Estimation of Serum Malondialdehyde before and after Radiotherapy in Oral Squamous Cell Carcinoma Patients Undergoing Antioxidant Therapy

Patait, Mahendra; Mody, RN; Kailasam, S

doi:10.5005/jp-journals-10011-1223

Cited by 2 publications

(2 citation statements)

References 24 publications

(25 reference statements)

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“…Many anticancer treatments including chemotherapy, radiotherapy, immune cells and cytokine treatment elicit the production of ROS within tumors [6][7][8][9][10]. Previous studies have also established that cancer therapeutics, including chemotherapy, radiotherapy, hyperthermia, immune cell activation, and cytokine treatment, promote activation of the lipid peroxidation pathway in vitro and within patients [23][24][25][26][27][28]. This study shows that WO 3 /Pt nanoparticles retain their catalytic activity within tumor cells to synthesize ROS, elicit activation of the lipid peroxide pathway and destabilize lysosomes.…”

Section: Discussionmentioning

confidence: 99%

WO₃/Pt nanoparticles promote light-induced lipid peroxidation and lysosomal instability within tumor cells

Clark

Petty

2016

Nanotechnology

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Although metal-metal oxide nanoparticles have attracted considerable interest as catalysts, they have attracted little interest in nanomedicine. This is likely due to the fact that metal oxide semiconductors generally require biologically harmful ultraviolet excitation. In contrast, this study focuses upon WO3/Pt nanoparticles, which can be excited by visible light. To optimize the nanoparticles' catalytic performance, platinization was performed at alkaline pH. These nanoparticles destroyed organic dyes, consumed dissolved oxygen and produced hydroxyl radicals. 4T1 breast cancer cells internalized WO3/Pt nanoparticles within the membrane-bound endo-lysosomal compartment as shown by electron and fluorescence microscopy. During visible light exposure, but not in darkness, WO3/Pt nanoparticles manufacture reactive oxygen species, promote lipid peroxidation, and trigger lysosomal membrane disruption. As cells of the immune system degrade organic molecules, produce reactive oxygen species, and activate the lipid peroxidation pathway within target cells, these nanoparticles mimic the chemical attributes of immune effector cells. These biomimetic nanoparticles should become useful in managing certain cancers, especially ocular cancer.

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Section: Discussionmentioning

confidence: 99%

WO₃/Pt nanoparticles promote light-induced lipid peroxidation and lysosomal instability within tumor cells

Clark

Petty

2016

Nanotechnology

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“…NO was estimated by the colorimetric method based on the Griess reaction 23 . Malondialdehyde (MDA) was determined by a simple and sensitive spectrophotometric method and Thiobarbituric acid (TBA) reagent from (Merck KGaA, Darmstadt, Germany) used 24 .…”

Section: Clinical Parametersmentioning

confidence: 99%

Ghrelin and Leptin and Their Relations with Insulin Resistance in Diabetes Mellitus Type 2 Patients

2022

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Ghrelin and leptin are hunger hormones related to type 2 diabetes mellitus (T2DM), and the pathogenesis of T2DM is the abnormality in insulin secretion and insulin resistance (IR). The aim of this study is to evaluate ghrelin and leptin concentrations in blood and to specify the relationship of these hormones as dependent variables with some biochemical and clinical measurements in T2DM patients. In this study, forty one T2DM and forty three non-diabetes mellitus (non-DM) subjects, aged between 40-60 years and with normal weight, were enrolled. Fasting serum ghrelin and leptin were estimated by enzymelinked immunosorbent assay (ELISA). In our results ghrelin was significantly increased, and leptin was significantly decreased, in T2DM patients compared with non-DM subjects. Ghrelin was positively correlated with the fasting blood glucose (FBG) and IR, but inversely related to the insulin sensitivity (IS). Leptin was negatively correlated with mean arterial pressure (MAP), FBG, glycated hemoglobin (HbA1c), IR, low-density lipoprotein cholesterol, nitric oxide (NO), and alanine aminotransferase (ALT), as well as showed a linear correlation with IS and a strong dependence on sex. The area under the curve (AUC) value shows ghrelin and leptin as biomarkers for T2DM. In conclusion ghrelin and leptin hormones have predictive ability to predict T2DM, as they are significantly associated with IR, IS, free radicals, and lipid profile.

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Estimation of Serum Malondialdehyde before and after Radiotherapy in Oral Squamous Cell Carcinoma Patients Undergoing Antioxidant Therapy

Cited by 2 publications

References 24 publications

WO₃/Pt nanoparticles promote light-induced lipid peroxidation and lysosomal instability within tumor cells

WO₃/Pt nanoparticles promote light-induced lipid peroxidation and lysosomal instability within tumor cells

Ghrelin and Leptin and Their Relations with Insulin Resistance in Diabetes Mellitus Type 2 Patients

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Estimation of Serum Malondialdehyde before and after Radiotherapy in Oral Squamous Cell Carcinoma Patients Undergoing Antioxidant Therapy

Cited by 2 publications

References 24 publications

WO3/Pt nanoparticles promote light-induced lipid peroxidation and lysosomal instability within tumor cells

WO3/Pt nanoparticles promote light-induced lipid peroxidation and lysosomal instability within tumor cells

Ghrelin and Leptin and Their Relations with Insulin Resistance in Diabetes Mellitus Type 2 Patients

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WO₃/Pt nanoparticles promote light-induced lipid peroxidation and lysosomal instability within tumor cells

WO₃/Pt nanoparticles promote light-induced lipid peroxidation and lysosomal instability within tumor cells