Castor plant (Ricinus communis L.) is a non-edible oilseed crop with unique oil features for the chemistry industry. The crop was very important in the mid and late nineteenth century and also during WWI. After that the crop lost its importance in developed countries (Godfrey, 1923), but in India and Brazil it has remained as the most important non-edible oilseed crop of the arid and semi-arid regions (Dange et al., 2005; Santos et al., 2007). Nowadays, due the constant pressure for renewable fuels, castor has been investigated as a potential source of biofuel, mainly in Brazil due to governmental stimulus, and this has raised the crop importance once again. Regardless of the lack of a well established crop system, castor hosts several pests and diseases which cause heavy losses in the crop yield. One of the most destructive diseases of castor is gray mold, caused by the fungus Botryotinia ricini (Godfrey) Whetzel. Actually, it is the anamorphic phase of B. ricini, known as Amphobotrys ricini (N.F. Buchw.) Hennebert, that is responsible for disease epidemics and heavy yield losses frequently observed in castor crops. The first epidemic outbreak caused by this fungus was reported by H.E. Stevens of the Florida Experiment Station, Gainesville, Florida (Godfrey, 1919, 1923). At that time, a meticulous study was conducted and much of our knowledge regarding the disease and its causal agent was published in the classic work of Godfrey (1923). Subsequently, only sporadic works were conducted by other scientists around the world, consequently few advances have been made on management of gray mold. Breeding programs have failed in developing varieties with satisfactory resistance levels (Kolte, 1995), and chemical control is still ineffective and economically prohibitive, mainly due to the lack of basal information about the causal organism and its biology. In this chapter, the major aspects of castor gray mold will be reviewed. 2. Gray mold of castor 2.1 Historic and economic importance Castor gray mold was first reported in the USA in 1918, following pioneering investigations by H.E. Stevens and F. W. Patterson, who promptly suggested that the causal organism of castor gray mold was an unknown Botrytis species (Godfrey, 1919, 1923). This fungus had caused serious losses of castor crop in the summer of 1918 mainly in Florida and others southern States, where it was responsible for losses up to 100% of castor yield (Godfrey, www.intechopen.com Plant Pathology 220 1923). Later, the disease was reported in almost all countries where castor has been cultivated (Kolte, 1995), having nowadays a worldwide distribution.