Escherichia Coli Keratitis Treated with Ultraviolet A/Riboflavin Corneal Cross-Linking: A Case Report

Abstract

Purpose To describe a case of keratitis caused by the Gram-negative Escherichia coli, treated with UVA-riboflavin cross linking. Methods Case report. Results A 78-year-old woman with diabetes presented with a 1-week history of pain, photophobia, foreign body sensation, and lacrimation in the right eye. The patient underwent topical and systemic antimicrobial therapy, without improvement. The authors treated the patient with riboflavin and corneal UVA crosslinking, with the aim to promote healing of the ulceration. One day after the procedure, the corneal ulceration was covered by cicatricial tissue, and the patient reported a significant improvement in symptoms. One month after the treatment, corneal edema was almost completely resolved, corneal ulceration was healed, and the painful symptoms of the patient had disappeared. Conclusions UVA-riboflavin crosslinking can be useful for the treatment of corneal ulceration unresponsive to medical treatment.

Antimicrobial Activity of Simulated Solar Disinfection against Bacterial, Fungal, and Protozoan Pathogens and Its Enhancement by Riboflavin

“…The combination of UVA radiation and riboflavin (vitamin B 2 ) has recently been reported to have therapeutic application in the treatment of bacterial and fungal ocular pathogens (13,17) and has also been proposed as a method for decontaminating donor blood products prior to transfusion (1). In the present study, we report that the addition of riboflavin significantly enhances the disinfectant efficacy of simulated SODIS against bacterial, fungal, and protozoan pathogens.…”

Corneal Collagen Cross-linking for Treatment of Bacterial and Herpetic Keratitis

“…Several cases of bacterial keratitis such as Pseudomonas keratitis [26], Escherichia coli keratitis [27] and polymicrobial keratitis [28] have also been reported after UV-A/ riboflavin corneal cross-linking. Herpetic keratitis with iritis after corneal cross-linking has also been reported [29].…”

Modern treatments for purulent corneal ulcers

“…[19] и группы A. Schrier и соавт. [20] стали появляться работы о применении метода КРЛ в лечении тяжелых бакте-риальных кератитов, включая бактериальные кера-титы с изъязвлением, грибковые и акантамебные кератиты [25][26][27][28][29][30].…”