Ethosuximide‐induced Stevens‐Johnson syndrome/toxic epidermal necrolysis overlap confirmed by patch testing in a child

Patch testing for cutaneous adverse drug reactions in a paediatric population: A retrospective review

“…Exanthema from other causes, such as infections or complex interactions between drugs and virus are pointed as one of the main reasons for the low PT sensitivity in MPE 1,6,9,10 . Regarding SCARs, the sensitivity is related mainly to the involved drugs (higher with anticonvulsants) and because the probability of a positive PT increases with the severity of the CADRs, as shown in several studies 5,7,9 …”

“…[2][3][4][5][6] This may be related to the lower incidence of CADRs in children, the lack of PT standardization especially for severe cutaneous adverse reactions (SCARs) and controversies on PT safety, particularly in this population. [3][4][5]7 This study aimed to evaluate the sensitivity and safety of PT for paediatric CADRs. suspected culprit and related drugs were patch tested mostly at 10% in pet., according to ESCD recommendations, and as in previous studies reported from our department.…”

“…Patch tests (PT) are considered useful for diagnosing non‐immediate CADRs, however, few paediatric studies have been published 2–6 . This may be related to the lower incidence of CADRs in children, the lack of PT standardization especially for severe cutaneous adverse reactions (SCARs) and controversies on PT safety, particularly in this population 3–5,7 . This study aimed to evaluate the sensitivity and safety of PT for paediatric CADRs.…”

Stevens-Johnson syndrome/toxic epidermal necrolysis overlap triggered by ethosuximide: a rare pediatric report

“…Epicutaneous patch tests performed with a reduced Portuguese/European Baseline series, an antiepileptic series, and ethosuximide (a drop of the gel contained in the capsule as is and diluted at 10% in petrolatum) showed a strongly positive reaction (2+) to ethosuximide, whereas no reaction was observed on controls 8 . A skin biopsy was not performed.…”