Abstract:SUMMARYThe present study was carried out to investigate differences in the immuno¬ antigenicity of 8 P. brasiliensis isolates from 3 endemic areas (Botucatu: Pb
“…Of note is a previous report demonstrating that variations in the pattern of NET release occur when induced by distinct P brasiliensis strains 65 ; in addition, differences in antigenicity have been associated with distinct isolates of P brasiliensis . 66–68 Therefore these observations could explain the apparent opposite results.…”
Our data suggest a nonredundant role of CD40L-CD40 interaction in neutrophil development and function that could be improved in vitro by rhIFN-γ, indicating a potential novel therapeutic application for this cytokine.
“…Of note is a previous report demonstrating that variations in the pattern of NET release occur when induced by distinct P brasiliensis strains 65 ; in addition, differences in antigenicity have been associated with distinct isolates of P brasiliensis . 66–68 Therefore these observations could explain the apparent opposite results.…”
Our data suggest a nonredundant role of CD40L-CD40 interaction in neutrophil development and function that could be improved in vitro by rhIFN-γ, indicating a potential novel therapeutic application for this cytokine.
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