Abstract:Glioblastoma is a deadly and common primary brain tumor. Poor prognosis is linked to high proliferation and cell heterogeneity. Sex differences may play a role in patient outcome. Previous studies showed that ER-α36, a variant of the estrogen receptor, mediated non-genomic estrogen signaling and is highly expressed in many ER-negative tumors. ER-α36 also associates with the EGFR. We showed that ER-α36 was highly expressed and confirmed that ER-α36 co-labels with EGFR in glioma specimens. We also investigated t… Show more
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