ESTUDO ELETRÔNICO DA REATIVIDADE DA 8-Hidroxiquinolina SUBSTITUÍDA FRENTE AO SÍTIO DE LIGAÇÃO DO PEPTÍDEO Β-Amiloide AO ÍON ZINCO

Silva, Talis Uelisson da; Machado, Sérgio de Paula

doi:10.21577/0100-4042.20170411

Cited by 3 publications

(1 citation statement)

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“…Apesar de positivos, os resultados dos ensaios clínicos e pré-clínicos indicaram que deveria ser feita mais investigação, nomeadamente orientada para o design de derivados multifuncionais. Exemplos desta estratégia são a intensa investigação em derivados de HQ [51][52][53][54], em particular os derivados da ligação/ fusão desta unidade molecular com fármacos anti-AD ou com os seus princípios farmacológicos, como a TAC ou o DNP, resultando em compostos híbridos com capacidade de inibição da enzima AChE, uma importante propriedade desses fármacos [56,57].…”

Section: Agentes Quelantes Com Coordenação (No)unclassified

Controlo de Biometais no Contexto de Fármacos Multifuncionais para a Doença de Alzheimer

M. Amelia Santos,

Sílvia Chaves

2024

BSPQuimica

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Section: Agentes Quelantes Com Coordenação (No)unclassified

Controlo de Biometais no Contexto de Fármacos Multifuncionais para a Doença de Alzheimer

M. Amelia Santos,

Sílvia Chaves

2024

BSPQuimica

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Electronic investigation of the effect of substituents on the SOD mimic activity of copper (II) complexes with 8-hydroxyquinoline-derived ligands

Silva

Pougy

Silva

et al. 2021

Journal of Inorganic Biochemistry

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Role of Metal Cations of Copper, Iron, and Aluminum and Multifunctional Ligands in Alzheimer’s Disease: Experimental and Computational Insights

et al. 2023

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Alzheimer’s disease (AD) is the most common form of dementia, affecting millions of people around the world. Even though the causes of AD are not completely understood due to its multifactorial nature, some neuropathological hallmarks of its development have been related to the high concentration of some metal cations. These roles include the participation of these metal cations in the production of reactive oxygen species, which have been involved in neuronal damage. In order to avoid the increment in the oxidative stress, multifunctional ligands used to coordinate these metal cations have been proposed as a possible treatment to AD. In this review, we present the recent advances in experimental and computational works aiming to understand the role of two redox active and essential transition-metal cations (Cu and Fe) and one nonbiological metal (Al) and the recent proposals on the development of multifunctional ligands to stop or revert the damaging effects promoted by these metal cations.

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ESTUDO ELETRÔNICO DA REATIVIDADE DA 8-Hidroxiquinolina SUBSTITUÍDA FRENTE AO SÍTIO DE LIGAÇÃO DO PEPTÍDEO Β-Amiloide AO ÍON ZINCO

Cited by 3 publications

References 0 publications

Controlo de Biometais no Contexto de Fármacos Multifuncionais para a Doença de Alzheimer

Controlo de Biometais no Contexto de Fármacos Multifuncionais para a Doença de Alzheimer

Electronic investigation of the effect of substituents on the SOD mimic activity of copper (II) complexes with 8-hydroxyquinoline-derived ligands

Role of Metal Cations of Copper, Iron, and Aluminum and Multifunctional Ligands in Alzheimer’s Disease: Experimental and Computational Insights

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