Estrogen receptor β promotes the vasculogenic mimicry (VM) and cell invasion via altering the lncRNA-MALAT1/miR-145-5p/NEDD9 signals in lung cancer

Yu, Wei; Ding, Jie; He, Maio; Chen, Yuan; Wang, Ronghao; Han, Zhenwei; Xing, Emily Zixin; Zhang, Cuntai; Yeh, Shuyuan

doi:10.1038/s41388-018-0463-1

Cited by 98 publications

(131 citation statements)

References 63 publications

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“…[26][27][28][29] In this study, we not only found that MALAT1 expression was apparently upregulated in HCC tissues and HCC cell lines, but also observed that MALAT1 was inversely correlated with prognosis of HCC patients. High MALAT1 expression has been frequently observed in various cancers, such as lung cancer, renal cancer, colorectal cancer, HCC, etc.…”

supporting

confidence: 55%

“…High MALAT1 expression has been frequently observed in various cancers, such as lung cancer, renal cancer, colorectal cancer, HCC, etc. [26][27][28][29] In this study, we not only found that MALAT1 expression was apparently upregulated in HCC tissues and HCC cell lines, but also observed that MALAT1 was inversely correlated with prognosis of HCC patients. A higher MALAT1 level meant worse OS and RFS of HCC patients.…”

supporting

confidence: 55%

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MicroRNA‐3064‐5p sponged by MALAT1 suppresses angiogenesis in human hepatocellular carcinoma by targeting the FOXA1/CD24/Src pathway

Zhang¹,

et al. 2019

FASEB j.

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Abbreviations: CLSM, confocal laser scanning microscopy; Co-IP, co-immunoprecipitation; FISH, fluorescence in situ hybridization; FOXA1, forkhead box protein A1; HCC, hepatocellular carcinoma; MALAT1, metastasis-associated lung adenocarcinoma transcript 1; MMP12, macrophage metalloelastase; MVD, microvessel density; OS, overall survival; RFS, recurrence-free survival; RIP, RNA binding protein immunoprecipitation; TNM, tumor node metastasis; VEGFA, vascular endothelial growth factor A. AbstractAngiogenesis is critical for the development, progression, and metastasis of hepatocellular carcinoma (HCC), but the roles of miR-3064-5p in HCC angiogenesis are still unknown. In this study, the roles of miR-3064-5p in HCC angiogenesis were studied in 192 HCC patients, xenograft mouse models, and HCC cell lines. The results showed that miR-3064-5p expression was significantly decreased in HCC tissues and cells, and downregulated miR-3064-5p was associated with upregulated angiogenic potential of HCC. MiR-3064-5p inhibited proangiogenic VEGFA and angiogenin expressions but induced antiangiogenic endostatin and MMP12 expressions, finally leading to suppression of HCC angiogenesis, as shown by the decline in intratumoral microvessel density (MVD). Moreover, miR-3064-5p was inversely correlated with lncRNA MALAT1 and FOXA1. FOXA1 bound to and interacted with CD24 and then regulated Src phosphorylation. MiR-3064-5p played an antiangiogenic role by inhibiting the FOXA1/CD24/Src pathway, whereas oncogenic MALAT1 functioned as a competing endogenous RNA (ceRNA) by sponging miR-3064-5p to alleviate the suppressive effect on the FOXA1 pathway. HCC patients with high miR-3064-5p, low MALAT1, or low FOXA1 expression had a better prognosis with longer overall survival and recurrence-free survival. In univariate and multivariate analyses, miR-3064-5p was identified as the independent prognostic predicator for HCC progression and patient survival. Taken together, miR-3064-5p exerts an antiangiogenic role by targeting the FOXA1/CD24/Src pathway but oncogenic lncRNA MALAT1 acts as a ceRNA to sponge miR-3064-5p. MiR-3064-5p is of great clinical significance and is a novel prognostic indicator and an attractive therapeutic target for HCC. K E Y W O R D SceRNA, FOXA1/CD24/Src pathway, HCC angiogenesis, lncRNA MALAT1, miR-3064-5p | 67 ZHANG et Al.

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supporting

confidence: 55%

supporting

confidence: 55%

MicroRNA‐3064‐5p sponged by MALAT1 suppresses angiogenesis in human hepatocellular carcinoma by targeting the FOXA1/CD24/Src pathway

Zhang¹,

et al. 2019

FASEB j.

