2017
DOI: 10.1002/jcp.26233
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Abstract: Decline of pluripotency in bone marrow stromal cells (BMSCs) associated with estrogen deficiency leads to a bone formation defect in osteoporosis. Special AT-rich sequence binding protein 2 (SATB2) is crucial for maintaining stemness and osteogenic differentiation of BMSCs. However, whether SATB2 is involved in estrogen-deficiency associated-osteoporosis is largely unknown. In this study, we found that estrogen mediated pluripotency and senescence of BMSCs, primarily through estrogen receptor beta (ERβ). BMSCs… Show more

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Cited by 50 publications
(25 citation statements)
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“…It has been reported that cell proliferation and osteogenic differentiation of BMSCs are associated with osteoporosis [7]. Additionally, studies in postmenopausal osteoporosis indicated that estrogen influenced cellular process of BMSCs [8]. These findings implied a vital role of BMSCs in the development of postmenopausal osteoporosis.…”
Section: Introductionmentioning
confidence: 87%
“…It has been reported that cell proliferation and osteogenic differentiation of BMSCs are associated with osteoporosis [7]. Additionally, studies in postmenopausal osteoporosis indicated that estrogen influenced cellular process of BMSCs [8]. These findings implied a vital role of BMSCs in the development of postmenopausal osteoporosis.…”
Section: Introductionmentioning
confidence: 87%
“…To study the role of Ash1l in MSCs regulation, we start with exploring whether it participates in bone loss diseases and the relationship between bone mass and Ash1l as well as H3K4me3. We used animal models of aging and OVX to induce age-related osteoporosis and estrogen deficiency-mediated postmenopausal osteoporosis respectively, both of which have been widely used to mimic the molecular pathogenesis of osteoporotic bone loss [27][28][29]. We compared the bone mass of femurs in 2-and 24-months-old mice with micro-CT analysis.…”
Section: The Expression Of Ash1l In Bone Was Positively Correlated Wimentioning
confidence: 99%
“…They play a vital role in bone formation during the process of bone remodeling in which the cell differentiates into osteoblasts to produce collagen type 1 and matrix proteins, such as osteocalcin and osteopontin, and hydroxyapatite is then deposited onto the protein matrix to form the mineralized bone structure . Thus, medical conditions that impair BMSC activities or functions for bone formation often interrupt normal bone remodeling, causing bone loss . In T1DM patients, bone loss can occur when osteoblastogenesis of BMSCs and osteoblast activity are hindered and/or osteoclast activity is promoted .…”
Section: Introductionmentioning
confidence: 99%