Étude comparative de la protéine C-réactive et de la procalcitonine dans le diagnostic de sévérité des pyélonéphrites aiguës de l’enfant

Bouguila, J.; Khalef, I.; Charfeddine, B.; Rejeb, M Ben; Chatti, K.; Limam, K.; Essabbeh, H.; Essoussi, A. S.; Boughammoura, L.

doi:10.1016/j.patbio.2013.01.010

Cited by 8 publications

(5 citation statements)

References 22 publications

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“…Acute phase indexes like CRP , ESH and PCT levels, in children with urinary tract infection can be higher as it is the case in our study. It was reported in previous studies that PCT could be used as a more reliable index in comparison to CRP and ESH in determining acute pyelonephritis and kidney scar (13)(14)(15)(16). In our study, it was found that CRP , ESH and PCT levels in cases with UTI were higher.…”

Section: Discussionsupporting

confidence: 58%

“…C-reactive Protein (CRP) is recognized as a reliable method in differentiating bacterial and viral infections (1,(10)(11)(12)(13). Prokalsitonin (PCT), is acute phase reactant and considered as a new index for bacterial infections.…”

Section: Introductionmentioning

confidence: 99%

“…Prokalsitonin (PCT), is acute phase reactant and considered as a new index for bacterial infections. Previous studies reported that PCT could be used as a more reliable index in comparison to CRP and ESH in determining acute pyelonephritis and kidney damage (13)(14)(15)(16). Interleukin-6 (IL-6) has come into use as a sepsis index especially in neonatal.…”

Section: Introductionmentioning

confidence: 99%

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The Value of C-reactive Protein, Procalcitonin, Interleukin-6 Levels to Predict Urinary Tract Infection in Children with Fever without A Focus

Taşar¹,

Demır²,

Atay³

et al. 2014

J Pediatr Inf

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Objective: Urinary tract infections (UTIs) are one of the most common causes of acute fever without a focus in children between 1-36 months old, although obtaining urine for urine analysis is technically difficult in this age group. Therefore, there is a need for clinical and laboratory evidence to predict UTIs. The aim of this study is to determine the frequency of urinary tract infections in children between 1-36 months with acute fever of without a focus and the laboratory evidence, like C-reactive protein, procalcitonin, and interleukin-6 levels, that would help to predict urinary tract infections. Material and Methods: Febrile children presenting to a pediatric emergency department, ages ranging between 1-36 months old and body temperature being ≥38.0°C, with a source of fever that was undetectable clinically, were enrolled in this prospective study. Patients were evaluated according to clinical and laboratory findings. The data were analyzed using SPSS software, version 15.0. Results: A total of 90 patients were enrolled in this study. The median age was 7 months. The frequency of urinary tract infections was 25%. Escherichia coli was detected in all cases with positive urine cultures. There was no difference in clinical features between children with and without urinary tract infections. Laboratory findings, including white blood cell count, absolute neutrophil count, peripheral blood smear, and interleukin-6, were not statistically different between the two groups, whereas C-reactive protein and procalcitonin levels were significantly higher in the UTI group (p<0.05). Conclusion: In conclusion, UTI is a frequent infection in 1-36-month-old children with fever without a focus, and the urine test with urine culture must certainly be assessed in these children. Laboratory findings, including C-reactive protein and procalcitonin, can be used as supporting evidence. There is a need for large trials evaluating the value of interleukin-6 levels to predict urinary tract infections in children.(

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Section: Discussionsupporting

confidence: 58%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The Value of C-reactive Protein, Procalcitonin, Interleukin-6 Levels to Predict Urinary Tract Infection in Children with Fever without A Focus

Taşar¹,

Demır²,

Atay³

et al. 2014

J Pediatr Inf

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“…Until now, the commonly used laboratory inflammatory markers are WBC counts, ESR, CRP, and procalcitonin 16 17 18 19 . But, neither clinical parameters nor these inflammatory markers are able to reliably differentiate APN from lower UTI in infants and young children due to the lack of specificity 20 .…”

