Estradiol in Premenstrual Asthma: A Double‐Blind, Randomized, Placebo‐Controlled, Crossover Study

Ensom, Mary H H; Chong, Gina; Zhou, Danyi; Beaudin, Bev; Shalansky, Stephen; Bai, Tony R.

doi:10.1592/phco.23.5.561.32201

Cited by 28 publications

(12 citation statements)

References 45 publications

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“…Most publications describing a protective effect are intervention studies or case reports. 19,30,36 The effect of OCs on respiratory symptoms has been associated with asthma severity or asthma status, 21,23,37 a hypothesis that we could not investigate in our sample because of the relatively small number of subjects with asthma and similar severity.…”

Section: Discussionmentioning

confidence: 99%

Perimenstrual increase in bronchial hyperreactivity in premenopausal women: Results from the population-based SAPALDIA 2 cohort

Dratva

Schindler

Ivan

et al. 2010

Journal of Allergy and Clinical Immunology

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Section: Discussionmentioning

confidence: 99%

Perimenstrual increase in bronchial hyperreactivity in premenopausal women: Results from the population-based SAPALDIA 2 cohort

Dratva

Schindler

Ivan

et al. 2010

Journal of Allergy and Clinical Immunology

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“…This enables later comparisons between studies to be far more objective than the simple answer to the question ''Does your asthma get worse before menstruation?'' This definition is applied in epidemiological studies and especially in clinical trials [8,9], to compare the effect of various treatments on PMA.…”

Section: Discussionmentioning

confidence: 99%

“…In this regard, authors such as ENSOM and coworkers [4,9,13] and PASAOGLU et al [8] believe the evaluation of only one menstrual cycle to be sufficient for cataloguing PMA and for designing a subsequent clinical trial. In addition, AGARWAL and SHAH [2] report that .61% of patients with PMA show premenstrual deterioration in all cycles, 39% every two or three cycles and only one patient felt worse every three or four cycles.…”

Section: Discussionmentioning

confidence: 99%

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Variability in the prevalence of premenstrual asthma

Vega¹,

Sánchez-Ramos²,

Pérez³

et al. 2009

European Respiratory Journal

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Our aim is to analyse the differences in the prevalence of premenstrual asthma (PMA) according to a set of criteria, the relationship between them and the influence of asthma severity.The answer ''Yes'' to ''Does your asthma get worse before menstruation?'' was considered subjective PMA. A daily respiratory symptoms register of fertile asthmatic females was taken during two consecutive menstrual cycles. For the semi-objective diagnosis, an exacerbation of o20% was required in the symptoms register. Objective diagnosis was a premenstrual worsening of o20% of peak flow.We selected 103 patients. Subjective premenstrual deterioration was perceived in 43.7%. The semi-objective deterioration of symptoms in the first cycle occurred in 44.7%, and in 22.3% in both cycles. A total of 54.3% of females with semi-objective criteria in the first cycle perceived a subjective deterioration of symptoms, versus 35.1% of those without semi-objective criteria (p50.05). PMA was present at all levels of asthma severity, with no clear link to the degree of severity.The detection of PMA prevalence, the subjective perception of this deterioration and its presence at all levels of asthma severity lead us to urge research into possible premenstrual deterioration in all fertile asthmatic females.

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“…Ensom et al (43) were unable to show a beneficial effect of estradiaol in 12 women with documented PMA but otherwise mild asthma. Further trials in women with PMA and more severe asthma were suggested by the authors.…”

Section: Progesterone/oral Contraceptivesmentioning

confidence: 91%

Premenstrual Asthma: Emphasis on Drug Therapy Options

Redmond

James

Nolan³

et al. 2004

J Asthma

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Premenstrual asthma is quite common, affecting up to 40% of women. Some studies suggest exacerbations of asthma requiring emergency department visits or hospitalizations are more common in the perimenstrual phase. Several drug treatment modalities for premenstrual asthma have been evaluated. Drug therapies that may be beneficial include leukotriene receptor antagonists, long acting inhaled beta2 agonists, progesterone, estradiol, and gonadotropin-releasing hormone (GnRH) analogs. Further double-blind, randomized, placebo-controlled studies are required before the optimal drug therapy for premenstrual asthma is established.

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Estradiol in Premenstrual Asthma: A Double‐Blind, Randomized, Placebo‐Controlled, Crossover Study

Cited by 28 publications

References 45 publications

Perimenstrual increase in bronchial hyperreactivity in premenopausal women: Results from the population-based SAPALDIA 2 cohort

Perimenstrual increase in bronchial hyperreactivity in premenopausal women: Results from the population-based SAPALDIA 2 cohort

Variability in the prevalence of premenstrual asthma

Premenstrual Asthma: Emphasis on Drug Therapy Options

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