Escherichia coli Septicemia in Nonperforated Appendicitis

Blood culture positivity in patients with acute appendicitis: A propensity score–matched prospective cohort study

“…To our knowledge, there is only one previous study assessing blood culture positivity in adult patients with acute appendicitis. 17 The bacteremia prevalence rate in this study 17 and the earlier studies mainly in pediatric patient cohorts 22–24 are corroborated by the outcomes of this study. One retrospective study on children reported bacteremia of 17% and 8% in perforated and non-perforated acute appendicitis, 24 when in our study bacteremia was diagnosed in 15% and 5%, respectively.…”

“…17 The bacteremia prevalence rate in this study 17 and the earlier studies mainly in pediatric patient cohorts 22–24 are corroborated by the outcomes of this study. One retrospective study on children reported bacteremia of 17% and 8% in perforated and non-perforated acute appendicitis, 24 when in our study bacteremia was diagnosed in 15% and 5%, respectively. There was huge variety in the overall prevalence in the earlier studies ranging from 0.35% to 17%, 22–24 and as all these other studies were performed in pediatric populations, they are not directly comparable to our study with adult patients.…”

“…One retrospective study on children reported bacteremia of 17% and 8% in perforated and non-perforated acute appendicitis, 24 when in our study bacteremia was diagnosed in 15% and 5%, respectively. There was huge variety in the overall prevalence in the earlier studies ranging from 0.35% to 17%, 22–24 and as all these other studies were performed in pediatric populations, they are not directly comparable to our study with adult patients. Both epidemiological and clinical studies have shown that non-operative treatment for uncomplicated acute appendicitis is efficient, safe, and cost-effective.…”

“…One retrospective study on children reported bacteremia of 17% and 8% in perforated and non-perforated acute appendicitis, 24 when in our study bacteremia was diagnosed in 15% and 5%, respectively. There was huge variety in the overall prevalence in the earlier studies ranging from 0.35% to 17%, [22][23][24] and as all these other studies were performed in pediatric populations, they are not 1 All 29 patients were treated with appendectomy, and 2 patients received only preoperative dose of antibiotics. Appendicitis was considered as complicated when presenting with an appendicolith, perforation, periappendicular abscess, tumor, or clear intraoperative finding of gangrene supported by histopathology.…”

The Sepsis Bundle Effect: An Evaluation of Culture Results and Utilization in Pediatric Appendicitis

“…True bacteremia is rare in children with acute appendicitis, with occurrence ranging in the literature from <.5% to 6%, 14,15 and E. coli , B. fragilis , and K. pneumoniae most frequently cultured. Due to the rarity of associated bacteremia, literature is limited and the clinical significance as well as treatment implications of a true positive culture when appendectomy is performed remain unknown.…”