Ethnobotanical approach versus random approach in the search for new bioactive compounds: Support of a hypothesis

Gyllenhaal, Charlotte; Kadushin, Marian R.; Southavong, B.; Sydara, Kongmany; Bouamanivong, Somsanith; Xaiveu, M.; Xuan, Le Thi; Hiệp, Nguyễn Tiến; Hùng, Nguyễn Văn; Loc, Phan Ke; Dac, L.X.; Bich, Truong Quang; Cường, Nguyễn Mạnh; Ly, Ho Minh; Zhang, Hongjie; Franzblau, Scott G.; Xie, Hui; Riley, Mary; Elkington, Bethany Gwen; Nguyen, Hoa; Waller, Donald P.; Y., C.; Tamez, Pamela A.; Tan, Ghee Teng; Pezzuto, John M.; Soejarto, Djaja D.

doi:10.3109/13880209.2011.634424

Cited by 48 publications

(34 citation statements)

References 26 publications

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“…The discovery of these pharmacologically active constituents was usually based on ethnobotanical information, and many drugs used today were developed from medicinal plants employed in indigenous societies, 75) e.g., Gyllenhaal et al compared the ethnobotanical and random approaches in the search for new bioactive compounds. 77) The results indicated that ethnomedicinal uses may contribute to a higher rate of activity in drug discovery screening. There were several other reasons supporting the discovery of pharmacologically active ingredients from TMPs via modern ethnobotany: 1) Ethnobotanical inquiry can provide abundant materials for laboratory experiments.…”

Section: Modern Ethnobotany and Pharmacol-ogically Active Constituentmentioning

confidence: 87%

Prospecting for Bioactive Constituents from Traditional Medicinal Plants through Ethnobotanical Approaches

Wang

Long

et al. 2014

Biological & Pharmaceutical Bulletin

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Pharmacologically active constituents from traditional medicinal plants have received great attention as sources of novel agents, pharmaceutical intermediates, and chemical entities for synthetic or semisynthetic drugs due to their potent pharmacological activities, low toxicity, and economic viability. Numerous components have been isolated from traditional medicinal plants, including alkaloids, flavonoids, and terpenoids, and clinical and experimental studies suggested that these components have useful pharmacological properties such as antiinfectious, antioxidative, and antiinflammatory effects. In this review, modern ethnobotanical approaches to explore folk medicinal plants as candidates for drug discovery with the greatest possibility of success are discussed. Determining the bioactive mechanisms and tracing structure-activity relationships will promote the discovery of new drugs and pharmacological agents.

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Section: Modern Ethnobotany and Pharmacol-ogically Active Constituentmentioning

confidence: 87%

Prospecting for Bioactive Constituents from Traditional Medicinal Plants through Ethnobotanical Approaches

Wang

Long

et al. 2014

Biological & Pharmaceutical Bulletin

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“…This is also the point where the story usually ends as only few claims observed in vitro can be repeated in vivo (Gertsch, 2009). The matching of ethnomedical indications with biological test systems is not always straightforward and many plant species and crude drugs are indicated and applied for different diseases and symptoms at the same time within one culture and even to a greater extend between different cultures (Spjut, 2005; Gyllenhaal et al, 2012). Moreover, ethnopharmacopoeias are cultural constructs and in constant exchange and transformation.…”

Section: Challenges In Ethnopharmacologymentioning

confidence: 99%

Traditional medicines and globalization: current and future perspectives in ethnopharmacology

Leonti¹,

Casu²

2013

Front. Pharmacol.

