Abstract:An experimental study performed to investigate the effect of nanofluid forced convection heat transfer and fluid flow characteristic. Three types of nanofluids {γAl 2 O 3 , CuO and ZrO 2 -DIW} flow under laminar or turbulent condition in inner pipe. The shear thinning behavior of blood is more accurately modeled by non-Newtonian Blood Mimic Fluids BMF. Here heat transfer and friction factor correlations developed for nonreactive Newtonian and non-Newtonian BMF fluids of (water: glycerol: xanthan gums) and heparinized bovine blood. The results show that the BMF Nussult number (Nu b ) increased as increasing Graetz number, and as flow index (n) decreasing. Bovine blood gives the temperatures distribution similar to (BMF6) but with lower Nusselt number by (31.2%). The BMF friction factor increases with decreasing (n), but the Bovine blood gives higher friction factor as compared with BMF6 by (25.6%). It was observed that all nanofluids types showed higher heat transfer characteristics than the base fluid DIW. It was also noted that in the γAl 2 O 3 shows higher enhancement than the other by (82.4%) at (Re nf =12670) and (ɸ=1 vol.%). Comparisons present experimental results with previously reported results it gives good agreement.