ETV6-PDGFRB and FIP1L1-PDGFRA stimulate human hematopoietic progenitor cell proliferation and differentiation into eosinophils: the role of nuclear factor- B

BCR-PDGFRA fusion in a T lymphoblastic leukemia/lymphoma

“…In our study, the metaphase FISH clearly showed that the aqua-labeled part of the probe was translocated on the der (22).…”

“…Previous studies indicate that PDGFRA rearrangements alone do not always result in up-regulation of eosinophil production in bone marrow, because additional conditions, such as overexpression of the nuclear factor kappa B or interleukin-5, are necessary (21,22). T-ALL is the rarest subtype of acute leukemia in adults.…”

Hematolymphoid Neoplasms Associated With Rearrangements of PDGFRA, PDGFRB, and FGFR1

“…The BM revealed AML without increased eosinophils. Conventional cytogenetic studies showed 46,XY,t(2;4)(p11.2;q12 [18]/46,XY [2]. FISH studies confirmed the involvement of PDGFRA and STRN (at 2p24).…”

“…17 It has been shown in human CD34+ cells that expression of FIP1L1-PDGFRA induces cell proliferation and differentiation toward eosinophilic lineage in the absence of cytokines; these effects are mediated by the activation of nuclear factor (NF)-kB and STAT5. 18 Although FIP1L1 is the most common partner of PDG-FRA, five other gene partners have been identified, including BCR, ETV6, KIF5B, STRN, and CDK5RAP2 (reviewed by Gotlib and Cools 14 ). The clinicopathologic features of cases with PDGFRA aberrations other than FIP1L1 have been reported in a very small number of cases and are apparently indistinguishable from those with FIP1L1-PDGFRA.…”

The molecular basis and clinical significance of genetic mutations identified in myelodysplastic syndromes

“…In this large cohort study, the prognostic value of such gene rearrangement in MDS was unable to be determined. Of note, ETV6 fusion with PDGFRB or IL3 may result in MPNs with eosinophilia [97,98].…”