Estrogen and progesterone receptors in melanocytic lesions. Occurrence in patients with dysplastic nevus syndrome

Ellis, Darrel L.

doi:10.1001/archderm.121.10.1282

Cited by 8 publications

(8 citation statements)

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“…It has been shown that primary cutaneous melanomas, dysplastic nevi, and benign nevi contain large numbers of estrogen-and progesterone-binding cells. In contrast, acquired intradermal nevi show little or no detectable estrogen or progesterone binding [5,13]. Congenital nevi also show high concentrations of estrogen-binding and progesterone-binding nevus cells in both male and female patients [6].…”

Section: Discussionmentioning

confidence: 99%

Expression of sex hormone receptors and cell cycle proteins in melanocytic lesions of the ocular conjunctiva

Pache

Glatz-Krieger

Sauter

et al. 2005

Graefe's Arch Clin Exp Ophthalmo

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Section: Discussionmentioning

confidence: 99%

Expression of sex hormone receptors and cell cycle proteins in melanocytic lesions of the ocular conjunctiva

Pache

Glatz-Krieger

Sauter

et al. 2005

Graefe's Arch Clin Exp Ophthalmo

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“…Although the impact of age was not specifically addressed in this study, our experience is these changes are much more prevalent in young adults than in the elderly. The role estrogen plays in the biology and altered histology of breast lesions is intriguing 29,30 but yet unfounded. These features are found on breast lesions of both men and women and are not restricted to the papillomatous variety of pregnancy, 31 for now arguing against the sole impact of the hormonal milieu.…”

Section: Breastmentioning

confidence: 99%

Nevi with site‐related atypia: a review of melanocytic nevi with atypical histologic features based on anatomic site

2008

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A subset of melanocytic nevi share features with melanoma and nevi with architectural disorder but are biologically inert and to date do not appear to portend an increased risk for the development of malignancy. These benign nevi with certain atypical histologic features cluster among specific anatomic sites and are thus designated nevi with site-related atypia. We categorize these lesions into four main groups: acral, genital, special site and conjunctival, based on anatomy and relative prevalence of specific atypical histologic features. As the literature and our recognition of these lesions continue to grow, our understanding of their biology has not kept pace.Hosler GA, Moresi JM, Barrett TL. Nevi with site-related atypia: a review of melanocytic nevi with atypical histologic features based on anatomic site.

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“…Randomly selected archived paraffin blocks (n ¼ 94) were acquired in a de-identified manner from the Vanderbilt-Ingram Cancer Center Tissue Acquisition Core in accordance with HIPPA guidelines and with the approval of Vanderbilt University Institutional Review Board. Lesions were categorized by their previous dermatopathologic diagnosis and the patient's gender, into the following categories: benign nevi (10), congenital nevi (10), mild dysplastic nevi (10), moderate dysplastic nevi (9), severe dysplastic nevi (10), lentigo maligna (9), melanoma <1 mm deep (10), melanoma 1-4 mm deep (7), melanoma >4 mm deep (13), and metastatic melanoma (6).…”

Section: Tissue Acquisitionmentioning

confidence: 99%

“…Prior to the first cloning of an oestrogen receptor in 1986 (1), the presence of an oestrogen receptor or binding protein in melanocytic lesions was indirectly demonstrated by using ligand-binding methods (2)(3)(4)(5)(6)(7)(8). Subsequently, monoclonal antibodies were developed against what is now recognized as oestrogen receptor alpha (ERa).…”

Section: Introductionmentioning

confidence: 99%

Oestrogen receptor‐β expression in melanocytic lesions

Schmidt¹,

Nanney²,

Boyd³

et al. 2006

Experimental Dermatology

125

146

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Melanomas rarely occur before puberty, have a higher death rate for males, and tend to be more invasive during pregnancy. Prior to the discovery of a second oestrogen receptor (ERbeta), studies with the initial oestrogen receptor, ERalpha, showed no obvious role for oestrogen in the pathophysiology of benign or malignant melanocytic lesions. To investigate the specific immunostaining patterns of ERalpha and ERbeta, benign nevocytic nevi, dysplastic nevi with mild, moderate and severe cytological atypia, lentigo malignas and melanomas of varying depth (Clark) and thickness (Breslow) were studied. ERbeta but not ERalpha was the predominant oestrogen receptor we found in all types of benign and malignant melanocytic lesions. The most intense ERbeta immunostaining was seen in melanocytes in dysplastic nevi with severe cytological atypia and in lentigo malignas. ERbeta expression levels also correlated with the malignant tumor microenvironment; i.e., melanocytes in proximity with keratinocytes>deeper dermal melanocytes in contact with stroma>minimally invasive melanomas>Clark Level III/IV or thick melanomas (Breslow). Discovery that ERbeta expression varies in relation to the tumor microenvironment and increasing depth of invasion suggests its possible usefulness as a surrogate marker for neoplasia and prognosis in malignant melanoma.

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Estrogen and progesterone receptors in melanocytic lesions. Occurrence in patients with dysplastic nevus syndrome

Cited by 8 publications

References 0 publications

Expression of sex hormone receptors and cell cycle proteins in melanocytic lesions of the ocular conjunctiva

Expression of sex hormone receptors and cell cycle proteins in melanocytic lesions of the ocular conjunctiva

Nevi with site‐related atypia: a review of melanocytic nevi with atypical histologic features based on anatomic site

Oestrogen receptor‐β expression in melanocytic lesions

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