ESP‐102, a Combined Herbal Extract of Angelica gigas, Saururus chinensis, and Schisandra chinensis, Changes Synaptic Plasticity and Attenuates Scopolamine‐Induced Memory Impairment in Rat Hippocampus Tissue

Kim, Hyun-Bum; Hwang, Eun-Sang; Choi, Ga‐Young; Lee, Seok; Park, Tae-Suk; Lee, Cheol-Won; Lee, Eun-Suk; Kim, Young-Choong; Kim, Sang Seong; Lee, Sung-Ok; Park, Ji-Ho

doi:10.1155/2016/8793095

Cited by 6 publications

(3 citation statements)

References 19 publications

(30 reference statements)

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“…Kim et al . found that ESP-102 treatment significantly increases LTP induction in the hippocampal slice, and can also recover the scopolamine-suppressed BDNF and GluR2 protein levels, suggesting that ESP-102 is a novel herbal ingredient with memory-enhancing as well as neuroprotective effects [ 100 ]. As stated above, Rg1, which prevents glutamate-induced neuronal death, might not act by antagonizing NMDA receptors [ 81 ].…”

Section: Regulation Of Glutamate-mediated Signaling By the Natural Comentioning

confidence: 99%

Chinese Herbal Medicine Interventions in Neurological Disorder Therapeutics by Regulating Glutamate Signaling

Liu

Wang

Kan

et al. 2020

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Glutamate is the major excitatory neurotransmitter in the central nervous system, and its signaling is critical for excitatory synaptic transmission. The well-established glutamate system involves glutamate synthesis, presynaptic glutamate release, glutamate actions on the ionotropic glutamate receptors (NMDA, AMPA, and kainate receptors) and metabotropic glutamate receptors, and glutamate uptake by glutamate transporters. When the glutamate system becomes dysfunctional, it contributes to the pathogenesis of neurodegenerative and neuropsychiatric diseases such as Alzheimer's disease, Parkinson's disease, depression, epilepsy, and ischemic stroke. In this review, based on regulating glutamate signaling, we summarize the effects and underlying mechanisms of natural constituents from Chinese herbal medicines on neurological disorders. Natural constituents from Chinese herbal medicine can prevent the glutamate-mediated excitotoxicity via suppressing presynaptic glutamate release, decreasing ionotropic and metabotropic glutamate receptors expression in the excitatory synapse, and promoting astroglial glutamate transporter expression to increase glutamate clearance from the synaptic cleft. However, some natural constituents from Chinese herbal medicine have the ability to restore the collapse of excitatory synapses by promoting presynaptic glutamate release and increasing ionotropic and metabotropic glutamate receptors expression. These regulatory processes involve various signaling pathways, which lead to different mechanistic routes of protection against neurological disorders. Hence, our review addresses the underlying mechanisms of natural constituents from Chinese herbal medicines that regulate glutamate systems and serve as promising agents for the treatment of the above-mentioned neurological disorders.

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Section: Regulation Of Glutamate-mediated Signaling By the Natural Comentioning

confidence: 99%

Chinese Herbal Medicine Interventions in Neurological Disorder Therapeutics by Regulating Glutamate Signaling

Liu

Wang

Kan

et al. 2020

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“…Furthermore, ESP-102 controlled the loss of mitochondrial membrane potential in glutamate-induced rat cortical cells. Recently, the neuroprotective effect of ESP-102 against scopolamine-induced toxicity in rat hippocampal slice was studied by Kim et al [ 34 ]. The results showed that ESP-102 competitively antagonized the preventative long-term potentiation effect in the scopolamine-induced hippocampal slice.…”

Section: Neuroprotective Properties Of a Gigas mentioning

confidence: 99%

Neuroprotective and Cognitive Enhancement Potentials of Angelica gigas Nakai Root: A Review

Sowndhararajan

2017

Sci. Pharm.