168

111

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The ethnopharmacological approach toward the understanding and appraisal of traditional and herbal medicines is characterized by the inclusions of the social as well as the natural sciences. Anthropological field-observations describing the local use of nature-derived medicines are the basis for ethnopharmacological enquiries. The multidisciplinary scientific validation of indigenous drugs is of relevance to modern societies at large and helps to sustain local health care practices. Especially with respect to therapies related to aging related, chronic and infectious diseases traditional medicines offer promising alternatives to biomedicine. Bioassays applied in ethnopharmacology represent the molecular characteristics and complexities of the disease or symptoms for which an indigenous drug is used in “traditional” medicine to variable depth and extent. One-dimensional in vitro approaches rarely cope with the complexity of human diseases and ignore the concept of polypharmacological synergies. The recent focus on holistic approaches and systems biology in medicinal plant research represents the trend toward the description and the understanding of complex multi-parameter systems. Ethnopharmacopoeias are non-static cultural constructs shaped by belief and knowledge systems. Intensified globalization and economic liberalism currently accelerates the interchange between local and global pharmacopoeias via international trade, television, the World Wide Web and print media. The increased infiltration of newly generated biomedical knowledge and introduction of “foreign” medicines into local pharmacopoeias leads to syncretic developments and generates a feedback loop. While modern and post-modern cultures and knowledge systems adapt and transform the global impact, they become more relevant for ethnopharmacology. Moreover, what is traditional, alternative or complementary medicine depends on the adopted historic-cultural perspective.

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“…In order to explore the medical potential of plants, there has been some debate over whether or not traditional medicinal plants are any more likely than randomly chosen plants to contain compounds that act against microbial targets (Balick, 1990; Cragg et al, 1994; Gyllenhaal et al, 2012; Lewis and Elvin-Lewis, 1995; Saslis-Lagoudakis et al, 2012). In a review by Gyllenhaal et al (2012), it was shown that plants that were used traditionally to treat symptoms of tuberculosis in Laos were significantly more likely to yield active test results against mycobacteria than plants chosen at random.…”

Section: Introductionmentioning

confidence: 99%

“…In a review by Gyllenhaal et al (2012), it was shown that plants that were used traditionally to treat symptoms of tuberculosis in Laos were significantly more likely to yield active test results against mycobacteria than plants chosen at random.…”

Section: Introductionmentioning

confidence: 99%

New finding of an anti-TB compound in the genus Marsypopetalum (Annonaceae) from a traditional herbal remedy of Laos

Elkington

Sydara²,

Newsome

et al. 2014

Journal of Ethnopharmacology

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Ethnopharmacological relevance There is widespread use of traditional herbal remedies in the Lao PDR (Laos). It is common practice to treat many diseases with local plants. This research project documented and analysed some of these traditional remedies used to treat symptoms of tuberculosis (TB). Materials and methods This research was executed by interviewing healers about plants used traditionally to treat the symptoms of TB. Samples of some of the plants were collected, and extracts of 77 species were submitted to various in vitro assays in order to determine the amount of growth inhibition of virulent Mycobacterium tuberculosis H37Rv (Mtb), as opposed to other microbes and mammalian Vero cells. Results Interviews took place with 58 contemporary healers in 5 different provinces about plants currently used, giving a list of 341 plants. Bioassay-guided fractionation was performed on Marsypopetalum modestum (Pierre) B. Xue & R.M.K. Saunders (Annonaceae), leading to the isolation of dipyrithione, an anti-mycobacterial compound isolated for the first time from the genus Marsypopetalum through this research. Conclusions This research has helped to increase awareness of Laos’ rich diversity of medicinal plants and will hopefully provide incentive to preserve the undeveloped forested areas that remain, which still hold a wealth of medical information for future discoveries.

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Ethnobotanical approach versus random approach in the search for new bioactive compounds: Support of a hypothesis

Cited by 48 publications

References 26 publications

Prospecting for Bioactive Constituents from Traditional Medicinal Plants through Ethnobotanical Approaches

Prospecting for Bioactive Constituents from Traditional Medicinal Plants through Ethnobotanical Approaches

Traditional medicines and globalization: current and future perspectives in ethnopharmacology

New finding of an anti-TB compound in the genus Marsypopetalum (Annonaceae) from a traditional herbal remedy of Laos

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