Erythroderma. Who, where, when, why, and how ..

Histoplasmosis presenting as erythroderma in a patient with the acquired immunodeficiency syndrome

“…Malignancy, especially lymphoma, should also be considered in the search for the cause of erythroderma in patients with AIDS. Approximately 10% of HIV‐positive patients develop lymphoma, usually of the B‐cell type 39,40 . In our patient, there was no histologic evidence of lymphoma in the skin or bone marrow, and no visceral malignancy was identified.…”

Erythroderma: A Clinical Study of 127 Cases and Review of the Literature

“…In the study of Botella-Estrada et al [8], the best clinicohistological correlation was found in cutaneous-T-cell-lymphoma-related El Euch et al erythroderma. Biopsy specimens taken from sites of predilection of papulosquamous diseases that persist for more than 3-6 weeks after the erythema has resolved are more likely to have diagnostic features [15]. Only 1 patient in our series showed a malignant node infiltration revealing a CD30 T cell lymphoma not evident in previous skin biopsies.…”

Heteroduplex analysis of T‐cell receptor γ gene rearrangement as an adjuvant diagnostic tool in skin biopsies for erythroderma

“…The difficulty of identifying the underlying etiology of erythroderma through histopathology alone is well established, and several articles address this issue 1, 2, 4, 5 . Walsh et al examined 56 skin biopsies from 40 erythrodermic patients and found that the mean accuracy of the histopathological diagnoses was 53%, with a range of 48–66%; accuracy varied by pathologist as well as by diagnosis, e.g., the greatest degree of accuracy was observed in cases of spongiotic dermatitis and the least in those of PRP 4 .…”