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Cited by 128 publications
(108 citation statements)
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“…In addition, there were some discordant pre-analytical conditions. Most studies were performed in premenopausal women but the age ranges were not identical, and contrary to Glover et al [18], we have found that women from 35 to 40 have as for CTX-I, and probably for other BTMs, may be different when assessing a broad age range in the premenopausal population. Our reference intervals, established in a narrow age range (35-45 years), may be particularly useful in the assessment of response to antiresorptive therapy in postmenopausal osteoporosis [26].…”
Section: Discussioncontrasting
confidence: 99%
See 1 more Smart Citation
“…In addition, there were some discordant pre-analytical conditions. Most studies were performed in premenopausal women but the age ranges were not identical, and contrary to Glover et al [18], we have found that women from 35 to 40 have as for CTX-I, and probably for other BTMs, may be different when assessing a broad age range in the premenopausal population. Our reference intervals, established in a narrow age range (35-45 years), may be particularly useful in the assessment of response to antiresorptive therapy in postmenopausal osteoporosis [26].…”
Section: Discussioncontrasting
confidence: 99%
“…Therefore, and taking into consideration the importance of the pre-analytical variability when establishing the reference intervals, we designed this study involving a large cohort of healthy women born in Spain, with an age range of between 35 and 45. This age range was taken because BTM levels were considered to be stable by Glover et al in their study assessing the reference interval in premenopausal British women [18]. In addition, other sources of variability were minimized, since the circadian rhythm and the influence of feeding are well known contributing factors in the pre-analytical variability of BTMs [1].…”
Section: Introductionmentioning
confidence: 99%
“…Throughout the study, the mean level of each turnover marker was in the lower part of the normal range for premenopausal women. (7) Similarly, BMD was significantly higher in the zoledronate group at all sites assessed after 3 years, and the between-group differences at each site were similar at each assessment between years 1 and 3. The effects on BMD and bone turnover are similar in magnitude to those induced by risedronate, (8) alendronate, (9) and annual administration of intravenous zoledronate (1,2) in studies that demonstrated prevention of osteoporotic fractures with these agents.…”
Section: Discussionmentioning
confidence: 65%
“…Each of the bone turnover markers was significantly lower in the zoledronate group than in the placebo group during the study, and values in the zoledronate group were in the lower part of the normal range for premenopausal women (7) (Fig. 2).…”
Section: Bone Turnover Markersmentioning
confidence: 92%
“…(16) A premenopausal reference interval was used in this study to provide a point of reference, as has been proposed by others. (12,(17)(18)(19) There appears to be a paradox: The BTMs in the placebo group are mostly within the premenopausal reference interval (only 10% are above this), and yet these patients experience fracture and bone loss. This same paradox was observed in the Health Outcomes and Reduced Incidence with Zoledronic Acid Once Yearly (HORIZON) study of zoledronic acid.…”
Section: Discussionmentioning
confidence: 99%