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Angelica gigas Nakai is an important medicinal plant with health promoting properties that is used to treat many disorders. In traditional herbal medicine, the root of this plant is used to promote blood flow, to treat anemia, and is used as sedative or tonic agent. The root contains various bioactive metabolites; in particular, decursin and decursinol (pyranocoumarin type components) have been reported to possess various pharmacological properties. Recently, several in vitro and in vivo studies have reported that the crude extracts and isolated components from the root of A. gigas exhibited neuroprotective and cognitive enhancement effects. Neuronal damage or death is the most important factor for many neurodegenerative diseases. In addition, recent studies have clearly demonstrated the possible mechanisms behind the neuroprotective action of extracts/compounds from the root of A. gigas. In the present review, we summarized the neuroprotective and cognitive enhancement effects of extracts and individual compounds from A. gigas root.

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“…Sauchinone, a biologically active lignan isolated from the aerial parts of S. chinensis , also shows anti-oxidative, anti-inflammatory, hepatoprotective, anti-cardiovascular, anti-obesity, and anti-hepatic steatosis activities [ 17 , 18 , 19 , 20 , 21 , 22 ]. Recently, the approval of ESP-102 as a functional food containing sauchinone from S. chinensis (Daewoong Bio, South Korea; [ 17 ]) shows that S. chinensis can be developed as a source of functional food or herbal medicine in combination therapies [ 18 , 19 , 20 , 21 , 22 ]. As a major component of S. chinensis , sauchinone is extensively metabolized via CYPs and is highly distributed in the liver [ 23 ], suggesting that sauchinone–drug interaction may occur via CYP inhibition.…”

Section: Introductionmentioning

confidence: 99%

Enzyme Kinetics and Molecular Docking Studies on Cytochrome 2B6, 2C19, 2E1, and 3A4 Activities by Sauchinone

et al. 2018

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Sauchinone, an active lignan isolated from the aerial parts of Saururus chinensis (Saururaceae), exhibits anti-inflammatory, anti-obesity, anti-hyperglycemic, and anti-hepatic steatosis effects. As herb–drug interaction (HDI) through cytochrome P450s (CYPs)-mediated metabolism limits clinical application of herbs and drugs in combination, this study sought to explore the enzyme kinetics of sauchinone towards CYP inhibition in in vitro human liver microsomes (HLMs) and in vivo mice studies and computational molecular docking analysis. In in vitro HLMs, sauchinone reversibly inhibited CYP2B6, 2C19, 2E1, and 3A4 activities in non-competitive modes, showing inhibition constant (Ki) values of 14.3, 16.8, 41.7, and 6.84 μM, respectively. Also, sauchinone time-dependently inhibited CYP2B6, 2E1 and 3A4 activities in vitro HLMs. Molecular docking study showed that sauchinone could be bound to a few key amino acid residues in the active site of CYP2B6, 2C19, 2E1, and 3A4. When sibutramine, clopidogrel, or chlorzoxazone was co-administered with sauchinone to mice, the systemic exposure of each drug was increased compared to that without sauchinone, because sauchinone reduced the metabolic clearance of each drug. In conclusion, when sauchinone was co-treated with drugs metabolized via CYP2B6, 2C19, 2E1, or 3A4, sauchinone–drug interactions occurred because sauchinone inhibited the CYP-mediated metabolic activities.

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ESP‐102, a Combined Herbal Extract of Angelica gigas, Saururus chinensis, and Schisandra chinensis, Changes Synaptic Plasticity and Attenuates Scopolamine‐Induced Memory Impairment in Rat Hippocampus Tissue

Cited by 6 publications

References 19 publications

Chinese Herbal Medicine Interventions in Neurological Disorder Therapeutics by Regulating Glutamate Signaling

Chinese Herbal Medicine Interventions in Neurological Disorder Therapeutics by Regulating Glutamate Signaling

Neuroprotective and Cognitive Enhancement Potentials of Angelica gigas Nakai Root: A Review

Enzyme Kinetics and Molecular Docking Studies on Cytochrome 2B6, 2C19, 2E1, and 3A4 Activities by Sauchinone

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