Erythrofordins D and E, two new cassaine-type diterpenes from Erythrophleum suaveolens

Abstract

Two new cassaine-type diterpenoids, namely erythrofordins D (1) and E (2), sourced from a Cameroon collection of Erythrophleum suaveolens were isolated and assessed for anti-tumor

National Cancer Institute (NCI) Program for Natural Product Discovery: Exploring NCI-60 Screening Data of Natural Product Samples with Artificial Neural Networks

“…The analysis can be further annotated with the integration of knowledge of chemical structure known to be responsible for a particular NCI-60 cell response. The utility of this approach is shown by the clustering of plant extracts which we have determined in various screening campaigns , possess a biological signature in the NCI-60 panel that is diagnostic of cardiac glycosides (Figure B). Also indicated on the SOM are the nodes where three prototypal cardiac glycoside NCI-60 profiles, namely digitoxin (NSC 7529), neriifolin (NSC 123976), and β-k-strophanthin (NSC 44320), are found, with the three compounds positioned separately on the SOM because of differences in potency.…”

“…NMR spectra were recorded at 25 °C on a 400 MHz Agilent Inova spectrometer equipped with a 5 mm OneNMR probe. The 1 H and 13 C NMR chemical shifts were referenced to the solvent peaks for CDCl 3 at δ H 7.26 and δ C 77.0. NMR FID processing and data interpretation was done using MestReNova software, version 14.0.…”