Etiology of community-acquired pneumonia in children based on antibody responses to bacterial and viral antigens

Claesson, Bo A.; Trollfors, Birger; Brolin, I; Granström, Marta; Henrichsen, J.; Jodal, Ulf; Juto, Per; Kallings, Ingegerd; Kanclerski, Krzysztof; Lagergård, Teresa

doi:10.1097/00006454-198912000-00006

Cited by 147 publications

(86 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These results may corroborate previously reported etiological rates; in previous studies, the rate has been reported as 43% to 85% (14)(15)(16)(17)(18)(19)(20).…”

Section: Resultssupporting

confidence: 93%

Identification of respiratory viral infection agents by multiplex real-time PCR among children hospitalized for community-acquired pneumonia in Konya province

Sert¹,

Keşli²,

Odabaş³

et al. 2012

Turk Hij Den Biyol Derg

View full text Add to dashboard Cite

“…These results may corroborate previously reported etiological rates; in previous studies, the rate has been reported as 43% to 85% (14)(15)(16)(17)(18)(19)(20).…”

Section: Resultssupporting

confidence: 93%

Identification of respiratory viral infection agents by multiplex real-time PCR among children hospitalized for community-acquired pneumonia in Konya province

Sert¹,

Keşli²,

Odabaş³

et al. 2012

Turk Hij Den Biyol Derg

View full text Add to dashboard Cite

“…Thus, the most likely explanation for the elevated values in viral infections is secondary bacterial involvement, though not always demonstrable by antibody methods, especially in young children [14,21]. Based on the present and previous serological studies, mixed infections are common in children with respiratory syndromes [2,3,22].…”

Section: Discussionmentioning

confidence: 64%

White blood cells, C-reactive protein and erythrocyte sedimentation rate in pneumococcal pneumonia in children

Korppi

Heiskanen‐Kosma²,

Leinonen³

1997

Eur Respir J

145

109

View full text Add to dashboard Cite

White blood cells, C-reactive protein and erythrocyte sedimentation rate in pneumococcal pneumonia in children. M. Korppi, T. Heiskanen-Kosma, M. Leinonen. ©ERS Journals Ltd 1997. ABSTRACT: We evaluated the applicability of C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), white blood cell count (WBC), and absolute neutrophil count (ANC), in the screening of pneumococcal (PNC) pneumonia in children.In 1981-1982, 161 children were treated for radiologically verified communityacquired pneumonia in the hospital during a period of 12 months. The Streptococcus pneumoniae aetiology of infection was studied by antigen, antibody and immune complex assays in acute and convalescent sera. In acute blood samples, CRP was measured by the immunonephelometric method, ESR by the Westergren method, WBC using an automatic cell counter, and thereafter the ANC was calculated after microscopic examination of peripheral smears.CRP and ESR were significantly higher in patients with alveolar (n=53) than in those with interstitial (n=108) pneumonia. CRP, ESR and ANC were significantly higher in PNC (n=29) than in viral (n=23) pneumonia. The values in mixed PNC and viral infections (n=17) were approximately midway between PNC and viral cases. All cases with serologic evidence of S. pneumoniae aetiology were combined (n=46) for calculation of diagnostic parameters. When a cut-off limit of 60 mg·L -1 was used, CRP had a sensitivity of 26% and a specificity of 83% in the screening of PNC pneumonia.We conclude that C-reactive protein and erythrocyte sedimentation rate have a limited capacity to differentiate between pneumococcal and nonpneumococcal pneumonia. C-reactive protein is recommended as the first-line method of screening, and the value of 60 mg·L -1 as the cut-off limit. Eur Respir J 1997; 10: 1125-1129

show abstract

“…The frequency of claims was converted into a frequency of pneumonia episodes using the average number of medical visits (n=2.2) recorded in our retrospective study of cases of pneumonia in children younger than 10 years of age in Quebec and Manitoba (from the microcosting study of otitis and pneumonia described later). The proportion of pneumonia attributable to S pneumoniae was set at 22% based on values found in published studies (9)(10)(11)(12)(13)(14)(15)(16).…”

Section: Methodsmentioning

confidence: 99%

Epidemiological and Economic Burden of Pneumococcal Disease in Canadian Children

Petit

Wals

Law

et al. 2003

Canadian Journal of Infectious Diseases and Medical Microbiolog

View full text Add to dashboard Cite

BACKGROUND: With the arrival of a new conjugate pneumococcal vaccine, it is important to estimate the burden of pneumococcal diseases in Canadian children. The epidemiological data and the economic cost of these diseases are crucial elements in evaluating the relevance of a vaccination program. METHODS: Using provincial databases, ad hoc surveys and published data, age-specific incidence rates of pneumococcal infections were estimated in a cohort of 340,000 children between six months and nine years of age. The costs of these diseases to the health system and to families were also evaluated using data from Quebec and Manitoba. RESULTS: Cumulative risks were one in 5000 for pneumococcal meningitis, one in 500 for bacteremia and one in 20 for pneumonia, leading to 16 deaths in the cohort. About 262,000 otitis media episodes and 32,000 cases of myringotomy with ventilation tube insertion were attributable to Streptococcus pneumoniae. Societal costs were estimated at $125 million, of which 32% was borne by the health system and 68% was borne by families. Invasive infections represented only 2% of total costs, while 84% were generated by otitis media. CONCLUSION: Pneumococcal infections represent a significant burden for Canadian children and society that could be significantly reduced through immunization.

show abstract

Etiology of community-acquired pneumonia in children based on antibody responses to bacterial and viral antigens

Cited by 147 publications

References 0 publications

Identification of respiratory viral infection agents by multiplex real-time PCR among children hospitalized for community-acquired pneumonia in Konya province

Identification of respiratory viral infection agents by multiplex real-time PCR among children hospitalized for community-acquired pneumonia in Konya province

White blood cells, C-reactive protein and erythrocyte sedimentation rate in pneumococcal pneumonia in children

Epidemiological and Economic Burden of Pneumococcal Disease in Canadian Children

Contact Info

Product

Resources

About