe, 2016: a retrospective cohort study

Sithole

Juru

Chonzi³

et al. 2017

BMC Res Notes

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“…However, a large number of nuclear proteins resist such extraction under the mild conditions required for preserving protein function. Up to 10% of total nuclear protein remain insoluble even after extraction with 2 M salt, 1% Triton X-100, and nucleases and, in fact, these are the proteins that constitute the elusive and controversial “nuclear matrix” (Albrethsen et al 2008). Protein-protein interactions among these un-extractable proteins, as well as low affinity interactions, cannot be revealed with existing methodologies, yet they may be of fundamental importance in gene regulation, as suggested by the many studies that link nuclear organization with gene expression, development, and cellular memory.…”

Section: Future Directionsmentioning

confidence: 99%

Chromatin in the Nuclear Landscape

Beck

Bonasio²,

Kaneko³

et al. 2010

Cold Spring Harbor Symposia on Quantitative Biology

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“…In this context, we would like to point out the important contribution from Spanish Proteomic Society (SeProt), European Proteomic Society (EUPA) and HUPO to obtain the sequence of the human proteome. We aim to contribute with our future data from Hospital Niño Jesus using body fluids (such as bone marrow, peripheral blood) from children suffering cancer, and by collaboration with several international hospitals and research centers of prestige for this important labor, which will benefit children with poor prognoses as at present there is no correct therapy for all types of pediatric cancers [2–5].…”

Section: Introductionmentioning

confidence: 99%

Study of phosphorylation events for cancer diagnoses and treatment

Villar

Madero

López-Pascual

et al. 2015

Clinical & Translational Med

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The activation of signaling cascades in response to extracellular and intracellular stimuli to control cell growth, proliferation and survival, is orchestrated by protein kinases via phosphorylation. A critical issue is the study of the mechanisms of cancer cells for the development of more effective drugs. With the application of the new proteomic technologies, together with the advancement in the sequencing of the human proteome, patients will therefore be benefited by the discovery of novel therapeutic and/or diagnostic protein targets. Furthermore, the advances in proteomic approaches and the Human Proteome Organization (HUPO) have opened a new door which is helpful in the identification of patients at risk and towards improving current therapies. Modification of the signaling-networks via mutations or abnormal protein expression underlies the cause or consequence of many diseases including cancer. Resulting data is used to reveal connections between genes proteins and compounds and the related molecular pathways for underlining disease states. As a delegate of HUPO, for human proteome on children assays and studies, we, at Hospital Universitario Niño Jesús, are seeking to support the human proteome in this context. Clinical goals have to be clearly established and proteomics experts have to set up the appropriate proteomic strategy, which coupled to bioinformatics will make it possible to achieve new therapies for patients with poor prognosis. We envision to combine our up-coming data to the HUPO organization in order to support international efforts to advance the cure of cancer disease.

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EuPA achieves visibility — An activity report on the first three years

Cited by 5 publications

References 5 publications

Food borne illness amongst health care workers, at a Central Hospital, Harare, Zimbabwe, 2016: a retrospective cohort study

Food borne illness amongst health care workers, at a Central Hospital, Harare, Zimbabwe, 2016: a retrospective cohort study

Chromatin in the Nuclear Landscape

Study of phosphorylation events for cancer diagnoses and treatment

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