2015
DOI: 10.1080/21690731.2014.999576
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Eukaryote-specific extensions in ribosomal proteins of the small subunit: Structure and function

Abstract: Keywords: conserved ribosomal proteins, eukaryotic/yeast ribosome, eukaryote-specific extensions, eukaryotic translation initiation factors, protein synthesis, small ribosomal subunitHigh-resolution structures of yeast ribosomes have improved our understanding of the architecture and organization of eukaryotic rRNA and proteins, as well as eukaryote-specific extensions present in some conserved ribosomal proteins. Despite this progress, assignment of specific functions to individual proteins and/or eukaryotesp… Show more

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Cited by 5 publications
(13 citation statements)
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“…The ribosome is responsible for protein synthesis by tethered subunits (Orelle et al 2015). However, the upregulations of 40S and 60S ribosomal proteins were inconsistent with the reduced soluble protein content in the flowering phase in this study, perhaps the up-regulations of these proteins were related to other functions such as apoptosis, post-translational modifications and low-temperature stress (Ghosh and Komar 2015;Kim et al 2004). Several interesting signaling proteins including the 14-3-3 proteins (gi|302122828, gi|148612109, Table 3), calreticulin (gi|225450611, Table 3) and calmodulin (gi|255552670 , Table 3), rapid alkalinization factors (RALF, gi|357511919, Table 2), Ras-related protein RABB1c (gi|449443494, Table 2) also appeared to be differentially expressed.…”
Section: Discussioncontrasting
confidence: 74%
“…The ribosome is responsible for protein synthesis by tethered subunits (Orelle et al 2015). However, the upregulations of 40S and 60S ribosomal proteins were inconsistent with the reduced soluble protein content in the flowering phase in this study, perhaps the up-regulations of these proteins were related to other functions such as apoptosis, post-translational modifications and low-temperature stress (Ghosh and Komar 2015;Kim et al 2004). Several interesting signaling proteins including the 14-3-3 proteins (gi|302122828, gi|148612109, Table 3), calreticulin (gi|225450611, Table 3) and calmodulin (gi|255552670 , Table 3), rapid alkalinization factors (RALF, gi|357511919, Table 2), Ras-related protein RABB1c (gi|449443494, Table 2) also appeared to be differentially expressed.…”
Section: Discussioncontrasting
confidence: 74%
“…The remaining ribosomal proteins are unique to eukaryotes (Melnikov et al, 2012). Many of the universally conserved ribosomal proteins have also evolved eukaryote-specific extension segments (Melnikov et al, 2012;Ghosh and Komar, 2015). As a rule, these extension segments are present on the N-or C-terminal (or both) ends of the conserved proteins and vary widely in length, structure, and function (Ghosh and Komar, 2015).…”
Section: Introductionmentioning
confidence: 99%
“…Many of the universally conserved ribosomal proteins have also evolved eukaryote-specific extension segments (Melnikov et al, 2012;Ghosh and Komar, 2015). As a rule, these extension segments are present on the N-or C-terminal (or both) ends of the conserved proteins and vary widely in length, structure, and function (Ghosh and Komar, 2015). The extension segments are known to affect ribosome function/protein synthesis as a result of their interaction(s) with other ribosomal proteins, mRNA and/or the translation factors (Ghosh and Komar, 2015).…”
Section: Introductionmentioning
confidence: 99%
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