Erythromycin in the Treatment of Early Syphilis

Treatment of Early Venereal Syphilis with Antibiotics

“…Although a dose of 30 g. given over a period of at least 8 days has been suggested (Montgomery and Knox, 1959a), cures can be obtained with less (e.g. 10 g. over 10 days) but higher failure rates are obtained with the same amount over a shorter time (Montgomery and Knox, 1959b;Montero, 1956 (Hookings and Graves, 1956).…”

Treatment of Early Venereal Syphilis with Antibiotics

“…Penicillin is undoubtedly superior, but chlortetracycline, chloramphenicol, oxytetracycline, and also tetracycline are effective, as are carbomycin (Magnamycin) and erythromycin (Montgomery and Knox, 1959a;Buckinger, Hookings, and Garson, 1955). T. pallidum is reported to be more sensitive to erythromycin and carbomycin than to other antibiotics except penicillin (Thomas, 1959), but because the tetracyclines have been available longer, there is a greater experience with their use, and also to a lesser extent with that of chloramphenicol (King, 1959;Olansky and Garson, 1958).…”

“…Although a dose of 30 g. given over a period of at least 8 days has been suggested (Montgomery and Knox, 1959a), cures can be obtained with less (e.g. 10 g. over 10 days) but higher failure rates are obtained with the same amount over a shorter time (Montgomery and Knox, 1959b;Montero, 1956).…”

“…Although a dose of 30 g. given over a period of at least 8 days has been suggested (Montgomery and Knox, 1959a), cures can be obtained with less (e.g. 10 g. over 10 days) but higher failure rates are obtained with the same amount over a shorter time (Montgomery and Knox, 1959b;Montero, 1956). The schedule recommended by the United States Public Health Service (U.S.P.H.S., 1960) is 20 to 30 g. over 10 to 15 days, but a close follow-up is urged as an adequate evaluation of these alternative antibiotics has yet to be made.…”

Erythromycin in early syphilis.

“…Alexander and Schoch (1954) treated four cases of early syphilis with erythromycin and observed the rapid disappearance of Treponema pallidum from the lesions, noting that the lesions healed as promptly as with other drugs. Montero (1956) treated 27 cases of early syphilis with erythromycin (9-12 g.) with satisfactory results, and Montgomery and Knox (1959) obtained encouraging results in forty cases using a similar dosage. Gertler (1961) treated twelve patients with early syphilis using 1-1-6 g. of erythromycin daily for 15-20 days (follow-up period 7 months) and concluded that erythromycin had a place in the treatment of those allergic to penicillin.…”