Estrogen production and metabolism in normal postmenopausal women and postmenopausal women with breast or endometrial cancer

Alterations in the production rate and the metabolism of oestrone and oestrone sulphate in breast cancer patients treated with aminoglutethimide

“…The clearance and production rates for oestrone in our patients were in the lower range. but consistent with results reported previously for breast cancer patients and normal postmenopausal women (Judd et al, 1982;Kirschner et al, 1978;Longcope & Williams, 1974;Reed et al, 1986). The plasma clearance of oestrone sulphate was similar to values found by us in a previous investigation (L0nm 'ng et al, 1987), the oestrone sulphate production rate was found somewhat lower than values reported for young men and menstruating women in the follicular phase of cyclus (Longcope, 1972;Ruder et al, 1972 (Noel et al, 1979).…”

“…However, in recent years the hypothesis that post-menopausal oestrogen production does occur by peripheral aromatisation of androstenedione only has been challenged (Kirschner et al, 1978: Longcope et al, 1982Reed et al, 1986). Our results indirectly support a theory that oestrogen production pathways other than the aromatisation of androstenedione into oestrone may be intact in patients receiving aminoglutethimide treatment.…”

Alterations in the production rate and the metabolism of oestrone and oestrone sulphate in breast cancer patients treated with aminoglutethimide

“…The clearance and production rates for oestrone in our patients were in the lower range. but consistent with results reported previously for breast cancer patients and normal postmenopausal women (Judd et al, 1982;Kirschner et al, 1978;Longcope & Williams, 1974;Reed et al, 1986). The plasma clearance of oestrone sulphate was similar to values found by us in a previous investigation (L0nm 'ng et al, 1987), the oestrone sulphate production rate was found somewhat lower than values reported for young men and menstruating women in the follicular phase of cyclus (Longcope, 1972;Ruder et al, 1972 (Noel et al, 1979).…”

“…However, in recent years the hypothesis that post-menopausal oestrogen production does occur by peripheral aromatisation of androstenedione only has been challenged (Kirschner et al, 1978: Longcope et al, 1982Reed et al, 1986). Our results indirectly support a theory that oestrogen production pathways other than the aromatisation of androstenedione into oestrone may be intact in patients receiving aminoglutethimide treatment.…”

Influence of the Maturity of the Vaginal Epithelium upon the Absorption of Vaginally Administered Estradiol-17β and Progesterone in Postmenopausal Women

“…A sim ilar association between vaginal hormone cytology and serum 'total' estrogens, i.e., E[ + E2, in postmenopausal women has previously been shown by Benjamin and Deutsch [3]. These findings further confirm the superior ity of E| or E| + E2 assay compared to E2 when studying the estrogen status in subjects with mainly extragonadal estrogen sources, i.e., postmenopausal women and men [7,8],…”

Treatment of urogenital atrophy with low-dose estradiol: preliminary results

“…Previously published studies report an average metabolic clearance rate for E 2 in postmenpausal women of approximately 1,000 L/24 h. 37 Based on an average increment of E 2 of 2 pg/mL during a period of 4 h after each application, our calculations indicate that 0.33 µg …”

“…No comprehensive data are available on responses of urethral mucosa, although the slight increases in superficial cells observed in this study are within the ranges expected. 37 No systematic endometrial biopsy data have been obtained to compare acute versus chronic absorption of estrogen. 33,[39][40][41][42] In general, progesterone withdrawal challenge has been used as a noninvasive means to detect endometrial stimulation.…”

Alterations in the production rate and the metabolism of oestrone and oestrone sulphate in breast cancer patients treated with aminoglutethimide

“…The clearance and production rates for oestrone in our patients were in the lower range. but consistent with results reported previously for breast cancer patients and normal postmenopausal women (Judd et al, 1982;Kirschner et al, 1978;Longcope & Williams, 1974;Reed et al, 1986). The plasma clearance of oestrone sulphate was similar to values found by us in a previous investigation (L0nm 'ng et al, 1987), the oestrone sulphate production rate was found somewhat lower than values reported for young men and menstruating women in the follicular phase of cyclus (Longcope, 1972;Ruder et al, 1972 (Noel et al, 1979).…”

