Estudo morfológico e morfométrico da próstata de cobaios (Cavia porcellus, Linnaeus, 1758) durante o desenvolvimento pós-natal

Abstract

ResumoA próstata é muito importante clinicamente, pois desempenha um papel importante na produção de sêmen e fertilização do óvulo, além de ser frequentemente acometida por doenças como a hiperplasia prostática e o câncer de próstata. O objetivo deste estudo foi avaliar a morfologia, morfometria, índice organossomático (IOS), espessura da parede e altura do epitélio da próstata de cobaios em diferentes fases do desenvolvimento pós-natal. A partir dos resultados, concluiu-se que a próstata de cobaios assemelha-se a de Chinchilla laniger quanto às unidades túbulo-alveolares; a da paca; cutia e capivara quanto à presença de pregas altas ramificadas na mucosa e a de humanos quanto ao epitélio secretor do tipo cúbico simples. As principais alterações observadas durante o desenvolvimento pós-natal foram o aumento significativo do estroma muscular e da altura do epitélio secretor a partir da pré-puberdade tardia até a pós-puberdade 1 e depois diminuição na pós-puberdade 2, significativa apenas para o estroma muscular. Estes resultados fundamentam estudos futuros sobre o desenvolvimento pós-natal e de envelhecimento prostático e fundamentam o uso de cobaios como modelo experimental para pesquisas a respeito do complexo prostático.

The Effect of Kuchala (Arum Korolkowii Regel, 1873) Tuber Tincture to Increase of the Serum Testosterone in the Adult Male Guinea Pigs (Cavia Porcellus Linnaeus, 1758)

“…To determine this, we analyzed the literature and found that among the different laboratory animals, the guinea pig has many morphofunctional similarities with humans, in terms of the lung physiology [20], and hormonal, immunological and corticosteroid responses [11,12]. Importantly, the guinea pig has many common features with humans in terms of reproduction related to the accessory glands [14,15], the characteristics of the placenta [21], and morphological and functional analysis of spermatogenesis [22]. In addition, information exits that the testosterone and androstenedione content in serum and testes were different in guinea pigs in the prenatal [18,23], and postnatal [24] periods.…”

“…Guinea pigs have been comprehensively studied as laboratory animals using biological, morphological and physiological approaches. Its size and lifestyle make the guinea pig easy to keep and to conduct experimental studies on and, importantly, it has many of the same morphological and physiological characteristics as humans [11,12], including in terms of reproduction [13][14][15][16][17][18]. Consequently, guinea pigs are frequently used as a biological model in studies of a number of infectious bacterial and noninfectious diseases [12,19].…”

The Effect of Kuchala (Arum Korolkowii Regel, 1873) Tuber Tincture to Increase of the Serum Testosterone in the Adult Male Guinea Pigs (Cavia Porcellus Linnaeus, 1758)

“…For this purpose, we analyzed the literature data and found that among different laboratory animal's guinea pig has many morphofunctional similarities with human, namely by the lung physiology [24], hormonal, immunological and corticosteroid responses [13,14]. Importantly, the guinea pig has many common features with human reproduction -by presenting of the accessory glands [16,17], characteristics of the placenta [25], morphological and functional analysis of spermatogenesis [26]. Besides, it has available information that the content of testosterone and androstenedione in serum and testis were different in guinea pigs in the prenatal [20,27], and postnatal [28] periods.…”

“…Guinea pig was comprehensive studied as laboratory animal in biological, morphological and physiological approaches. Its size and lifestyle make the guinea pig easy to keep and conducts experimental study, and importantly, it has many same morphological and physiological characteristics with human [13,14], including in reproduction [15,16,17,18,19,20].…”

Participation of the Intercostal Nerves to the Innervation of the Diaphragm Muscle in Cavia porcellus

“…It is frequently used for studies on the anatomy and physiology that shall be applied to the humans and other species. [21][22][23] Even with the diaphragm being responsible for such an essential function as breathing, there are no studies on the role of the intercostal nerves to its innervation in guinea pigs.…”