Estudo comparativo entre MBI (FICE®) e a magnificação com índigo-carmin no diagnóstico diferencial de lesões neoplásicas e não-neoplásicas de cólon e reto

Santos, Carlos Eduardo Oliveira dos; Pereira-Lima, Júlio Carlos; Lopes, César Vivian; Malaman, Daniele; Parada, Artur Adolfo; Salomão, Antônio David

doi:10.1590/s0004-28032009000200007

Cited by 12 publications

(8 citation statements)

References 21 publications

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“…CE with indigo carmine and magnification is used to evaluate pit patterns and has shown good results in discriminating between neoplastic and non-neoplastic lesions, with accuracy ranging from 84 to 96.8%, sensitivity from 91.4–97.6%, and specificity from 67.2–93.9% [9–12]. However, real-time CE is a relatively laborious, time-consuming process, and its learning curve for interpreting pit patterns is considered slow.…”

Section: Discussionmentioning

confidence: 99%

“…As in our previous studies [12, 38], we performed DCE or real-time CE only after detection of lesions under high-definition white-light examination.…”

Section: Discussionmentioning

confidence: 99%

“…The Kudo classification was not designed to be used with DCE though some papers [12, 38, 40] have already shown that it could be employed for evaluation of the pit pattern, as well as the the capillary pattern with good results. East et al [40] detected a very good agreement between both methods (kappa = 0.83), and, besides, the combination of both methods for evaluation of the pit and capillary patterns increased the sensitivity ( P = 0.06) once compared to the single analysis of the pit pattern, although with a minimal difference ( P = 0.50) when compared to the analysis of the capillary pattern.…”

Section: Discussionmentioning

confidence: 99%

“…Colonoscopy is the best diagnostic method, and the use of chromoendoscopy (CE) with indigo carmine and crystal violet may help characterize the morphology of lesions, whose correct interpretation is crucial in choosing the appropriate treatment. When associated with magnification, this method can provide high accuracy in differentiating neoplastic from non-neoplastic lesions after pit pattern analysis [7–12], in the assessment of invasion depth of carcinomas [13], and in the diagnosis of diminutive residual tumor after endoscopic resection [14], thus increasing the efficiency of the endoscopic procedure [15]. Some studies indicate that CE may increase the detection rate of small flat adenomas in diagnostic colonoscopies [16, 17].…”

Section: Introductionmentioning

confidence: 99%

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Digital Chromoendoscopy for Diagnosis of Diminutive Colorectal Lesions

Santos

Malaman

Lopes

et al. 2012

Diagnostic and Therapeutic Endoscopy

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Introduction. To compare the accuracy of digital and real-time chromoendoscopy for the differential diagnosis of diminutive (<5 mm) neoplastic and nonneoplastic colorectal lesions. Materials and Methods. This is a prospective randomized study comparing the Fujinon intelligent color enhancement (FICE) system (65 patients/95 lesions) and indigo carmine (69 patients/120 lesions) in the analysis of capillary meshwork and pit pattern, respectively. All lesions were less than 5 mm in diameter, and magnification was used in both groups. Histopathology was the gold standard examination. Results. Of 215 colorectal lesions, 153 (71.2%) were adenomas, and 62 were hyperplastic polyps (28.8%). Morphological analysis revealed 132 (61.4%) superficial lesions, with 7 (3.3%) depressed lesions, and 83 (38.6%) protruding lesions. Vascular meshwork analysis using FICE and magnification resulted in 91.7% sensitivity, 95.7% specificity, and 92.6% accuracy in differentiating neoplastic from nonneoplastic lesions. Pit pattern analysis with indigo carmine and magnification showed 96.5% sensitivity, 88.2% specificity, and 94.2% accuracy for the same purpose. Conclusion. Both magnifying virtual chromoendoscopy and indigo carmine chromoendoscopy showed high accuracy in the histopathological diagnosis of colorectal lesions less than 5 mm in diameter.

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Section: Discussionmentioning

confidence: 99%

“…As in our previous studies [12, 38], we performed DCE or real-time CE only after detection of lesions under high-definition white-light examination.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Digital Chromoendoscopy for Diagnosis of Diminutive Colorectal Lesions

Santos

Malaman

Lopes

et al. 2012

Diagnostic and Therapeutic Endoscopy

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“…The analysis of the capillary pattern by magnification colonoscopy with digital chromoscopy has yielded excellent results in the differential diagnosis of neoplastic and non-neoplastic colorectal lesions, with good to excellent intra- and interobserver agreement 42-45. We also hypothesized that the abolishment of colonic contractility would allow a better evaluation of these lesions by digital chromoendoscopy with magnification.…”

Section: Discussionmentioning

confidence: 99%

Hyoscine butylbromide for colorectal polyp detection: prospective, randomized, placebo-controlled trial

Santos¹,

Moreira²,

Pereira-Lima³

et al. 2017

Clinics

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OBJECTIVES:The removal of pre-malignant colorectal lesions prevents cancer. Hyoscine has been proposed as a means of improving diagnosis by reducing colonic movements. The aim of this study was to analyze whether this anti-spasmodic enhances the detection of pre-malignant colorectal lesions.METHODS:In a randomized, double-blinded fashion patients received hyoscine or a saline solution in all consecutive colonoscopies in which the cecum was reached. Lesions were analysed with respect to number, size, location, histology and capillary pattern.RESULTS:A total of 440 colonoscopies were randomized. The overall polyp detection rate (PDR) and the adenoma detection rate (ADR) were 65.2% and 49.3%, respectively. In the hyoscine group, non-polypoid lesions were detected significantly more often (p=0.01). In the placebo group 281 lesions were diagnosed (202 adenomas) and in the hyoscine group 282 lesions were detected (189 adenomas) (p=0.23). The PDR and ADR were similar between the placebo and hyoscine groups (64% vs 66% and 50% vs 47%, respectively). No differences were observed between the two groups in the advanced-ADR or advanced neoplasia detection rate, as well the mean numbers of polyps, adenomas, advanced adenomas and advanced neoplasias detected per patient. The administration of hyoscine also did not improve the diagnostic accuracy of digital chromoendoscopy. The presence of adenomatous polyps in the right colon was detected significantly more frequently in the hyoscine group (OR 5.41 95% CI 2.7 - 11; p<0.01 vs OR 2.3 95% CI 1.1 - 4.6; p=0.02).CONCLUSION:The use of hyoscine before beginning the withdrawal of the colonoscope does not seem to enhance the PDR and the ADR.

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Chromoendoscopy in gastroenterology

Shehab

2010

Arab Journal of Gastroenterology

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Estudo comparativo entre MBI (FICE®) e a magnificação com índigo-carmin no diagnóstico diferencial de lesões neoplásicas e não-neoplásicas de cólon e reto

Cited by 12 publications

References 21 publications

Digital Chromoendoscopy for Diagnosis of Diminutive Colorectal Lesions

Digital Chromoendoscopy for Diagnosis of Diminutive Colorectal Lesions

Hyoscine butylbromide for colorectal polyp detection: prospective, randomized, placebo-controlled trial

Chromoendoscopy in gastroenterology

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