Establishment and identification of an animal model of long-term exercise-induced fatigue

Yan, Kai; Gao, Haoyang; Liu, Xiaohua; Zhao, Zhonghan; Gao, Bo; Zhang, Lingli

doi:10.3389/fendo.2022.915937

Cited by 13 publications

(9 citation statements)

References 74 publications

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“…However, the results of the present study were inconsistent with those of previous studies. The blood biomarkers used in this study have been reported to increase during or immediately after exercise [ 4 ]. In the present study, blood samples were taken 2 days after the treadmill fatigue test was performed, which may not have reflected the results.…”

Section: Discussionmentioning

confidence: 99%

Ninjin’yoeito reduces fatigue-like conditions by alleviating inflammation of the brain and skeletal muscles in aging mice

Otsuka,

Matsuzaki,

Kakimoto

et al. 2024

PLoS ONE

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Fatigue can lead to several health issues and is particularly prevalent among elderly individuals with chronic inflammatory conditions. Ninjin’yoeito, a traditional Japanese herbal medicine, is used to address fatigue and malaise, anorexia, and anemia. This study aimed to examine whether relieving inflammation in the brain and skeletal muscle of senescence-accelerated mice prone 8 (SAMP8) could reduce fatigue-like conditions associated with aging. First, SAMP8 mice were divided into two groups, with and without ninjin’yoeito treatment. The ninjin’yoeito-treated group received a diet containing 3% ninjin’yoeito for a period of 4 months starting at 3 months of age. At 7 months of age, all mice underwent motor function, treadmill fatigue, and behavioral tests. They were then euthanized and the skeletal muscle weight, muscle cross-sectional area, and concentration of interleukin (IL)-1β and IL-1 receptor antagonist (IL-1RA) in both the brain and skeletal muscle were measured. The results showed that the ninjin’yoeito-treated group had higher motor function and spontaneous locomotor activity than the untreated group did and ran for significantly longer in the treadmill fatigue test. Moreover, larger muscle cross-sectional area, lower IL-1β concentrations, and higher IL-1RA concentrations were observed in both the brain and skeletal muscle tissues of the ninjin’yoeito-treated group than in the untreated group. The results suggest that ninjin’yoeito improves age-related inflammatory conditions in both the central and peripheral tissues and reduces fatigue.

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Section: Discussionmentioning

confidence: 99%

Ninjin’yoeito reduces fatigue-like conditions by alleviating inflammation of the brain and skeletal muscles in aging mice

Otsuka,

Matsuzaki,

Kakimoto

et al. 2024

PLoS ONE

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“…And more, muscle function is closely linked to exercise-induced fatigue. Exercise-induced fatigue influences efficiency of operations and leads to inability of muscles 15 . However, the treatment effect of EA on fatigue was not uncovered because of its sophisticated pathogenesis.…”

Section: Discussionmentioning

confidence: 99%

Ellagic Acid Protects Against Fatigue in Exercise Trained Mice

Xianchu¹,

Zhang²,

Liu³

2023

International J. of Pharmacology

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Background and Objective: Ellagic acid (EA) was demonstrated to have muscle protection in various pathological processes. Fatigue is closely related to skeletal muscle dysfunction. Hence, the current study revealed the protective property of EA on excessive exerciseinduced fatigue. Materials and Methods: Swimming was used to constitute the model of excessive exercise-induced fatigue. The experiment mice were administration of EA for 28 days. The exhaustive exercise time was tested by forced swimming test. Grip strength meter was used to measure muscle force. The indicators of energy substance, tissue injury, oxidative stress, inflammatory response and ATPase were detected by corresponding kit. Results: The presented research showed that EA had a prominent property on fatigue as represented by promoting swimming exhaustion time and aggrandizing grip strength. In excessive exercise, EA ameliorated the contents of glycogen located in muscle and liver tissues. In serum, EA lightened fatigue-related biochemical indicators as represented by reducing CK, LDH, ALT and AST levels. In skeletal muscle, EA accelerated SOD, CAT and GSH-PX activities and mitigated MDA level to restrain oxidative stress. Moreover, EA decreased TNF-" and IL-6 levels to attenuate inflammatory response. Lastly, GA increased Na + -K + -ATPase and Ca 2+ -Mg 2+ -ATPase activities to recover energy metabolism. Conclusion: Data revealed that EA led to an available reversal of oxidative stress, inflammatory response and abnormal energy metabolism in excessive exercise-treated mice.

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“…The average water area was 320 cm 2 per rat, the depth of water was 50 cm, and the water temperature was 34 ± 2 • C. The rats were removed from the water immediately after swimming to exhaustion, and the exhaustion time was recorded. The exhaustion was judged according to the criteria in the literature [15,16].…”

Section: Exhaustive Forced Swimming Testmentioning

confidence: 99%

Repeated Inhalation of Peppermint Essential Oil Improves Exercise Performance in Endurance-Trained Rats

et al. 2023

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Peppermint essential oil, being natural and safe, with antioxidant and anti-inflammatory properties, has long been a research interest in relieving fatigue and improving exercise performance. However, the related studies report controversial results, and the mechanisms remain unclear. Here we found that inhalation of peppermint essential oil significantly extended the exhaustion time in rats subjected to 2-week weight-bearing swimming training. Sprague-Dawley rats were subjected to a 2-week weight-loaded forced swimming regimen. Prior to each swimming session, the rats were administered peppermint essential oil via inhalation. An exhaustive swimming test was performed at the end of the protocol. Rats treated with essential oil had significantly extended time to exhaustion compared with exercised rats without essential oil treatment. In addition, treated rats also showed reduced oxidative damage induced by endurance exercise. Notably, the rats receiving two-week essential oil inhalation while not subjected to swimming training did not show improved exercise performance. The findings demonstrate that repeated inhalation of peppermint essential oil enhances the effects of endurance training and improves exercise performance partially by preventing oxidative damage.

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Establishment and identification of an animal model of long-term exercise-induced fatigue

Cited by 13 publications

References 74 publications

Ninjin’yoeito reduces fatigue-like conditions by alleviating inflammation of the brain and skeletal muscles in aging mice

Ninjin’yoeito reduces fatigue-like conditions by alleviating inflammation of the brain and skeletal muscles in aging mice

Ellagic Acid Protects Against Fatigue in Exercise Trained Mice

Repeated Inhalation of Peppermint Essential Oil Improves Exercise Performance in Endurance-Trained Rats

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