“…However, in recent years the hypothesis that post-menopausal oestrogen production does occur by peripheral aromatisation of androstenedione only has been challenged (Kirschner et al, 1978: Longcope et al, 1982Reed et al, 1986). Our results indirectly support a theory that oestrogen production pathways other than the aromatisation of androstenedione into oestrone may be intact in patients receiving aminoglutethimide treatment.…”

Influence of the Maturity of the Vaginal Epithelium upon the Absorption of Vaginally Administered Estradiol-17β and Progesterone in Postmenopausal Women

“…A sim ilar association between vaginal hormone cytology and serum 'total' estrogens, i.e., E[ + E2, in postmenopausal women has previously been shown by Benjamin and Deutsch [3]. These findings further confirm the superior ity of E| or E| + E2 assay compared to E2 when studying the estrogen status in subjects with mainly extragonadal estrogen sources, i.e., postmenopausal women and men [7,8],…”

Treatment of urogenital atrophy with low-dose estradiol: preliminary results

“…Previously published studies report an average metabolic clearance rate for E 2 in postmenpausal women of approximately 1,000 L/24 h. 37 Based on an average increment of E 2 of 2 pg/mL during a period of 4 h after each application, our calculations indicate that 0.33 µg …”

“…No comprehensive data are available on responses of urethral mucosa, although the slight increases in superficial cells observed in this study are within the ranges expected. 37 No systematic endometrial biopsy data have been obtained to compare acute versus chronic absorption of estrogen. 33,[39][40][41][42] In general, progesterone withdrawal challenge has been used as a noninvasive means to detect endometrial stimulation.…”

Alterations in the production rate and the metabolism of oestrone and oestrone sulphate in breast cancer patients treated with aminoglutethimide

“…The clearance and production rates for oestrone in our patients were in the lower range. but consistent with results reported previously for breast cancer patients and normal postmenopausal women (Judd et al, 1982;Kirschner et al, 1978;Longcope & Williams, 1974;Reed et al, 1986). The plasma clearance of oestrone sulphate was similar to values found by us in a previous investigation (L0nm 'ng et al, 1987), the oestrone sulphate production rate was found somewhat lower than values reported for young men and menstruating women in the follicular phase of cyclus (Longcope, 1972;Ruder et al, 1972 (Noel et al, 1979).…”

“…However, in recent years the hypothesis that post-menopausal oestrogen production does occur by peripheral aromatisation of androstenedione only has been challenged (Kirschner et al, 1978: Longcope et al, 1982Reed et al, 1986). Our results indirectly support a theory that oestrogen production pathways other than the aromatisation of androstenedione into oestrone may be intact in patients receiving aminoglutethimide treatment.…”

Influence of the Maturity of the Vaginal Epithelium upon the Absorption of Vaginally Administered Estradiol-17β and Progesterone in Postmenopausal Women

“…A sim ilar association between vaginal hormone cytology and serum 'total' estrogens, i.e., E[ + E2, in postmenopausal women has previously been shown by Benjamin and Deutsch [3]. These findings further confirm the superior ity of E| or E| + E2 assay compared to E2 when studying the estrogen status in subjects with mainly extragonadal estrogen sources, i.e., postmenopausal women and men [7,8],…”

Treatment of urogenital atrophy with low-dose estradiol: preliminary results

“…Previously published studies report an average metabolic clearance rate for E 2 in postmenpausal women of approximately 1,000 L/24 h. 37 Based on an average increment of E 2 of 2 pg/mL during a period of 4 h after each application, our calculations indicate that 0.33 µg …”

“…No comprehensive data are available on responses of urethral mucosa, although the slight increases in superficial cells observed in this study are within the ranges expected. 37 No systematic endometrial biopsy data have been obtained to compare acute versus chronic absorption of estrogen. 33,[39][40][41][42] In general, progesterone withdrawal challenge has been used as a noninvasive means to detect endometrial stimulation.…”