Estimation of Serum Levels of C - reactive protein in Periodontitis Patients – An Observational Study

Abstract

Background: C-reactive protein (CRP) is an emerging prognostic biomarker in patients with periodontitis and cardiovascular disease. There is a proposed pathophysiological mechanism that links periodontitis with cardiovascular disease. Early detection of periodontitis patients with cardiovascular disease events helps in accurate diagnosis and better treatment plan. But there are limited studies in the literature on serum C- reactive protein levels in periodontitis patients. Aim: This observational study aimed to investigate the associations between periodontitis severity and the serum levels of CRP in comparison with healthy and periodontitis group. Materials & Methodology: A total of 30 patients who were divided into two groups of study and control group consist of 15 patients in each group. Patients were selected based on inclusion and exclusion criteria. Blood sample collection was done by trained professional and serum samples were stored at -80 degree Celsius. The C-reactive protein levels were measured using a high‐sensitivity enzyme‐linked immunosorbent assay. Results: The mean value of 12923.41 in C-reactive protein (CRP) serum levels in gingivitis group with the standard deviation of 10272.22 was obtained with the p value of 0.01. The mean of 3994.86 in C-reactive protein (CRP) serum levels in periodontitis group with the standard deviation of 5110.81 was obtained with the p value of 0.01 with the p value of 0.01. Serum C-reactive protein levels showed statistically significant results when compared between the control and study group. Conclusion: There is a pathophysiological mechanism that links the cardiovascular diseases with periodontitis; the serum C-reactive protein levels are higher in periodontitis patients. The serum CRP levels and may be used as a cardiac biomarker in periodontitis patients.

How widespread is Thyroid Disorders among Patients undergoing Coronary Artery Bypass Grafting? A Study from Tertiary Care Hospital

“…[13] In case of hypothyroidism, heart ejects less amount of blood per heartbeat as it is unable to pump forcefully, this is because the heart muscles are weakened in both contraction and relaxation phase. [14] Diastolic dysfunction, bradycardia and pericardial effusion are some of the common manifestations of an untreated hypothyroidism. [15] On the other hand, tachycardia, widened pulse pressure, increased cardiac output, and decreased total peripheral resistance are manifestations of hyperthyroidism.…”