Estudo descritivo da freqüência de micobactérias não tuberculosas na Baixada Santista (SP)

Zamarioli, Liliana Aparecida; Coelho, Andréa Gobetti Vieira; Pereira, Clemira Martins; Nascimento, Ana Carolina Chiou; Ueki, Suely Yoko Mizuka; Chimara, Érica

doi:10.1590/s1806-37132008000800008

Cited by 19 publications

(11 citation statements)

References 12 publications

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“…RGM species, including M. abscessus , M. massiliense , M. bolletii (formally M. abscessus species) represented almost 45% of all NTM pulmonary cases, whereas in Sao Paulo, M. avium complex (MAC) and M. kansasii represent the most common NTM in pulmonary disease [51], [52]. In addition, when stratifying to the NTM species level, we observed that gender associated infection was even more pronounced in the case of M. chelonae-M. abscessus complex (∼45% females), especially M. massiliense (34.5%).…”

Section: Discussionmentioning

confidence: 99%

Occurrence of Nontuberculous Mycobacterial Pulmonary Infection in an Endemic Area of Tuberculosis

et al. 2013

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The majority of investigations of the epidemiology of nontuberculous mycobacteria (NTM) have focused on highly developed nations with a low prevalence of tuberculosis. In contrast, the Para state of north Brazil represents an area of high tuberculosis prevalence and increasing NTM incidence. Toward the goal of understanding the dynamics of infection by all Mycobacterium species, we report patient characteristics and the identification of NTM strains isolated from sputum samples from patients that were residents of Para, a state in the Amazon region, Northern of Brazil, over the period January 2010 through December 2011 (2 years). The 29 NTM patients comprised 13.5% of positive mycobacterial cultures over the 2-year period. A major risk factor for NTM pulmonary disease was previous tuberculosis (76%). Further, the average age of NTM patients (52 years) was significantly higher than that of tuberculosis patients (39 years) and more were female (72.4% vs. 37.4%). Unlike other Brazilian states, NTM pulmonary patients in Para were infected with a different spectrum of mycobacteria; primarily the rapidly growing Mycobacterium massiliense and Mycobacterium simiae complex.

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Section: Discussionmentioning

confidence: 99%

Occurrence of Nontuberculous Mycobacterial Pulmonary Infection in an Endemic Area of Tuberculosis

et al. 2013

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“…However, the species isolated from the Ugandan ecosystems have been found to cause disease in patients in other parts of the world. For example bacteria in the M. avium complex are known to cause opportunistic infections in animals and humans [2], and have been isolated from cattle and humans with tuberculous lesions in Uganda [20,21], Zambia and other parts of the world [39,40]. M. simiae has been isolated from two Ugandan HIV infected patients [41].…”

Section: Discussionmentioning

confidence: 99%

“…M. simiae has been isolated from two Ugandan HIV infected patients [41]. The other NTM detected in this study have been isolated from patients in different parts of the world, and may cause clinical syndromes: chronic bronchopulmonary disease, lymphadenitis, skin and soft tissue disease, skeletal disease, and disseminated and catheter-related infections [39,40,42-46]. In humans, immunocompromised individuals such as the malnourished, HIV/AIDS infected, children or the elderly are often affected [47].…”

Section: Discussionmentioning

confidence: 99%

Isolation of non-tuberculous mycobacteria from pastoral ecosystems of Uganda: Public Health significance

et al. 2011

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BackgroundThe importance of non-tuberculous mycobacteria (NTM) infections in humans and animals in sub-Saharan Africa at the human-environment-livestock-wildlife interface has recently received increased attention. NTM are environmental opportunistic pathogens of humans and animals. Recent studies in pastoral ecosystems of Uganda detected NTM in humans with cervical lymphadenitis and cattle with lesions compatible with bovine tuberculosis. However, little is known about the source of these mycobacteria in Uganda. The aim of this study was to isolate and identify NTM in the environment of pastoral communities in Uganda, as well as assess the potential risk factors and the public health significance of NTM in these ecosystems.MethodA total of 310 samples (soil, water and faecal from cattle and pigs) were examined for mycobacteria. Isolates were identified by the INNO-Lipa test and by 16S rDNA sequencing. Additionally, a questionnaire survey involving 231 pastoralists was conducted during sample collection. Data were analysed using descriptive statistics followed by a multivariable logistic regression analysis.ResultsForty-eight isolates of NTM were detected; 25.3% of soil samples, 11.8% of water and 9.1% from animal faecal samples contained mycobacteria. Soils around water sources were the most contaminated with NTM (29.8%). Of these samples, M. fortuitum-peregrinum complex, M. avium complex, M. gordonae, and M. nonchromogenicum were the most frequently detected mycobacteria. Drinking untreated compared to treated water (OR = 33), use of valley dam versus stream water for drinking and other domestic use (OR = 20), sharing of water sources with wild primates compared to antelopes (OR = 4.6), sharing of water sources with domestic animals (OR = 5.3), and close contact with cattle or other domestic animals (OR = 13.8) were the most plausible risk factors for humans to come in contact with NTM in the environment.ConclusionsThe study detected a wide range of potentially pathogenic NTM from the environment around the pastoral communities in Uganda. Drinking untreated water and living in close contact with cattle or other domestic animals may be risk factors associated with the possibility of humans and animals acquiring NTM infections from these ecosystems.

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“…Non-tuberculous mycobacteria were also sent to the Central Reference Lab for species identification by a phenotypic technique and molecular typing (PCR coupled to the Restriction Fragment Length Polymorphism - RFLP, and the analysis of a 441 bp fragment from the hsp65 gene (PRA-hsp65) 18 . …”

Section: Methodsmentioning

confidence: 99%

A Decade Trend of Multidrug Resistant Tuberculosis in São Paulo State, Brazil

Bollela

Puga

Moya

et al. 2016

Rev. Inst. Med. trop. S. Paulo

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SUMMARYThe aim of this retrospective study was to review all the notified cases of multidrug-resistant tuberculosis (MDR-TB) in São Paulo State (Brazil), as well as to describe and discuss the clinical, microbiological and radiologic aspects in a single reference center, within the same state, from 2000 to 2012. There were 1,097 notifications of MDR-TB in São Paulo State over this period, 70% affecting men aged on average 38 years (10-77). There was a significant fall in the MDR-TB mortality rate from 30% to 8% (2000-2003 versus 2009-2012). The same trend was observed in the cases studied at the reference center. The number of notified cases increased and death rate reduced from 37.5% (2000-2005) to 3.4% (2006-2012). Among the 48 drug-resistant TB cases, 17 non-tuberculous Mycobacteria were isolated in the sputum culture of nine patients, without any clinical significance. TB and fungus co-infection was diagnosed in 15% (7/48) of these cases: three with confirmed chronic pulmonary aspergillosis and four with positive serological markers for paracoccidioidomycosis. Overall, the reports show that MDR-TB diagnosis and cure rates have increased, while the mortality rate has decreased significantly in São Paulo State including in the studied reference center.

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Estudo descritivo da freqüência de micobactérias não tuberculosas na Baixada Santista (SP)

Cited by 19 publications

References 12 publications

Occurrence of Nontuberculous Mycobacterial Pulmonary Infection in an Endemic Area of Tuberculosis

Occurrence of Nontuberculous Mycobacterial Pulmonary Infection in an Endemic Area of Tuberculosis

Isolation of non-tuberculous mycobacteria from pastoral ecosystems of Uganda: Public Health significance

A Decade Trend of Multidrug Resistant Tuberculosis in São Paulo State, Brazil

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