Esthesioneuroblastoma Isolated to the Maxillary Sinus Antrum Presenting as SIADH: A Case Report

Rasool, Alysha; Dadgostar, Anali; Manji, Jamil; Al-Asousi, Fahad; Javer, Amin R.

doi:10.1177/2473974x18792488

Cited by 9 publications

(8 citation statements)

References 4 publications

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“…Esthesioneuroblastoma is a rare neoplasm that arises from the nasal cavity's olfactory neuroepithelium. It shows bimodal age distribution, with peaks from the second to the third, as well as from the sixth to the seventh, decades of life [28]. In our case it was a 39-year-old male.…”

Section: Discussionmentioning

confidence: 51%

Clinicopathological features of 214 maxillary sinus pathologies. A ten-year single-centre retrospective clinical study

et al. 2020

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Background Diagnosis of maxillary sinus pathology must include the clinical radiological study (CRS) and histopathological analysis. The aim of this study is 1) to describe the clinicopathological features of maxillary sinus lesions, obtained successively in a single medical centre over the last 10 years and 2) to determine the sensitivity and specificity for the diagnosis of malignant lesions based exclusively on the CRS. Methods It is a single-centre observational retrospective clinical study on patients who attended the University Hospital Complex of Santiago de Compostela (CHUS) with sinus pathologies during the period of 2009–2019. Results The sample consisted of 133 men (62.1%) and 81 women (37.9%), with an average age of 46.9 years (SD = 18.8). In terms of frequency, the most frequent pathology was the unspecified sinusitis (44.4%), followed by polyps (18.2%), malignant tumours (9.8%), inverting papilloma (7.5%), fungal sinusitis (4.7%), cysts (3.7%), benign tumours (2.3%), mucocele (2.3%) and other lesions (1.9%). Cysts and benign tumours were diagnosed earliest Vs malignant tumours (65.2 years (SD = 16.1)) were diagnosed the latest (p < 0.001). Based only on the CRS for malignancies, diagnostic indexes were 71.4% sensitivity and 97.9% specificity, with a Kappa value of 0.68 with (p < 0.001). Conclusion Maxillary sinus pathology is very varied with therapeutic and prognostic repercussions. CRS is sometimes insufficient and histopathological confirmation is essential.

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Section: Discussionmentioning

confidence: 51%

Clinicopathological features of 214 maxillary sinus pathologies. A ten-year single-centre retrospective clinical study

et al. 2020

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“…Neuroendocrine tumours, including esthesioneuroblastoma, may cause paraneoplastic syndromes through the ectopic secretion of hormones such as ADH. Primary presentation with paraneoplastic symptoms, however, is uncommon, with only two previously reported cases of esthesioneuroblastoma of the sinuses presenting primarily as idiopathic SIADH 6 9…”

Section: Discussionmentioning

confidence: 99%

“…In Rasool et al’s case,6 a 28-year-old patient presented with non-specific sinonasal symptoms of nasal congestion, postnasal discharge and headache associated with a low serum sodium and high urine osmolality. Despite oral sodium chloride tablets and water restriction, SIADH persisted.…”

Section: Discussionmentioning

confidence: 99%

“…Esthesioneuroblastoma may rarely be associated with paraneoplastic syndromes, including ectopic hormone production. Eighteen cases of the syndrome of inappropriate anti-diuretic hormone (SIADH) associated with esthesioneuroblastoma have been reported to date 5 6. Most of these cases involved primary tumours located in the region of the cribriform plate.…”

Section: Introductionmentioning

confidence: 99%

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Isolated primary maxillary sinus esthesioneuroblastoma presenting as idiopathic syndrome of inappropriate antidiuretic hormone

2019

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Esthesioneuroblastoma is an uncommon tumour, and isolated primary involvement of the maxillary sinus is exceedingly rare. Esthesioneuroblastoma has infrequently been reported as a source of paraneoplastic ectopic hormone production. We report a case of isolated primary maxillary esthesioneuroblastoma, presenting as idiopathic syndrome of inappropriate antidiuretic hormone (SIADH). A 17-year-old girl presented with symptoms consistent with SIADH and no sino-nasal symptoms. MRI to exclude pituitary tumour revealed an isolated lesion of the right maxillary sinus. Biopsy demonstrated esthesioneuroblastoma. The lesion was removed endoscopically as a single en bloc specimen. Following resection, the sodium level returned to normal. This is only the third report in the literature of a primary maxillary esthesioneuroblastoma presenting as SIADH.

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“…To our knowledge, there are 41 cases in the literature of functional ONB inducing SIADH. [4][5][6][7][8][9][10]…”

Section: Introductionmentioning

confidence: 99%

Functional Olfactory Neuroblastoma Inducing Symptomatic SIADH

Heiland

Heiland²

2021

Ear Nose Throat J

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Olfactory neuroblastoma (ONB) is a rare malignancy of the sinonasal cavity, originating from neuroepithelial olfactory cells. Olfactory neuroblastoma can be difficult to diagnose due to its anatomic position and variable symptomatic presentation, leading to diagnosis at a more advanced stage. Here, we present the case of a 35-year-old man with no previous medical history who had a bicycle accident secondary to syncope. He was found to be hyponatremic and suspected to have syndrome of inappropriate antidiuretic hormone secretion (SIADH). In the workup of SIADH, a brain magnetic resonance imaging revealed a mass in the left middle meatus. The lesion secreted inappropriate amounts of ADH, resulting in symptomatic paraneoplastic SIADH. This ultimately led to the early recognition and successful resection of this rare ONB. The patient has remained disease-free for over 5 years. This case is a fortunate example of a functional malignancy of the sinonasal tract that was discovered early and successfully treated as a result of symptomatic SIADH.

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Esthesioneuroblastoma Isolated to the Maxillary Sinus Antrum Presenting as SIADH: A Case Report

Abstract: No sponsorships or competing interests have been disclosed for this article.

Cited by 9 publications

References 4 publications

Clinicopathological features of 214 maxillary sinus pathologies. A ten-year single-centre retrospective clinical study

Clinicopathological features of 214 maxillary sinus pathologies. A ten-year single-centre retrospective clinical study

Isolated primary maxillary sinus esthesioneuroblastoma presenting as idiopathic syndrome of inappropriate antidiuretic hormone

Functional Olfactory Neuroblastoma Inducing Symptomatic SIADH

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