Section: Discussionmentioning

confidence: 99%

The value of delta neutrophil index in young infants with febrile urinary tract infection

Lee

Kim

Park

et al. 2017

Sci Rep

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Delta neutrophil index (DNI) is the fraction of circulating immature granulocytes, which reflects severe bacterial infections and septic condition but has not been studied in urinary tract infection (UTI). Here, we evaluated the value of DNI in predicting acute pyelonephritis (APN) or vesicoureteral reflux (VUR) using the data of 288 patients. Conventional inflammatory markers (white blood cell [WBC] count, erythrocyte sedimentation rate [ESR], C-reactive protein [CRP]), and DNI were measured. WBC, CRP, ESR and DNI were higher in APN than in lower UTI (p < 0.01). Multiple logistic-regression analyses showed that DNI was a predictive factor for areas of lack of uptake on dimercaptosuccinic acid (DMSA) scans (P < 0.01). The area under the receiver operating characteristic (AUC) was also high for DNI (0.622, 95% CI 0.558–0.687, P < 0.01) as well as for CRP (0.731, 95% CI 0.673–0.789, P < 0.01) for the prediction of DMSA defects. DNI demonstrated the highest area under the ROC curve for diagnosis of VUR (0.620, 95% CI 0.542–0.698, P < 0.01). To the best of our knowledge, this is a first study demonstrating that DNI can be used as a diagnostic marker to distinguish APN from lower UTI and function as a diagnostic marker indicative of VUR compared to other conventional markers.

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“…There are several studies examining potential accurate, noninvasive biomarkers for the ability to discriminate APN in children 5 6 7 8) . Several parameters of the systemic inflammatory response, including level of white blood cell (WBC) count, procalcitonin (PCT), c-reactive protein (CRP), and erythrocyte sedimentation rate (ESR), were not accurate enough to confidently differentiate 8 9) .…”

Section: Introductionmentioning

confidence: 99%

Usefulness of neutrophil-lymphocyte ratio in young children with febrile urinary tract infection

et al. 2016

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PurposeAcute pyelonephritis (APN) is a serious bacterial infection that can cause renal scarring in children. Early identification of APN is critical to improve treatment outcomes. The neutrophil-lymphocyte ratio (NLR) is a prognostic marker of many diseases, but it has not yet been established in urinary tract infection (UTI). The aim of this study was to determine whether NLR is a useful marker to predict APN or vesicoureteral reflux (VUR).MethodsWe retrospectively evaluated 298 pediatric patients (age≤36 months) with febrile UTI from January 2010 to December 2014. Conventional infection markers (white blood cell [WBC] count, erythrocyte sedimentation rate [ESR], C-reactive protein [CRP]), and NLR were measured.ResultsWBC, CRP, ESR, and NLR were higher in APN than in lower UTI (P<0.001). Multiple logistic regression analyses showed that NLR was a predictive factor for positive dimercaptosuccinic acid (DMSA) defects (P<0.001). The area under the receiver operating characteristic (ROC) curve was high for NLR (P<0.001) as well as CRP (P<0.001) for prediction of DMSA defects. NLR showed the highest area under the ROC curve for diagnosis of VUR (P<0.001).ConclusionNLR can be used as a diagnostic marker of APN with DMSA defect, showing better results than those of conventional markers for VUR prediction.

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Étude comparative de la protéine C-réactive et de la procalcitonine dans le diagnostic de sévérité des pyélonéphrites aiguës de l’enfant

Cited by 8 publications

References 22 publications

The Value of C-reactive Protein, Procalcitonin, Interleukin-6 Levels to Predict Urinary Tract Infection in Children with Fever without A Focus

The Value of C-reactive Protein, Procalcitonin, Interleukin-6 Levels to Predict Urinary Tract Infection in Children with Fever without A Focus

The value of delta neutrophil index in young infants with febrile urinary tract infection

Usefulness of neutrophil-lymphocyte ratio in young children with febrile urinary tract infection

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