Estrés oxidativo en la asfixia perinatal y la encefalopatía hipóxico-isquémica

Núñez, Antonio Rodríguez; Benavente, Isabel; Blanco, D.; Boix, Héctor; Cabañas, Fernando; Chaffanel, Mercedes; Fernández-Colomer, Belén; Loureiro, Begoña; Moral, Mónica; Pavón, Antonio; Tofé, Inés; Valverde, Eva; Vento, Máximo

doi:10.1016/j.anpedi.2017.05.005

Cited by 12 publications

(9 citation statements)

References 38 publications

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“…At birth, following the initiation of respiration, alveolar oxygen tension and ventilation increase; however, asphyxia at birth can interfere with the pulmonary transition during birth, thus increasing the risk for severe pulmonary hypertension. Perinatal asphyxia induces a marked reduction in enzyme nitric oxide synthase (NOS), which requires the presence of oxygen for the production of endogenous NO ( 17 ). Besides, a key factor for determining the bioavailability of NO in a tissue is the local concentration of superoxide anions.…”

Section: Discussionmentioning

confidence: 99%

Asphyxia and Neonatal Respiratory Distress Syndrome Are Independent Predictors of the Non-response to Inhaled Nitric Oxide in the Newborns With PPHN

et al. 2021

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Aim: Not all the neonates respond with improvement in oxygenation following inhaled nitric oxide treatment (iNO) treatment. The aim of this study was to assess the independent risk factors associated with non-response to iNO during the 2 weeks of postnatal treatment in neonates diagnosed with persistent pulmonary hypertension (PPHN).Materials and Methods: This retrospective cohort study included all newborns with PPHN who received iNO treatment for more than 24 h. Demographic, obstetric, perinatal data and clinical complications were extracted from the hospitalization records. Subjects were divided into two groups according to their response to iNO inspiration during the first 24 h of iNO treatment. No response was defined as an increase in SpO2 < 5% or the inability to sustain saturation levels in the first 24 h of iNO treatment. For descriptive statistics, χ2 and t-test analysis were used to compare categorical and continuous variables between the two groups. To evaluate independent risk factors of non-responsiveness to iNO treatment, binary logistic regression analysis were performed.Results: A total of 75 newborns were included in the study. Sixty-two cases were in the responders group, and 13 cases were in the non-responders group. Univariate analysis showed that asphyxia, neonatal respiratory distress syndrome (NRDS), pulmonary surfactant administration, meconium aspiration syndrome (MAS), the severity of pulmonary hypertension (PH), and high-frequency oscillatory ventilation (HFOV) therapy were the high-risk factors affecting the response to iNO treatment in the newborns with PPHN. The binary logistic regression analysis indicated that asphyxia and NRDS incidence were independent predictors of non-responsiveness to iNO treatment [asphyxia: OR 4.193, 95% CI 1.104–15.927, P = 0.035; NRDS: OR 0.154, 95% CI 0.036–0.647, P = 0.011]. The patients in the non-responders group had shorter iNO inspiration followed by MV duration, supplemental oxygen and hospital stay, and higher mortality. There were no significant differences in IVH, PVL, and BPD between two groups.Conclusion: In the newborns with PPHN, asphyxia and NRDS resulted as the independent risk factors of non-responsiveness to iNO therapy. Asphyxia in the newborns with PPHN is detrimental to the response to iNO treatment, while NRDS is beneficial.

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Section: Discussionmentioning

confidence: 99%

Asphyxia and Neonatal Respiratory Distress Syndrome Are Independent Predictors of the Non-response to Inhaled Nitric Oxide in the Newborns With PPHN

et al. 2021

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“…It is then that hypothermia produces a decrease in the metabolic activity of tissues, like the central nervous system (SNC), with the subsequent diminution of the ionic exchange needs and, hence, of adenosine triphosphate (ATP) consumption. This reduction in the mitochondrial activity and the binding of decoupling proteins reduces the generation of reactive species without losing the transmembrane potentials and blocking the release of apoptogenic proteins (Lehtonen et al 2017;Nuñez et al 2018).…”

Section: Physiological Response To Hypothermiamentioning

confidence: 99%

“…Some peripartum complications that predispose to hypoglycemia are a placental failure, premature birth, hypoxia, hypogalactia or agalactia, and adverse environmental conditions (Lawler, 2008). Hence, glucose and lack of oxygen lead to a fast deterioration of the energetic reserves and, in a short time, to tissue death (Nuñez et al 2018).…”

Section: Accepted Articlementioning

confidence: 99%

Thermal homeostasis in the newborn puppy: behavioral and physiological responses

Reyes-Sotelo

Mota-Rojas

Martı́nez-Burnes

et al. 2021

JABB

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“…Los Radicales Libres (RL) y el estrés oxidativo están asociados con un gran número de enfermedades, como el cáncer, la aterosclerosis, enfermedades neurodegenerativas, diabetes mellitus, lesiones por isquemia-reperfusión, entre otras; pudiendo además causar destrucción de las mitocondrias y el bloqueo en la generación de energía (Carrillo et al, 2016;Núñez et al, 2017;Rodríguez y Camejo, 2018;Mora et al, 2019). En contraposición, el organismo secreta sustancias, como la melatonina que elimina los radicales libres; además de otras moléculas como la catalasa, glutation sintasa, glutation peroxidasa, glutation reductasa, glucosa deshidrogenasa y superóxido dismutasa; enzimas antioxidantes que bloquean la producción de especies reactivas del oxígeno (ROS) y la respuesta inflamatoria (González-Ibarra et al, 2011;León-Páez et al, 2015;León et al, 2018).…”

Section: Introductionunclassified

The hydroalcoholic extract of Plantago major "llantén" increases the Catalase activity in Oryctolagus cuniculus "rabbits"

Pretel-Sevillano¹,

Calderón-Peña²,

Torres-Plasencia³

et al. 2020

Agroind. sci.

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Estrés oxidativo en la asfixia perinatal y la encefalopatía hipóxico-isquémica

Cited by 12 publications

References 38 publications

Asphyxia and Neonatal Respiratory Distress Syndrome Are Independent Predictors of the Non-response to Inhaled Nitric Oxide in the Newborns With PPHN

Asphyxia and Neonatal Respiratory Distress Syndrome Are Independent Predictors of the Non-response to Inhaled Nitric Oxide in the Newborns With PPHN

Thermal homeostasis in the newborn puppy: behavioral and physiological responses

The hydroalcoholic extract of Plantago major "llantén" increases the Catalase activity in Oryctolagus cuniculus "rabbits"

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