Establishing age/sex related serum creatinine reference intervals from hospital laboratory data based on different statistical methods

Pottel, Hans; Vrydags, Nicolas; Mahieu, Boris; Vandewynckele, Emmanuel; Croes, Kathleen; Martens, Frank

doi:10.1016/j.cca.2008.06.017

Cited by 159 publications

(163 citation statements)

References 21 publications

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“…Complications were recorded as per the Clavien Dindo classification. Normal serum creatinine was defined as 0.7-1.3 mg/dL for men and 0.6-1.1 mg/dL for women [4] , 0.24-0.36 mg/dL in infants [5] and more than 0.24-0.36 mg/dL in male, and 0.2-0.8 mg/dL in female children between 1-12 years of age. [6] …”

Section: Methodsmentioning

confidence: 99%

Giant hydronephrosis: still a reality!

Kaura

Kumar

Sokhal

et al. 2017

Turkish Journal of Urology

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Objective: Giant hydronephrosis (GH) is a rare entity in both developed and developing countries with less than 500 cases reported in the literature. Delayed diagnosis and management of GH, can result in long-term complications like hypertension, rupture of the kidney, renal failure and malignant change. We aim to highlight the importance of this often neglected entity and build a consensus for its early diagnosis and management. Material and methods:Patients with GH were thoroughly worked up, managed and followed up between June 2013 and December 2015 and epidemiologic, radiological, perioperative and follow-up data was recorded.Results: A total of 35 patients (adults and children) were reported. Flank pain in adults and abdominal lump in children were the most common clinical presentation. Percutaneous nephrostomy tube was placed in all patients and detailed work up was done to reach final diagnosis. Pelvi-ureteric junction obstruction (PUJO) was the final diagnosis in 32 patients (91.4%). Kidneys were non-functioning in 13 cases (37.1%) so nephrectomies were performed. Reduction pyeloplasty with nephropexy was done in 21 patients (60%) with 81% success and 23.1% complication rates. Conclusion:GH requires early diagnosis and management to prevent higher nephrectomy rate along with poor success rate of conservative surgery like pyeloplasty.

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Section: Methodsmentioning

confidence: 99%

Giant hydronephrosis: still a reality!

Kaura

Kumar

Sokhal

et al. 2017

Turkish Journal of Urology

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“…We then compared the percentages of children with normal and abnormal Scr with the CKD prevalence obtained from the Pottel equation [12] by applying this equation to a very large hospital database (from General Hospital Groeninge in Kortrijk, Belgium) where only unique patient measurements for enzymatically measured Scr were used. The database has been described in an earlier reported work [19], but we briefly describe it here. Consequently most Scr concentrations were expected to be within the so-called normal range.…”

Section: Methodsmentioning

confidence: 99%

“…When only the first measurement of each subject was considered, a total of 10,400 subjects were retained. These include the 8,505 subjects with unique Scr values that were used to calculate the median (or Q-value) and 2.5th and 97.5th percentile [19].…”

Section: Methodsmentioning

confidence: 99%

Abnormal glomerular filtration rate in children, adolescents and young adults starts below 75 mL/min/1.73 m2

2014

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“…This study was approved by the institutional review boards at each institution with the use of a waiver of informed consent for retrospective, deidentified data collection and analysis. Subjects were included if they: (1) were 3 months to 21 years of age; (2) received vancomycin for 48 hours; and (3) had normal baseline serum creatinine (SCr) as defined by age at the start of vancomycin therapy (see Supplementary Table 1) [19,20]. Subjects were excluded if they received dialysis or certain concomitant medications that are associated with nephrotoxicity, including amphotericin B, methotrexate, ifosfamide, cyclosporine, and tacrolimus.…”

Section: Methodsmentioning

confidence: 99%

Pharmacodynamic Characteristics of Nephrotoxicity Associated With Vancomycin Use in Children

Lê

Capparelli

et al. 2014

Journal of the Pediatric Infectious Diseases Society

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Background. Limited studies incorporating population-based pharmacokinetic modeling have been conducted to determine pharmacodynamic indices associated with nephrotoxicity during vancomycin exposure in children. Methods. A retrospective cohort analysis was conducted from September 2003 to December 2011 at 2 hospitals. Nephrotoxicity was defined as an increase in serum creatinine concentration (SCr) by 0.5 mg/dL, or 50% increase in baseline SCr, either persisting for 2 consecutive days. A 1-compartment model with firstorder kinetics was used in NONMEM 7.2 to estimate trough concentrations (C min ) and area under the curve over 24 hours (AUC). Univariate, classification and regression tree (CART), and multivariate analyses were conducted to identify factors contributing to nephrotoxicity. [IQR,; P < .001) were significantly higher in the nephrotoxic group compared with the non-nephrotoxic group. Using CART, we discovered that subjects with doses 60 mg/kg per day and AUC >1063 mg-h/L had a significantly higher occurrence of nephrotoxicity (P = .005). Adjusting for intensive care unit stay and concomitant nephrotoxic drugs, steady-state vancomycin C min 15 mcg/mL (adjusted odds ratio [aOR], 2.5; 95% confidence interval [CI], 1.1-5.8; P = .028) and AUC 800 mg-h/L (aOR, 3.7; 95% CI, 1.2-11.0; P = .018) were associated with increased risk of nephrotoxicity. Conclusions. Our study describes the pediatric exposure-nephrotoxicity relationships for vancomycin. Vancomycin C min 15 mcg/mL and AUC 800 mg-h/L in children are independently associated with a > 2.5-fold increased risk of nephrotoxicity and may provide justification for use of alternative antibiotics in selected situations.

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Establishing age/sex related serum creatinine reference intervals from hospital laboratory data based on different statistical methods

Cited by 159 publications

References 21 publications

Giant hydronephrosis: still a reality!

Giant hydronephrosis: still a reality!

Abnormal glomerular filtration rate in children, adolescents and young adults starts below 75 mL/min/1.73 m2

Pharmacodynamic Characteristics of Nephrotoxicity Associated With Vancomycin Use in Children

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