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“…Savage et al [14] in their study of 300 hospitalized patients in a New York City teaching hospital have reported drug therapy and alcohol abuse as the most frequent causes, and Vitamin B12/folate deficiency as uncommon (6%). Davidson et al [7] have also reported medications as the most frequent cause.…”
Section: Discussionmentioning
“…On the other hand, alcohol abuse was the most common cause of macrocytosis as per Colon-Otero, followed by vitamin B 12 and folate defi ciency [9]. In the large study by Savage et al in 2000, the most common cause of macrocytosis was drug therapy, followed by alcohol liver disease, and reticulocytosis [11]. Megaloblastic hematopoiesis accounted for less than 10% of his cases, with cobalamin or folate defi ciency being present in only 6% of patients.…”
Section: Etiology Of Macrocytic Anemiamentioning
“…Even though macrocytosis is considered a diagnostic, increased MCV values are in most cases related to other conditions such as drugs and alcohol abuse. Cobalamin and folate deficiencies have been shown to be responsible for macrocytosis in only about 6% of cases (44) . Macrocytic anaemia is therefore not mandatory.…”
Section: Clinical Symptoms and Diagnosismentioning
“…5 Macrocytosis can be seen in many hematological and non-hematological disorders and more than one cause may co-exist in an individual. Serum vitamin B 12 and folic acid tests are routinely ordered but they are limited by their low sensitivity and specificity.…”
mentioning
“…[1] Other studies have suggested the role of tissue folate deficiency as a causative factor . [4] Early B12 deficiency and alcoholism show uniform macrocytes as compared to the macro ovalocytes in full fledged megaloblastic anemia. [5] Acute leukemias accounts for a considerable chunk of group A.…”
Section: Discussionmentioning