Estimating the Global Incidence of Femoral Fracture from Road Traffic Collisions

Agarwal-Harding, Kiran J.; Meara, John G.; Greenberg, Sarah L M; Hagander, Lars; Zurakowski, David; Dyer, George S.M.

doi:10.2106/jbjs.n.00314

Cited by 75 publications

(58 citation statements)

References 21 publications

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“…Fractures of the femoral and tibia shaft often occur in response to high energy trauma and are preferentially treated by an intramedullary nail that supports the fracture zone and facilitates bone healing [1][2][3]. The intramedullary stabilization usually remains since implant removal in general and extraction of a nail in particular can be very time-consuming, cumbersome and may cause further tissue damage, refracture and other subsequent problems [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Intramedullary Mg2Ag nails augment callus formation during fracture healing in mice

Jähn¹,

Saito

Taipaleenmäki

et al. 2016

Acta Biomaterialia

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Intramedullary stabilization is frequently used to treat long bone fractures. Implants usually remain unless complications arise. Since implant removal can become technically very challenging with the potential to cause further tissue damage, biodegradable materials are emerging as alternative options. Magnesium (Mg)-based biodegradable implants have a controllable degradation rate and good tissue compatibility, which makes them attractive for musculoskeletal research. Here we report for the first time the implantation of intramedullary nails made of an Mg alloy containing 2% silver (Mg2Ag) into intact and fractured femora of mice. Prior in vitro analyses revealed an inhibitory effect of Mg2Ag degradation products on osteoclast differentiation and function with no impair of osteoblast function. In vivo, Mg2Ag implants degraded under non-fracture and fracture conditions within 210 days and 133 days, respectively. During fracture repair, osteoblast function and subsequent bone formation were enhanced, while osteoclast activity and bone resorption were decreased, leading to an augmented callus formation. We observed a widening of the femoral shaft under steady state and regenerating conditions, which was at least in part due to an uncoupled bone remodeling. However, Mg2Ag implants did not cause any systemic adverse effects. These data suggest that Mg2Ag implants might be promising for intramedullary fixation of long bone fractures, a novel concept that has to be further investigated in future studies.

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Section: Introductionmentioning

confidence: 99%

Intramedullary Mg2Ag nails augment callus formation during fracture healing in mice

Jähn¹,

Saito

Taipaleenmäki

et al. 2016

Acta Biomaterialia

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“…[1] Approximately 1 in 10 road injuries involves a femoral shaft fracture that is most effectively treated with surgery. [1] To our knowledge, intramedullary nail fixation is the most popular surgical method to perform an operation for the patients with femoral shaft fracture. As the population ages, the incidence of femoral shaft fractures in elder patients seems to increase.…”

Section: Introductionmentioning

confidence: 99%

The effect of lower limb rehabilitation gymnastics on postoperative rehabilitation in elderly patients with femoral shaft fracture

Yang

Ning

Zhang³

et al. 2016

Medicine

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The purpose of this study was to explore the effect of lower limb rehabilitation gymnastics on postoperative rehabilitation in elderly patients with femoral shaft fracture after undergoing intramedullary nail fixation surgery.We collected medical records of elderly patients aged ≥ 60 years with femoral shaft fracture between 03/2010 and 03/2015 in Longyao County Hospital. Totally, 160 patients were identified and divided into the intervention group (n = 80) and the control group (n = 80). During the postoperative period, the intervention group received lower limb rehabilitation gymnastics treatment for 3 months, but the control group did not. All patients were routinely asked to return hospital for a check in the 1st postoperative week, as well as the 2nd week, the 1st month, and the 3rd month, after surgery. The clinical rehabilitation effect was evaluated by checking lower limb action ability, detecting the lower limb deep venous thrombosis (DVT), scoring muscle strength of quadriceps and visual analog scale (VAS) score, and performing satisfaction survey.At the 1st week and 2nd week after surgery, the clinical rehabilitation effect in the intervention group was better regarding lower limb action ability, lower limb DVT, muscle strength of quadriceps, VAS score, and patient satisfaction, as compared with the control group. However, there was no significant difference at the 1st month and the 3rd month after surgery when comparing the intervention group to the control group.In the early postoperative stage, lower limb rehabilitation gymnastics can effectively improve the recovery of lower limb function, beneficial to reducing postoperative complications such as lower limb DVT and muscle atrophy, and increasing patient satisfaction rate.

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“…In high-income countries the annual incidence of femoral shaft fractures ranges between 8.2 and 23.9 per 100,000 people. Due to the high-energy mechanism, associated injuries are common in this patient population and the inhospital mortality has been reported to be approximately 1.4% [1][2][3]. In particular, musculoskeletal injuries to the ipsilateral limb, such as hip fractures, patella fractures, tibial plateau fractures, and ligamentous knee injuries have been reported to commonly occur in conjunction with high-energy femoral shaft fracture.…”

Section: Introductionmentioning

confidence: 99%

Complete Sciatic Nerve Transection Associated with a Closed Femoral Shaft Fracture

Zelle¹,

Webb²,

Cromack³

2016

J Trauma Treat

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We report a rare case of a 33-year-old female patient who sustained bilateral closed femoral shaft fractures as a result of motor vehicle collision. The left femoral shaft fracture was associated with primary complete sciatic nerve palsy. The patient underwent intramedullary nail fixation of both femoral shaft fractures. Throughout the postoperative course, no functional recovery was observed. Nerve conduction studies and magnetic resonance imaging studies confirmed the diagnosis of a complete transection of the sciatic nerve at the level of the fracture site. Subsequently, the patient underwent surgical exploration and nerve grafting resulting in improved nerve function. Reports on complete sciatic nerve transections associated with closed femoral shaft fractures are limited. We document a unique injury and illustrate the patient's management and outcome.

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Estimating the Global Incidence of Femoral Fracture from Road Traffic Collisions

Cited by 75 publications

References 21 publications

Intramedullary Mg2Ag nails augment callus formation during fracture healing in mice

Intramedullary Mg2Ag nails augment callus formation during fracture healing in mice

The effect of lower limb rehabilitation gymnastics on postoperative rehabilitation in elderly patients with femoral shaft fracture

Complete Sciatic Nerve Transection Associated with a Closed Femoral Shaft Fracture

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