Etiology and clinical characteristics of pediatric acute pancreatitis in Saudi Arabia

Alabdulkareem, Abdulrahman; Almahmoud, Tameem; Altahan, Husam; Javad, Sundas; Hatlani, Maher Al

doi:10.1016/j.ijpam.2018.01.001

Cited by 13 publications

(12 citation statements)

References 34 publications

(35 reference statements)

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“…The present study aimed to describe a baseline for AP in children in the northeastern part of India by defining the etiological factors, clinical presentation, hospital stay, and imaging findings among all cases of primary disease identified at our institute. AP in children was diagnosed at a rate of 12-13 cases per year in the present study, which is very high compared to a recent study conducted by Alabdulkareem et al where the annual rate of the occurrence of AP was 2-3 cases on an average [13].…”

Section: Discussioncontrasting

confidence: 64%

Risk Factors, Clinical Features, and Outcomes of Acute Pancreatitis in Children in Endemic Zone of Ascariasis in Eastern Bihar: A Hospital-Based Study

Bhattacharya¹,

Kumar²,

Kumari³

et al. 2022

Cureus

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This study aims to describe the etiology, clinical features, and outcomes of acute pancreatitis (AP) in children in an endemic area of hepatobiliary ascariasis. MethodsThis retrospective observational study included acute pancreatitis (AP) patients in the age group of 2-15 years from January 2019 to January 2022. Demographic profile, risk factors, clinical features, laboratory imaging, and outcome data were collected and analyzed. ResultsA total of 40 patients comprising of 21 males (52.5%) and 19 females (47.5%) were included. The median age of the diagnosis of AP was 8.3 years (range: 4-14 years). Biliary ascariasis was the most frequent etiology of AP (n=18, 45%), followed by gallbladder (GB) stone (n=6, 12%), trauma (n=1, 2.5%), hepatitis (n=1, 2.5%), valproate drug (n=1, 2.5%), and GB sludge (n=1, 2.5%). In clinical features, all cases had pain in the abdomen (n=40, 100%), followed by fever (n=9, 22.5%), nausea/vomiting (n=33, 82.5%), jaundice (n=2, 5%), and anemia (n=2, 5%). Three (7.5%) patients developed complications such as shock, pseudocyst, and necrotizing pancreatitis, respectively. The average median hospital stay was nine days (range: 4-20 days). No mortality occurred in our study. ConclusionsThis study revealed a high prevalence (12-13 cases/year) of AP in children in this area. Biliary ascariasis (45%) emerged as the commonest risk factor. Most of the cases suffered from mild AP (92%) and so recovered completely without any complication.

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Section: Discussioncontrasting

confidence: 64%

Risk Factors, Clinical Features, and Outcomes of Acute Pancreatitis in Children in Endemic Zone of Ascariasis in Eastern Bihar: A Hospital-Based Study

Bhattacharya¹,

Kumar²,

Kumari³

et al. 2022

Cureus

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“…For AP with specific causes, such as bile duct stones, anatomical abnormalities, bile duct dilatation, etc., it has been suggested that surgery should be performed as soon as possible after the condition is controlled and stable, to prevent recurrence [ 11 , 21 ]. No child died in our research data.…”

Section: Discussionmentioning

confidence: 99%

Clinical characteristics of acute pancreatitis in children: a single-center experience in Western China

et al. 2021

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Background The diagnosis of pediatric pancreatitis has been increasing over the last 20 years. We aimed to compare the clinical characteristics for pediatric acute pancreatitis (AP) with adult AP, and investigate the risk factor for acute recurrent pancreatitis (ARP) in children. Method From June 2013 to June 2019, a total of 130 pediatric patients with AP at the inpatient database were enrolled. Univariate analysis and multivariate Cox regression analysis were performed to identify the risk factors for ARP in children. Result Major etiologic factors in 130 patients were biliary (31.5%), idiopathic (28.5%). The etiology of pancreatitis in children was markedly different from that in adults (p < 0.001). Compared with the adult patients, the pediatric patients had significantly lower severity (p = 0.018) and occurrence rate of pancreatic necrosis (p = 0.041), SIRS (p = 0.021), acute peripancreatic fluid collection (p = 0.014). Univariate and Multivariate Cox regression analysis showed that female (p = 0.020; OR 3.821; 95% CI 1.231–11.861), hypertriglyceridemia (p = 0.045; OR 3.111; 95% CI 1.024–9.447), pancreatic necrosis (p = 0.023; OR 5.768; 95% CI 1.278–26.034) were the independent risk factors of ARP. Hypertriglyceridemia AP had the highest risk of recurrence compared to other etiology (p = 0.035). Conclusion Biliary and idiopathic disease were the major etiologies of AP in children. Children have simpler conditions than adults. Female, hypertriglyceridemia, and pancreatic necrosis were associated with the onset of ARP.

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“…and pancreas divisum (6%) (11). In our study, infections were found to be the most common cause of acute pancreatitis following idiopathic reasons whereas hereditary causes were found to be more common in acute recurrent and chronic pancreatitis groups following idiopathic causes.…”

Section: Discussionmentioning

confidence: 42%

Çocuklarda Pankreatit: Tek Merkez Deneyimi

Bükülmez¹,

Balikoğlu²,

Oflu³

et al. 2020

Turkish Journal of Pediatric Disease

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Objective: The aim of this study was to evaluate the clinical, laboratory and etiological differences between children having acute pancreatitis, acute recurrent pancreatitis and chronic pancreatitis.Material and Methods: Medical records of children who were diagnosed with pancreatitis between January 2014 and December 2017 were evaluated retrospectively. The study was approved by the Ethics Committee of Afyonkarahisar University of Health Sciences.Our cases were classified as acute pancreatitis, acute recurrent pancreatitis and chronic pancretitis according to INSPPIRE group definitions.Results: Etiology, demographic characteristics, laboratory and radiological findings were compared between acute pancreatitis (group 1) and acute recurrent and chronic pancreatitis (group 2) groups. 43 patients (78.2%) were enrolled in acute pancreatitis group (group 1). In group 2; 8 cases had acute recurrent pancreatitis and 4 cases had chronic pancreatitis [a total of 12 cases (21.8%)].When the etiologies of our cases were examined; Group 1 had idiopathic (88.5%), stone (2.3%), trauma (2.3%), infections (4.6%) and choledochal cyst (2.3%), respectively. In group 2, they were found to be idiopathic (50%), congenital anomalies of the pancreatic duct (8.3%), allergy (8.3%), autoimmunity (8.3%) and genetic causes (25%).There was no statistical difference between the groups in terms of laboratory values. In our study, the cause of pancreatitis could not be generally identified in all groups. Conclusion:In cases having acute pancreatitis, infections were the second most common etiology; and common causes of acute recurrent and chronic pancreatitis have been found as genetic causes.

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Etiology and clinical characteristics of pediatric acute pancreatitis in Saudi Arabia

Cited by 13 publications

References 34 publications

Risk Factors, Clinical Features, and Outcomes of Acute Pancreatitis in Children in Endemic Zone of Ascariasis in Eastern Bihar: A Hospital-Based Study

Risk Factors, Clinical Features, and Outcomes of Acute Pancreatitis in Children in Endemic Zone of Ascariasis in Eastern Bihar: A Hospital-Based Study

Clinical characteristics of acute pancreatitis in children: a single-center experience in Western China

Çocuklarda Pankreatit: Tek Merkez Deneyimi

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