Estrogen-dependent cell signaling and apoptosis in BRCA1-blocked BG1 ovarian cancer cells in response to plumbagin and other chemotherapeutic agents

Thasni, K. A.; Rakesh, S; Rojini, G; Ratheeshkumar, T.; Srinivas, G; Priya, Sulochana

doi:10.1093/annonc/mdm557

Cited by 72 publications

(67 citation statements)

References 22 publications

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“…It has furthermore been shown to exert anti-proliferation influence in diverse cancer cell lines, both in vivo and in vitro, such as leukemia (Xu et al, 2010), prostate (Aziz et al, 2008;Powolny et al, 2008), breast Ahmad et al, 2008), ovarian (Thasni et al, 2008), cervical (Srinivas et al, 2004;Nair et al, 2008) and melanoma examples.…”

Section: Research Articlementioning

confidence: 99%

Plumbagin from Plumbago Zeylanica L Induces Apoptosis in Human Non-small Cell Lung Cancer Cell Lines through NF-κB Inactivation

Xu¹,

Shen²,

Liu³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Section: Research Articlementioning

confidence: 99%

Plumbagin from Plumbago Zeylanica L Induces Apoptosis in Human Non-small Cell Lung Cancer Cell Lines through NF-κB Inactivation

Xu¹,

Shen²,

Liu³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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“…In a study to evaluate the differential ability of selected compounds to inhibit cell growth in relation to BRCA1 (breast cancer 1, early onset) status in ER-positive ovarian cancer cells (Thasni et al 2008), plumbagin was found to be the most effective inducer of apoptosis through its binding to and modulation of ER-alpha in BRCA1 silenced cells. In an earlier study, the effect of tamoxifen, emodin, and plumbagin was analyzed in BRCA1-silenced ovarian cancer cells that express ER (Srinivas et al 2004a).…”

Section: Other Cancersmentioning

confidence: 99%

Role of Novel Nutraceuticals Garcinol, Plumbagin and Mangiferin in the Prevention and Therapy of Human Malignancies: Mechanisms of Anticancer Activity

Ahmad

Padhyé

Sarkar

2011

Nutraceuticals and Cancer

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Nutraceuticals from natural sources have been investigated for their putative chemopreventive and cancer therapeutic properties for the last few decades. The interest in these compounds is in part due to their pleiotropic effects and relatively non-toxic nature. A large number of such nutraceuticals are under detailed investigations worldwide but most of them suffer from the lack of sufficient bioavailability in humans. The identification and characterization of novel natural compounds with sufficient anticancer potential is therefore an ongoing process. This article is a summary of anticancer activity of three such novel nutraceuticals, namely garcinol, plumbagin and mangiferin. These compounds have shown promising biological activity in preliminary studies by targeting multiple signaling pathways. In particular, it seems that the inhibition of NF-κB pathway is one of the major mechanism through which these compounds exhibit their anticancer and apoptosis-inducing effects. The data on their anticancer activity is just emerging and the information on their bioavailability is still insufficient to predict their future application in the clinical settings. In this article, we have surveyed the available literature to summarize the mechanisms of anticancer activity of these three novel nutraceuticals. We also discuss the challenges and possible solutions to realize the dream on the translational potential of these compounds into clinical practice for the prevention and/or treatment of human malignancies.

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“…It has been shown that PL has anticarcinogenic and cytotoxic affects on animal models and various cancer cells [16,[19][20][21][22]. It has furthermore been shown to exert antiproliferation influence in diverse cancer cell lines, both in vivo and in vitro [18], such as leukemia [23], prostate [17,24], breast [20,25], ovarian [26], lung [21] and melanoma [27] examples. Sinha and his colleagues carried out in vivo studies on ovarian cancer cells and they concluded that PL is a promising antiangiogenic drug [28].…”

Section: Introductionmentioning

confidence: 99%

99mTc labeled plumbagin: estrogen receptor dependent examination against breast cancer cells and comparison with PLGA encapsulated form

Kılçar

Tekin

Müftüler

et al. 2015

J Radioanal Nucl Chem

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Plant origin products having anticancer properties come into prominence due to widespread of cancer. Plumbagin has various biological activities like anticancer activity. Estrogen receptor (ER) specificity of plumbagin (PL) and radiolabeled PL investigated by in vitro studies on ER? and ER-adenocarcinoma cells. Additionally, PLGA encapsulation was carried out to reduce toxicity of plumbagin and encapsulation effect was investigated. Plumbagin radiolabeled with 100 % in yields and had ER specificity. Furthermore, PLGA encapsulation effected positively on properties of plumbagin; reduced toxicity, increased stability and ER specificity. A promising agent for the diagnosis of ER? breast cancer is suggested.

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Estrogen-dependent cell signaling and apoptosis in BRCA1-blocked BG1 ovarian cancer cells in response to plumbagin and other chemotherapeutic agents

Abstract: Taken together, this study indicates that plumbagin has chemotherapeutic potential in BRCA1-mutated/defective ER-positive cancers.

Cited by 72 publications

References 22 publications

Plumbagin from Plumbago Zeylanica L Induces Apoptosis in Human Non-small Cell Lung Cancer Cell Lines through NF-κB Inactivation

Plumbagin from Plumbago Zeylanica L Induces Apoptosis in Human Non-small Cell Lung Cancer Cell Lines through NF-κB Inactivation

Role of Novel Nutraceuticals Garcinol, Plumbagin and Mangiferin in the Prevention and Therapy of Human Malignancies: Mechanisms of Anticancer Activity

99mTc labeled plumbagin: estrogen receptor dependent examination against breast cancer cells and comparison with PLGA encapsulated form

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