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“…In the past, it was thought that macrophages could directly kill tumor cells or induce the immune response during the anti-tumor immunomodulation process. Recently, some studies have shown that tumor-associated macrophages do not play an anti-tumor role, but promote tumorigenesis, growth, invasion, migration, and VM formation [69][70][71]. In 2016, Barnett et al reported that macrophages play a supportive role in the process of the formation of a primitive tubular network in tumors and Matrigel.…”

Section: Tumor-associated Macrophagesmentioning

confidence: 99%

“…Rong et al showed that M2 macrophages could promote VM formation via the PGE2/EP1/PKC pathway in glioblastoma multiforme (GBM) in a COX-2 dependent manner [72]. In 2017, Zhang et al reported M2-like macrophages promoted VM formation by amplifying IL-6 secretion via the PKC pathway in vitro studies of glioma cell lines [70].…”

Section: Tumor-associated Macrophagesmentioning

confidence: 99%

Vasculogenic mimicry in carcinogenesis and clinical applications

et al. 2020

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Distinct from classical tumor angiogenesis, vasculogenic mimicry (VM) provides a blood supply for tumor cells independent of endothelial cells. VM has two distinct types, namely tubular type and patterned matrix type. VM is associated with high tumor grade, tumor progression, invasion, metastasis, and poor prognosis in patients with malignant tumors. Herein, we discuss the recent studies on the role of VM in tumor progression and the diverse mechanisms and signaling pathways that regulate VM in tumors. Furthermore, we also summarize the latest findings of non-coding RNAs, such as lncRNAs and miRNAs in VM formation. In addition, we review application of molecular imaging technologies in detection of VM in malignant tumors. Increasing evidence suggests that VM is significantly associated with poor overall survival in patients with malignant tumors and could be a potential therapeutic target.

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“…120 According to our review, the molecular mechanism of LncRNAs regulating NSCLC metastasis mainly includes three aspects as to one LncRNA, the molecular mechanism may contain many aspects. For example, LncRNA-MALAT1, which is highly conserved among mammals, could not only competitively bind with miR-145-5p, 121 miR-204 122 and miR-206 123 as a ceRNA, but also activate Akt/mTOR signalling pathway in order to induce the metastasis of NSCLC. 123 The same LncRNA may have different molecular mechanism in diverse tumours.…”

Section: Influence the Properties Of Cancer Stem Cell (Csc)mentioning

confidence: 99%

Long non‐coding RNAs: How to regulate the metastasis of non–small‐cell lung cancer

Fang

Wang

Gong

et al. 2020

J Cellular Molecular Medi

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Non–small‐cell lung cancer (NSCLC) has become the most lethal human cancer because of the high rate of metastasis. Hence, clarifying the molecular mechanism underlying NSCLC metastasis is very important to improve the prognosis of patients with NSCLC. Long non‐coding RNAs (LncRNAs) are a class of RNA molecules longer than 200 nucleotides, which can participate in diverse biological processes. About 18% of human LncRNAs were recently found to be associated with tumours. Many studies indicated that aberrant expression of LncRNAs played key roles in the progression and metastasis of NSCLC. According to the function in tumours, LncRNAs can be divided into two classes: oncogenic LncRNAs and tumour‐suppressor LncRNAs. In this review, we summarized the main molecular mechanism of LncRNAs regulating NSCLC metastasis, including three aspects: (a) LncRNAs interact with miRNAs as ceRNAs; (b) LncRNAs bind with target proteins; and (c) LncRNAs participate in the transduction of different signal pathways. Then, LncRNAs can exert their function to regulate the metastasis of NSCLC through influencing the progression of epithelial‐mesenchymal transition (EMT) and the properties of cancer stem cell (CSC). But, it is necessary to do some further research to demonstrate the LncRNAs particular regulatory mechanism of inhibiting the metastasis of NSCLC and explore new drugs targeting LncRNAs.

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Estrogen receptor β promotes the vasculogenic mimicry (VM) and cell invasion via altering the lncRNA-MALAT1/miR-145-5p/NEDD9 signals in lung cancer

Cited by 98 publications

References 63 publications

MicroRNA‐3064‐5p sponged by MALAT1 suppresses angiogenesis in human hepatocellular carcinoma by targeting the FOXA1/CD24/Src pathway

MicroRNA‐3064‐5p sponged by MALAT1 suppresses angiogenesis in human hepatocellular carcinoma by targeting the FOXA1/CD24/Src pathway

Vasculogenic mimicry in carcinogenesis and clinical applications

Long non‐coding RNAs: How to regulate the metastasis of non–small‐cell lung cancer

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