Ethoxyresorufin-O-deethylase (EROD) and vitellogenin (VTG) in flounder (Platichthys flesus): System interaction, crosstalk and implications for monitoring

Kirby, Mark F.; Smith, Andy; Rooke, Julianne; Neall, Paula; Scott, Alexander P.; Katsiadaki, Ioanna

doi:10.1016/j.aquatox.2006.12.004

Cited by 66 publications

(39 citation statements)

References 41 publications

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“…( p < 0.05), but not relative to other controls. This finding is in agreement with previous observations that exposure to estrogenic agents decreases EROD activity [21] and inhibits the induction of CYP1A by PAH [22]. Treatment of striped bass with SPMD extracts had no significant effect on EROD activity.…”

Section: Erod Activitysupporting

confidence: 94%

“…Although elevated levels of VTG have been associated with decreased fecundity and male feminization, whether the level of VTG induction found in the current study would alter such reproductive phenotypes is unknown. As is discussed later, observations that levels of estrogenic agents can markedly inhibit EROD induction by PAHs [21,22], potentially may be of greater concern.…”

Section: Vitellogeninmentioning

confidence: 96%

Section: Interactionsmentioning

confidence: 99%

“…The activity of EROD and CYP1A induction can be inhibited by many environmentally relevant compounds, including estrogens, glucocorticoids, imidazole antifungal pesticides, PBDEs, Cd, Cu, and certain pharmaceuticals [10,22,30]. Of even greater concern are observations that levels of estrogenic agents well below that required to induce VTG can markedly inhibit EROD induction by PAHs [21,22]. The current finding that E2 treatment decreased EROD levels also agrees with data showing that estrogenic agents including ethinyl estradiol and p-nonylphenol also inhibit EROD induction [21,22].…”

Section: Interactionsmentioning

confidence: 99%

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Environmental contaminant effects on juvenile striped bass in the San Francisco Estuary, California, USA

Spearow

Kota

Ostrach

2010

Enviro Toxic and Chemistry

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The decline of pelagic organisms in the San Francisco Estuary (SFE) (California, USA) is attributed to several factors, including water diversions, invasive species, and exposure to environmental toxicants. The present study evaluated the effects of environmental contaminants on liver vitellogenin, metallothionein, 7-ethoxyresorufin-O-deethylase (EROD), and benzyloxyresorufin O-deethylase (BROD) activity in juvenile striped bass (Morone saxitilis) in the SFE. Analysis of juvenile striped bass liver extracts revealed site-specific elevations of vitellogenin, metallothionein, and EROD biomarkers across the estuary. Although some striped bass in the estuary showed EROD activity similar to unhandled hatchery controls, several sites in the estuary showed significantly higher EROD activity that was in the range of beta-naphthoflavone (BNF)-injected, positive controls. Overall, EROD activity averaged 283% higher in estuary fish than in hatchery controls. Chemical analyses of extracts from semipermeable membrane devices (SPMDs) deployed in the estuary for one month showed elevated polyaromatic hydrocarbon (PAH) levels. Semipermeable membrane devices extract injections-induced metallothionein and BROD in striped bass livers. These data show that environmental exposures are impacting EROD and other biomarkers in the SFE striped bass population. Previous studies in our laboratory have associated poor larval development with maternal transfer of environmental contaminants. Further studies are needed to monitor contaminant exposures by the use of biomarkers and to integrate them into a more effective pelagic species recovery plan in the SFE.

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Section: Erod Activitysupporting

confidence: 94%

Section: Vitellogeninmentioning

confidence: 96%

Section: Interactionsmentioning

confidence: 99%

Section: Interactionsmentioning

confidence: 99%

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Environmental contaminant effects on juvenile striped bass in the San Francisco Estuary, California, USA

Spearow

Kota

Ostrach

2010

Enviro Toxic and Chemistry

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“…Wherein at low concentrations there is EROD induction but beyond the optimal level PAH are stressful and produce death. Thus, the concentration and duration of the toxin exposure are factors for EROD induction (Pohl and Fouts 1980;Shimada et al 2003;Kirby et al 2007). …”

Section: Impact Of Water Parameters On the Enzyme Activitymentioning

confidence: 99%

Effect of temperature, salinity, pH and naphthalene on ethoxyresorufin-O-deethylase activity ofOreochromis mossambicus

Amutha

Subramanian

2010

Toxicological & Environmental Chemistry

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Hepatic ethoxyresorufin-O-deethylase (EROD) activity of Oreochromis mossambicus was examined in response to naphthalene, a polycyclic aromatic hydrocarbon (PAH) as a bioindicator of exposure. This study also examined the effects of varying water parameters such as salinity, temperature, and pH on this fish model. Temperature, salinity, and pH produced cyclic changes in EROD activity which increases and/or decreases. After exposure to lower naphthalene concentrations up to 6 ppm, no marked change in activity was noted, whereas at higher concentrations EROD activity was increased. Data suggest that EROD measurement may be useful as a potential biomarker for the detection of hydrocarbon pollution.

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Fish Vitellogenin as a Biological Effect Marker of Oestrogenic Endocrine Disruption in the Open Sea

Scott

Robinson

2008

Advances in Fisheries Science

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Ethoxyresorufin-O-deethylase (EROD) and vitellogenin (VTG) in flounder (Platichthys flesus): System interaction, crosstalk and implications for monitoring

Cited by 66 publications

References 41 publications

Environmental contaminant effects on juvenile striped bass in the San Francisco Estuary, California, USA

Environmental contaminant effects on juvenile striped bass in the San Francisco Estuary, California, USA

Effect of temperature, salinity, pH and naphthalene on ethoxyresorufin-O-deethylase activity ofOreochromis mossambicus

Fish Vitellogenin as a Biological Effect Marker of Oestrogenic Endocrine Disruption in the Open Sea

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