Biochemical Pharmacology volume 78, issue 6, P648-655 2009 DOI: 10.1016/j.bcp.2009.05.012 View full text
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David J. Fernandez, Benita L. McVicker, Dean J. Tuma, Pamela L. Tuma

Abstract: AbstractAlthough alcoholic liver disease is clinically well-described, the molecular basis for alcohol-induced hepatotoxicity is not well understood. Previously, we determined that the clathrin-mediated internalization of asialoglycoprotein receptor was impaired in ethanol-treated WIF-B cells whereas the internalization of a glycophosphatidylinositol-anchored protein thought to be endocytosed via a caveolae/raft-mediated pathway was not changed suggesting that clathrin-mediated endocytosis is selectively impa…

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