Ethosuximide, sodium valproate or lamotrigine for absence seizures in children and adolescents

Abstract

BackgroundThis is an updated version of the original Cochrane review originally published in 2003, Issue 3, and updated in 2005, Issue 4.Absence seizures are brief epileptic seizures which present in childhood and adolescence. Depending on clinical features and electroencephalogram (EEG) findings they are divided into typical, atypical absences, and absences with special features. Typical absences are characterised by sudden loss of awareness and an EEG typically shows generalised spike wave discharges at three cycles per second. Ethosuximide, valproate and lamotrigine are currently used to treat absence seizures. This review aims to determine the best choice of antiepileptic drug for children and adolescents with typical absence seizures. Ethosuximide, sodium valproate or lamotrigine for absence seizures in children and adolescents (Review)

Lamotrigine versus valproic acid monotherapy for generalised epilepsy: A meta-analysis of comparative studies

“…However, there was no significant difference between treatment groups in terms of analysis adverse effects. This result was inconsistent with metaanalysis by Brigo et al [30]. They demonstrated that more adverse events occurred in the VPA group.…”

Lamotrigine versus valproic acid monotherapy for generalised epilepsy: A meta-analysis of comparative studies

“…However, there was no significant difference between treatment groups in terms of analysis adverse effects. This result was inconsistent with metaanalysis by Brigo et al [30]. They demonstrated that more adverse events occurred in the VPA group.…”

Evaluation of the Detrimental Effects of some Antiepileptic Drugs on the Height and Weight of Children with Epilepsy

“…Carbamazepine had no significant influence on growth, centile-weight, or centile-height. This might be due to the drug's mini effect on resting metabolic rate, as reported by Herman et al, (11) ; however, this does not go with Inaloo et al, 2020 (12) .…”

Temporal and Potential Predictive Relationships between Sleep Spindle Density and Spike-and-Wave Discharges

“…The effect of antiepileptic treatment on sleep spindles using ethosuximide ( Glauser et al, 2013 ; Brigo and Igwe, 2017 ; Kozák et al, 2020 ), which is the first-line treatment for absence seizures in humans in addition to the established genetic rodent models WAG/Rij and GAERS, was also investigated. Ethosuximide was administered to epileptic PV-ArchT mice at a dose of 100 mg/kg intraperitoneally.…”

Lamotrigine versus valproic acid monotherapy for generalised epilepsy: A meta-analysis of comparative studies

“…However, there was no significant difference between treatment groups in terms of analysis adverse effects. This result was inconsistent with metaanalysis by Brigo et al [30]. They demonstrated that more adverse events occurred in the VPA group.…”

Evaluation of the Detrimental Effects of some Antiepileptic Drugs on the Height and Weight of Children with Epilepsy

“…Carbamazepine had no significant influence on growth, centile-weight, or centile-height. This might be due to the drug's mini effect on resting metabolic rate, as reported by Herman et al, (11) ; however, this does not go with Inaloo et al, 2020 (12) .…”

Temporal and Potential Predictive Relationships between Sleep Spindle Density and Spike-and-Wave Discharges

“…The effect of antiepileptic treatment on sleep spindles using ethosuximide ( Glauser et al, 2013 ; Brigo and Igwe, 2017 ; Kozák et al, 2020 ), which is the first-line treatment for absence seizures in humans in addition to the established genetic rodent models WAG/Rij and GAERS, was also investigated. Ethosuximide was administered to epileptic PV-ArchT mice at a dose of 100 mg/kg intraperitoneally.…”

Lamotrigine versus valproic acid monotherapy for generalised epilepsy: A meta-analysis of comparative studies

“…However, there was no significant difference between treatment groups in terms of analysis adverse effects. This result was inconsistent with metaanalysis by Brigo et al [30]. They demonstrated that more adverse events occurred in the VPA group.…”

Evaluation of the Detrimental Effects of some Antiepileptic Drugs on the Height and Weight of Children with Epilepsy

“…Carbamazepine had no significant influence on growth, centile-weight, or centile-height. This might be due to the drug's mini effect on resting metabolic rate, as reported by Herman et al, (11) ; however, this does not go with Inaloo et al, 2020 (12) .…”

Temporal and Potential Predictive Relationships between Sleep Spindle Density and Spike-and-Wave Discharges

“…The effect of antiepileptic treatment on sleep spindles using ethosuximide ( Glauser et al, 2013 ; Brigo and Igwe, 2017 ; Kozák et al, 2020 ), which is the first-line treatment for absence seizures in humans in addition to the established genetic rodent models WAG/Rij and GAERS, was also investigated. Ethosuximide was administered to epileptic PV-ArchT mice at a dose of 100 mg/kg intraperitoneally.…”